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Protein (NX_Q9UBB5)
Protein
Gene SymbolMBD2 to neXtProt (NX_Q9UBB5)
DescriptionMethyl-CpG-binding domain protein 2
Chromosome18
Location18q21.2 (51679079 ~ 51751158) to Ensembl
Sequene Features : Isoforms 2, Variants 28, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of transcription, DNA-templated
.negative regulation of gene expression, epigenetic
.cellular protein complex assembly
  + 8 more...
.C2H2 zinc finger domain binding
.siRNA binding
.protein domain specific binding
  + 4 more...
.protein complex
.cytoplasm
.nucleoplasm
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 28 3
2014-09-19protein level
2 20 3
2014-05-27protein level
2 20 3
2014-02-25protein level
2 20 3
2013-12-09protein level
2 15 3
2013-11-01protein level
2 13 3
2013-09-12protein level
2 13 3
2013-08-17protein level
2 13 3
2013-07-15protein level
2 10 3
2013-06-11protein level
2 10 3
2013-02-12protein level
2 5 3
2012-12-20protein level
2 5 3
2012-10-30protein level
2 7 3
2012-10-07protein level
2 7 2
2012-08-24protein level
2 5 2
2012-07-28protein level
2 5 2
2012-06-08protein level
2 5 2
2012-05-07protein level
3 5 2
2012-04-10protein level
3 5 2
2012-01-13protein level
3 6 2
2011-12-20protein level
3 6 2
2011-11-11protein level
3 6 2
2011-08-23protein level
3 6 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9UBB5-1
8 7 0 43227.7764
NX_Q9UBB5-3
3 7 0 31724.8685
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
ascites50
bladder133
blood73
bone55
bone marrow20
brain11
connective tissue201
ear124
embryonic tissue9
esophagus49
eye43
heart55
intestine51
kidney14
larynx170
liver38
lung20
lymph node122
mammary gland52
mouth45
muscle28
nerve64
ovary78
pancreas46
parathyroid48
pharynx98
pituitary gland60
placenta67
prostate84
skin56
stomach41
testis13
thyroid42
uterus103
vascular58
Health State
TissuesTPM*
normal39
adrenal tumor79
bladder carcinoma113
breast (mammary gland) tumor32
chondrosarcoma84
colorectal tumor62
esophageal tumor57
gastrointestinal tumor59
germ cell tumor26
glioma46
head and neck tumor44
kidney tumor29
leukemia63
liver tumor20
lung tumor19
lymphoma96
non-neoplasia62
ovarian tumor91
pancreatic tumor28
primitive neuroectodermal tumor of the CNS7
prostate cancer144
retinoblastoma21
skin tumor39
soft tissue/muscle tissue tumor239
uterine tumor99
Developmental Stage
TissuesTPM*
adult78
embryoid body28
neonate32
fetus37
infant42
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue51.1
adrenal gland25.9
appendix51
bone marrow30.5
cerebral cortex11.9
colon41.2
duodenum33.1
esophagus43.6
gallbladder23.2
heart muscle17.8
kidney29.4
liver20.6
lung33.1
lymph node63.7
ovary22.1
pancreas14.4
placenta44.3
prostate24.7
salivary gland30.6
skin43.2
small intestine32
spleen39.6
stomach28.6
testis30.9
thyroid gland48.5
urinary bladder34.5
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603547, gene) Methyl-cpg-binding domain protein 2; MBD2OMIM


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