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	> Protein (NX_Q9UBE8) Protein (NX_Q9UBE8) Protein Gene Symbol NLK to neXtProt (NX_Q9UBE8) Description Serine/threonine-protein kinase NLK Chromosome 17 Location 17q11.2 (26368763 ~ 26523407) to Ensembl Sequene Features : Isoforms 1, Variants 47, PTMs 2 to neXtProt Sequence Features Gene Ontologies GO: Biological Process GO: Mulecular Function GO: Cellular Component .protein autophosphorylation .intracellular signal transduction .serine phosphorylation of STAT3 protein   + 8 more... .SH2 domain binding .ubiquitin protein ligase binding .transcription factor binding   + 5 more... .cytosol .nucleoplasm .nucleus Proteomic Evidences Release Protein Evidence Pr Ab Isoforms Variants PTMs 2015-01-01 protein level 1 47 2 2014-09-19 protein level 1 36 2 2014-05-27 protein level 1 36 2 2014-02-25 protein level 1 36 2 2013-12-09 protein level 1 30 2 2013-11-01 protein level 1 30 2 2013-09-12 protein level 1 30 2 2013-08-17 protein level 1 30 2 2013-07-15 protein level 1 16 2 2013-06-11 protein level 1 16 2 2013-02-12 protein level 1 8 2 2012-12-20 protein level 1 8 2 2012-10-30 protein level 1 9 2 2012-10-07 protein level 1 9 2 2012-08-24 protein level 1 9 2 2012-07-28 protein level 1 9 2 2012-06-08 protein level 1 11 2 2012-05-07 protein level 1 6 2 2012-04-10 protein level 1 6 2 2012-01-13 protein level 1 9 2 2011-12-20 protein level 1 9 2 2011-11-11 protein level 1 9 2 2011-08-23 protein level 1 8 4 Protein Isoforms Isoform Ac   U G S Mw (Da) NX_Q9UBE8-1 21 0 1 58245.3499 : Uniquely mapped peptide : Gene-specific peptide : Shared peptide Interacting Partners No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component 1 EBI-366978,EBI-358684 MAP3K7     .negative regulation of apoptotic signaling pathway .regulation of reactive oxygen species metabolic process .negative regulation of ripoptosome assembly involved in necroptotic process   + 37 more... .scaffold protein binding .ATP binding .MAP kinase kinase kinase activity   + 4 more... .endosome membrane .plasma membrane .cytosol   + 4 more... 2 EBI-366978,EBI-3958099 KRTAP5-9     .epidermis development .N/A .keratin filament 3 EBI-366978,EBI-747754 GRN     .positive regulation of epithelial cell proliferation .embryo implantation .signal transduction .blastocyst hatching .poly(A) RNA binding .growth factor activity .extracellular exosome .intracellular membrane-bounded organelle .mitochondrion .extracellular space 4 EBI-366978,EBI-347263 SMAD4     .nephrogenic mesenchyme morphogenesis .metanephric mesenchyme morphogenesis .response to transforming growth factor beta   + 49 more... .R-SMAD binding .I-SMAD binding .metal ion binding   + 9 more... .SMAD protein complex .activin responsive factor complex .cytosol   + 6 more... 5 EBI-366978,EBI-749713 TFDP1     .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway .intrinsic apoptotic signaling pathway .negative regulation of fat cell proliferation   + 12 more... .protein domain specific binding .transcription factor binding .transcription coactivator activity   + 3 more... .transcription factor complex .nucleoplasm 6 EBI-366978,EBI-2798044 QRICH1     .N/A .N/A .nucleoplasm 7 EBI-366978,EBI-10250562 KRTAP5-6     .N/A .N/A .keratin filament 8 EBI-366978,EBI-947779 RCHY1     .error-free translesion synthesis .protein autoubiquitination .protein ubiquitination involved in ubiquitin-dependent protein catabolic process   + 5 more... .protein homodimerization activity .ligase activity .zinc ion binding   + 2 more... .nuclear speck .cytoplasm .nucleoplasm   + 2 more... 9 EBI-366978,EBI-10172511 KRTAP4-2     .N/A .N/A .keratin filament 10 EBI-366978,EBI-948582 ZHX3     .negative regulation of transcription, DNA-templated .positive regulation of osteoblast differentiation .cell differentiation   + 2 more... .protein heterodimerization activity .metal ion binding .protein homodimerization activity   + 3 more... .nucleoplasm .nucleus EST expression level of Protein Coding Gene (ref. NCBI UniGene EST) Body Sites Tissues TPM* bladder 33 blood 8 bone 27 bone marrow 20 brain 33 cervix 20 connective tissue 13 embryonic tissue 42 eye 148 heart 11 intestine 34 kidney 52 larynx 42 liver 19 lung 35 lymph node 167 mammary gland 6 mouth 45 muscle 18 parathyroid 339 placenta 10 prostate 26 skin 14 stomach 20 testis 27 thyroid 42 uterus 21 vascular 19 Health State Tissues TPM* normal 30 breast (mammary gland) tumor 10 cervical tumor 28 chondrosarcoma 24 colorectal tumor 62 gastrointestinal tumor 16 germ cell tumor 30 head and neck tumor 44 kidney tumor 29 leukemia 21 liver tumor 20 lung tumor 9 non-neoplasia 113 primitive neuroectodermal tumor of the CNS 7 prostate cancer 9 retinoblastoma 236 skin tumor 7 soft tissue/muscle tissue tumor 7 uterine tumor 22 Developmental Stage Tissues TPM* adult 37 embryoid body 42 blastocyst 32 fetus 17 juvenile 35 TPM*: Transcripts per million; transcript expression level measured by expression sequence tags. Expression level of Protein (ref. Human Protein Atlas) RNA-Seq. Tissues FPKM adipose tissue 7.2 adrenal gland 37.1 appendix 9.6 bone marrow 6.5 cerebral cortex 31.2 colon 9.3 duodenum 10.1 esophagus 6.3 gallbladder 9.8 heart muscle 10.1 kidney 14.2 liver 6.5 lung 9 lymph node 17.4 ovary 5.7 pancreas 6.8 placenta 10.4 prostate 8.1 salivary gland 5.9 skin 5 small intestine 9.8 spleen 12.5 stomach 8.8 testis 24.4 thyroid gland 18.9 urinary bladder 10.7 Cancer Tumor Number of patients and Staining levels breast cancer carcinoid cervical cancer colorectal cancer endometrial cancer glioma head and neck cancer liver cancer lung cancer lymphoma melanoma ovarian cancer pancreatic cancer prostate cancer renal cancer skin cancer stomach cancer testis cancer thyroid cancer urothelial cancer RNA-seq colour codes Highly expressed RNAs (FPKM >50) Moderately expressed RNAs (50> FPKM >10) Lower expressed RNAs (10> FPKM >1) The lowest expressed RNAs (FPKM value of 0 or 1) Staining level colour codes Highly expressed protein Moderately expressed protein Lower expressed protein Not Detected Disease No. Disease Description Ref. 1 (*609476, gene) Nemo-like kinase; NLK OMIM

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