Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_Q9UBB9)
Protein (NX_Q9UBB9)
Protein
Gene SymbolTFIP11 to neXtProt (NX_Q9UBB9)
DescriptionTuftelin-interacting protein 11
Chromosome22
Location22q12.1 (26887191 ~ 26908471) to Ensembl
Sequene Features : Isoforms 2, Variants 109, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.biomineral tissue development
.RNA processing
.regulation of transcription, DNA-templated
  + 2 more...
.DNA binding .catalytic step 2 spliceosome
.U2-type post-mRNA release spliceosomal complex
.nuclear speck
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 109 7
2014-09-19protein level
2 85 7
2014-05-27protein level
2 85 7
2014-02-25protein level
2 83 7
2013-12-09protein level
2 63 7
2013-11-01protein level
2 59 5
2013-09-12protein level
2 59 5
2013-08-17protein level
2 59 5
2013-07-15protein level
2 40 5
2013-06-11protein level
2 40 5
2013-02-12protein level
2 22 7
2012-12-20protein level
2 19 7
2012-10-30protein level
2 28 7
2012-10-07protein level
2 28 6
2012-08-24protein level
2 22 6
2012-07-28protein level
2 22 6
2012-06-08protein level
2 22 6
2012-05-07protein level
2 22 6
2012-04-10protein level
2 22 6
2012-01-13protein level
2 9 6
2011-12-20protein level
2 9 6
2011-11-11protein level
2 9 5
2011-08-23protein level
2 9 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9UBB9-1
32 10 0 96758.1653
NX_Q9UBB9-2
1 10 0 22416.0673
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1105213,EBI-2559305 VPS37C  
  .intracellular transport of virus
.membrane organization
.viral protein processing
  + 5 more...
.calcium-dependent protein binding .extracellular exosome
.late endosome membrane
.endosome membrane
.ESCRT I complex
2 EBI-1105213,EBI-8466445 CCDC151  
  .regulation of cilium assembly
.cell projection organization
.cilium movement
.N/A .ciliary basal body
.axoneme
.cilium
.centriole
3 EBI-1105213,EBI-715849 NDC80  
  .attachment of mitotic spindle microtubules to kinetochore
.cell division
.attachment of spindle microtubules to kinetochore
  + 7 more...
.identical protein binding
.structural constituent of cytoskeleton
.Ndc80 complex
.membrane
.cytosol
  + 5 more...
4 EBI-1105213,EBI-1210440 ZSCAN12  
  .transcription, DNA-templated .metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
5 EBI-1105213,EBI-536879 OIP5  
  .cell division
.CENP-A containing nucleosome assembly
.cell communication
  + 2 more...
.N/A .Cajal body
.chromocenter
.cytoplasm
  + 4 more...
6 EBI-1105213,EBI-1046642 STRN  
  .tight junction assembly
.dendrite development
.Wnt signaling pathway
  + 2 more...
.armadillo repeat domain binding
.protein phosphatase 2A binding
.protein complex binding
  + 2 more...
.postsynaptic membrane
.dendritic spine
.neuronal cell body
  + 4 more...
7 EBI-1105213,EBI-8473670 LCA5L  
  .N/A .N/A .N/A
8 EBI-1105213,EBI-702198 KRT6A  
  .activation of mitophagy in response to mitochondrial depolarization
.wound healing
.cell differentiation
  + 3 more...
.structural constituent of cytoskeleton .extracellular exosome
.keratin filament
.membrane
.nucleus
9 EBI-1105213,EBI-740907 KRT6B  
  .ectoderm development .structural constituent of cytoskeleton .extracellular exosome
.keratin filament
10 EBI-1105213,EBI-297852 KRT8  
  .hepatocyte apoptotic process
.extrinsic apoptotic signaling pathway
.cell differentiation involved in embryonic placenta development
  + 5 more...
.scaffold protein binding
.structural molecule activity
.extracellular exosome
.intermediate filament cytoskeleton
.keratin filament
  + 10 more...
11 EBI-1105213,EBI-1053725 COX5B  
  .hydrogen ion transmembrane transport
.small molecule metabolic process
.cellular metabolic process
  + 4 more...
.metal ion binding
.cytochrome-c oxidase activity
.extracellular exosome
.mitochondrial inner membrane
.mitochondrion
12 EBI-1105213,EBI-726527 TNNT1  
  .negative regulation of muscle contraction
.slow-twitch skeletal muscle fiber contraction
.muscle filament sliding
.skeletal muscle contraction
.tropomyosin binding .troponin complex
.cytosol
13 EBI-1105213,EBI-372475 SNRPB  
  .activation of mitophagy in response to mitochondrial depolarization
.ncRNA metabolic process
.mRNA 3'-end processing
  + 9 more...
.histone pre-mRNA DCP binding
.poly(A) RNA binding
.histone pre-mRNA 3'end processing complex
.catalytic step 2 spliceosome
.U2-type prespliceosome
  + 14 more...
14 EBI-1105213,EBI-8639312 LMO1  
  .positive regulation of transcription from RNA polymerase II promoter
.negative regulation of transcription from RNA polymerase II promoter
.zinc ion binding .nucleus
15 EBI-1105213,EBI-743700 S100P  
  .endothelial cell migration
.response to organic substance
.calcium-dependent protein binding
.calcium ion binding
.magnesium ion binding
.extracellular exosome
.microvillus membrane
.cytoplasm
.nucleus
16 EBI-1105213,EBI-375013 CCND3  
  .cell division
.positive regulation of cyclin-dependent protein serine/threonine kinase activity
.T cell proliferation
  + 3 more...
.protein kinase binding
.cyclin-dependent protein serine/threonine kinase activity
.membrane
.cytoplasm
.nucleus
.cyclin-dependent protein kinase holoenzyme complex
17 EBI-1105213,EBI-742094 KRT20  
  .regulation of protein secretion
.intermediate filament organization
.cellular response to stress
.apoptotic process
.structural constituent of cytoskeleton .intermediate filament
.cytoplasm
18 EBI-1105213,EBI-359793 TXLNA  
  .activation of mitophagy in response to mitochondrial depolarization
.B cell activation
.cell proliferation
.exocytosis
.high molecular weight B cell growth factor receptor binding
.cytokine activity
.membrane
.cytoplasm
.extracellular region
19 EBI-1105213,EBI-355815 ATP5O  
  .small molecule metabolic process
.cellular metabolic process
.mitochondrial ATP synthesis coupled proton transport
  + 3 more...
.proton-transporting ATP synthase activity, rotational mechanism
.transmembrane transporter activity
.drug binding
.transporter activity
.extracellular exosome
.plasma membrane
.mitochondrial proton-transporting ATP synthase complex
  + 3 more...
20 EBI-1105213,EBI-2564105 KRT6C  
  .intermediate filament cytoskeleton organization .structural molecule activity .extracellular exosome
.keratin filament
.intermediate filament
21 EBI-1105213,EBI-3905829 CCNG1  
  .cell division
.negative regulation of apoptotic process
.cell growth
  + 6 more...
.N/A .perinuclear region of cytoplasm
.neuronal cell body
.dendrite
.nucleus
22 EBI-1105213,EBI-744104 GEM  
  .metaphase plate congression
.chromosome organization
.metabolic process
  + 5 more...
.GDP binding
.GTP binding
.GTPase activity
.magnesium ion binding
.mitotic spindle
.spindle midzone
.midbody
  + 2 more...
23 EBI-1105213,EBI-2798728 LMO4  
  .regulation of cell activation
.thymus development
.positive regulation of transcription from RNA polymerase II promoter
  + 8 more...
.zinc ion binding
.transcription factor binding
.sequence-specific DNA binding transcription factor activity
.enhancer sequence-specific DNA binding
.transcription factor complex
24 EBI-1105213,EBI-745226 AIMP2  
  .Type II pneumocyte differentiation
.positive regulation of protein ubiquitination
.gene expression
  + 3 more...
.N/A .membrane
.cytosol
.nucleus
25 EBI-1105213,EBI-713355 GPS2  
  .negative regulation of JNK cascade
.negative regulation of GTPase activity
.JNK cascade
  + 4 more...
.GTPase inhibitor activity
.transcription corepressor activity
.transcriptional repressor complex
.nucleoplasm
26 EBI-1105213,EBI-632715 SNW1  
  .cellular response to retinoic acid
.positive regulation of vitamin D receptor signaling pathway
.regulation of vitamin D receptor signaling pathway
  + 19 more...
.SMAD binding
.poly(A) RNA binding
.retinoic acid receptor binding
  + 5 more...
.catalytic step 2 spliceosome
.nuclear matrix
.spliceosomal complex
  + 3 more...
27 EBI-1105213,EBI-719941 FAM161A  
  .response to stimulus
.cilium assembly
.visual perception
.N/A .ciliary basal body
.photoreceptor connecting cilium
.centrosome
.cytoplasm
28 EBI-1105213,EBI-740767 ZC2HC1C  
  .N/A .metal ion binding .N/A
29 EBI-1105213,EBI-739879 ALS2CR11  
  .N/A .N/A .N/A
30 EBI-1105213,EBI-2557469 PPP1R18  
  .N/A .N/A .cytoskeleton
.cytoplasm
31 EBI-1105213,EBI-10252703 MTFR2  
  .aerobic respiration
.mitochondrion organization
.mitochondrial fission
.N/A .mitochondrion
32 EBI-1105213,EBI-2836982 CCDC121  
  .N/A .N/A .N/A
33 EBI-1105213,EBI-2557212 IKBIP  
  .response to X-ray .N/A .integral component of membrane
.membrane
.endoplasmic reticulum membrane
.endoplasmic reticulum
34 EBI-1105213,EBI-2515234 CENPU  
  .chordate embryonic development
.CENP-A containing nucleosome assembly
.viral process
  + 5 more...
.N/A .cytosol
.microtubule organizing center
.nucleoplasm
  + 2 more...
35 EBI-1105213,EBI-744896 SNX20  
  .protein transport .phosphatidylinositol binding .endosome membrane
.plasma membrane
.nucleus
36 EBI-1105213,EBI-1104535 SFR1  
  .double-strand break repair via homologous recombination .N/A .Swi5-Sfr1 complex
.nucleus
37 EBI-1105213,EBI-308614 CEP57  
  .protein homooligomerization
.microtubule anchoring
.fibroblast growth factor receptor signaling pathway
  + 5 more...
.protein homodimerization activity
.fibroblast growth factor binding
.microtubule cytoskeleton
.microtubule
.cytosol
  + 5 more...
38 EBI-1105213,EBI-10247802 CCDC146  
  .N/A .N/A .centriole
39 EBI-1105213,EBI-749051 C6orf165  
  .N/A .N/A .N/A
40 EBI-1105213,EBI-744311 CCDC116  
  .N/A .N/A .centrosome
41 EBI-1105213,EBI-1104570 CEP57L1  
  .microtubule anchoring .N/A .microtubule
.microtubule organizing center
.cytoplasm
42 EBI-1105213,EBI-3439227 ZGPAT  
  .negative regulation of transcription, DNA-templated
.negative regulation of epidermal growth factor-activated receptor activity
.negative regulation of transcription from RNA polymerase II promoter
.metal ion binding
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
  + 2 more...
.nucleus
43 EBI-1105213,EBI-717429 THAP8  
  .N/A .metal ion binding
.DNA binding
.N/A
44 EBI-1105213,EBI-749727 FAM156B  
  .N/A .N/A .integral component of membrane
.nuclear envelope
45 EBI-1105213,EBI-751248 FAM13C  
  .N/A .N/A .N/A
46 EBI-1105213,EBI-745535 ADCK3  
  .phosphorylation
.ubiquinone biosynthetic process
.ADP binding
.kinase activity
.ATP binding
.integral component of membrane
.mitochondrion
47 EBI-1105213,EBI-740727 ZNF417  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
48 EBI-1105213,EBI-10175300 CCHCR1  
  .cell differentiation
.multicellular organismal development
.protein export from nucleus
.N/A .centriole
.cytoplasm
.nucleus
49 EBI-1105213,EBI-6164177 GOLGA1  
  .protein targeting to Golgi .N/A .perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.Golgi cisterna membrane
  + 2 more...
50 EBI-1105213,EBI-455078 SMARCE1  
  .negative regulation of transcription, DNA-templated
.ATP-dependent chromatin remodeling
.metabolic process
  + 4 more...
.protein N-terminus binding
.ligand-dependent nuclear receptor binding
.N-acetyltransferase activity
  + 4 more...
.nBAF complex
.npBAF complex
.protein complex
  + 6 more...
51 EBI-1105213,EBI-726510 LENG1  
  .N/A .N/A .N/A
52 EBI-1105213,EBI-746252 GCC1  
  .protein targeting to Golgi .N/A .plasma membrane
.Golgi apparatus
.cytoplasm
.Golgi membrane
53 EBI-1105213,EBI-2514791 HAUS1  
  .cell division
.centrosome organization
.spindle assembly
.mitotic nuclear division
.N/A .HAUS complex
.microtubule
.centrosome
  + 2 more...
54 EBI-1105213,EBI-748884 LIN37  
  .regulation of cell cycle
.mitotic cell cycle
.G2/M transition of mitotic cell cycle
.N/A .transcriptional repressor complex
.nucleoplasm
55 EBI-1105213,EBI-3919268 BMF  
  .positive regulation of intrinsic apoptotic signaling pathway
.negative regulation of apoptotic signaling pathway
.positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
  + 6 more...
.N/A .myosin complex
.plasma membrane
.cytosol
  + 2 more...
56 EBI-1105213,EBI-747041 CCDC42  
  .N/A .N/A .N/A
57 EBI-1105213,EBI-2682299 ZMAT2  
  .N/A .zinc ion binding
.DNA binding
.nucleus
58 EBI-1105213,EBI-9658624 RHNO1  
  .cellular response to ionizing radiation
.positive regulation of G0 to G1 transition
.cellular response to UV
  + 2 more...
.N/A .chromosome
.nucleus
59 EBI-1105213,EBI-741350 THAP7  
  .negative regulation of transcription, DNA-templated
.transcription, DNA-templated
.C2H2 zinc finger domain binding
.protein N-terminus binding
.metal ion binding
.DNA binding
.nuclear speck
.chromosome
60 EBI-1105213,EBI-10302990 PBX4  
  .positive regulation of transcription, DNA-templated
.transcription from RNA polymerase II promoter
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.nucleus
.XY body
61 EBI-1105213,EBI-751319 CARD9  
  .nucleotide-binding oligomerization domain containing signaling pathway
.defense response to virus
.defense response to Gram-positive bacterium
  + 17 more...
.CARD domain binding
.protein homodimerization activity
.plasma membrane
.cytosol
.cytoplasm
62 EBI-1105213,EBI-2813327 CCDC68  
  .N/A .N/A .N/A
63 EBI-1105213,EBI-747035 SH2D4A  
  .negative regulation of phosphatase activity .phosphatase binding .cytoplasm
64 EBI-1105213,EBI-749353 METTL17  
  .translation .methyltransferase activity
.copper ion binding
.ribosome
.mitochondrion
.nucleoplasm
.nucleus
65 EBI-1105213,EBI-747481 IMP3  
  .rRNA processing .poly(A) RNA binding
.snoRNA binding
.Mpp10 complex
.small-subunit processome
.nucleolus
.nucleus
66 EBI-1105213,EBI-8643161 C1orf109  
  .N/A .N/A .N/A
67 EBI-1105213,EBI-743598 ABI2  
  .positive regulation of Arp2/3 complex-mediated actin nucleation
.peptidyl-tyrosine phosphorylation
.Rac protein signal transduction
  + 5 more...
.proline-rich region binding
.protein complex binding
.ubiquitin protein ligase binding
  + 4 more...
.SCAR complex
.filopodium
.lamellipodium
  + 3 more...
68 EBI-1105213,EBI-713401 HMG20B  
  .positive regulation of neuron differentiation
.skeletal muscle cell differentiation
.negative regulation of protein sumoylation
  + 6 more...
.chromatin binding
.DNA binding
.chromosome
.nucleoplasm
69 EBI-1105213,EBI-2843626 ARMCX1  
  .N/A .N/A .integral component of membrane
70 EBI-1105213,EBI-743428 RCOR3  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.chromatin binding
.DNA binding
.nucleus
71 EBI-1105213,EBI-10320765 POLL  
  .somatic hypermutation of immunoglobulin genes
.nucleotide-excision repair
.DNA replication
.metal ion binding
.lyase activity
.DNA-directed DNA polymerase activity
.DNA binding
.nucleus
72 EBI-1105213,EBI-751683 SAP30BP  
  .negative regulation of gene expression, epigenetic
.regulation of gene expression, epigenetic
.positive regulation of cell death
  + 4 more...
.N/A .intermediate filament cytoskeleton
.nucleoplasm
.nucleus
73 EBI-1105213,EBI-308511 TSPYL4  
  .nucleosome assembly .N/A .nucleus
74 EBI-1105213,EBI-746704 HOOK1  
  .early endosome to late endosome transport
.protein transport
.endosome to lysosome transport
  + 4 more...
.identical protein binding .FHF complex
.microtubule
75 EBI-1105213,EBI-2836773 CCNL1  
  .RNA processing
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.regulation of cyclin-dependent protein serine/threonine kinase activity
.N/A .nuclear speck
.nucleus
76 EBI-1105213,EBI-725252 NFU1  
  .iron-sulfur cluster assembly .4 iron, 4 sulfur cluster binding
.iron ion binding
.cytosol
.mitochondrion
.cytoplasm
  + 2 more...
77 EBI-1105213,EBI-765817 TRAF3IP3  
  .N/A .N/A .integral component of membrane
78 EBI-1105213,EBI-742802 FAM50B  
  .N/A .N/A .nucleus
79 EBI-1105213,EBI-2212028 SSX2IP  
  .regulation of cell motility
.centrosome organization
.cilium assembly
  + 3 more...
.N/A .protein complex
.ciliary basal body
.centriolar satellite
  + 3 more...
80 EBI-1105213,EBI-2623095 SH3GLB1  
  .positive regulation of autophagic vacuole assembly
.positive regulation of protein targeting to mitochondrion
.protein localization to vacuolar membrane
  + 11 more...
.protein homodimerization activity
.identical protein binding
.lipid binding
.extracellular exosome
.midbody
.mitochondrial outer membrane
  + 3 more...
81 EBI-1105213,EBI-7223720 RRP7A  
  .rRNA processing
.ribosomal small subunit assembly
.poly(A) RNA binding
.nucleotide binding
.UTP-C complex
.CURI complex
82 EBI-1105213,EBI-750484 FAM115A  
  .positive regulation of anion channel activity
.positive regulation of protein targeting to membrane
.negative regulation of cell migration
.transport
.ion channel binding .plasma membrane
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
ascites125
bladder33
blood98
bone marrow102
brain73
cervix61
connective tissue46
embryonic tissue37
eye28
heart11
intestine64
kidney94
liver73
lung44
lymph node44
mammary gland59
mouth181
muscle9
nerve64
ovary98
pancreas18
pharynx24
pituitary gland121
placenta74
prostate21
skin113
spleen112
stomach31
testis176
thymus50
thyroid64
trachea19
uterus77
vascular96
Health State
TissuesTPM*
normal63
breast (mammary gland) tumor64
cervical tumor86
chondrosarcoma120
colorectal tumor44
gastrointestinal tumor50
germ cell tumor79
glioma46
head and neck tumor89
kidney tumor145
leukemia84
liver tumor93
lung tumor19
lymphoma55
non-neoplasia62
ovarian tumor78
pancreatic tumor9
primitive neuroectodermal tumor of the CNS118
prostate cancer9
skin tumor127
soft tissue/muscle tissue tumor15
uterine tumor99
Developmental Stage
TissuesTPM*
adult54
embryoid body28
blastocyst65
neonate193
fetus84
infant127
juvenile125
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue12.7
adrenal gland12.5
appendix20.8
bone marrow41.2
cerebral cortex15.3
colon13.7
duodenum15.5
esophagus16.7
gallbladder15.8
heart muscle13.3
kidney17.2
liver10.7
lung15.7
lymph node26.2
ovary14.7
pancreas9.4
placenta14.4
prostate12.1
salivary gland8.8
skin20.9
small intestine13
spleen18.7
stomach13
testis33.4
thyroid gland18.9
urinary bladder18.5
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*612747, gene) Tuftelin-interacting protein 11; TFIP11OMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center