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Protein |
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Gene Symbol | NLK to neXtProt (NX_Q9UBE8) |
Description | Serine/threonine-protein kinase NLK |
Chromosome | 17 |
Location | 17q11.2 (26368763 ~ 26523407) to Ensembl |
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Sequene Features : Isoforms 1, Variants 47, PTMs 2 to neXtProt Sequence Features
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Gene Ontologies |
GO: Biological Process |
GO: Mulecular Function |
GO: Cellular Component |
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.protein autophosphorylation .intracellular signal transduction .serine phosphorylation of STAT3 protein + 8 more... |
.SH2 domain binding .ubiquitin protein ligase binding .transcription factor binding + 5 more... |
.cytosol .nucleoplasm .nucleus |
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Proteomic Evidences |
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Release | | Protein Evidence | | Pr | | Ab | | Isoforms | | Variants | | PTMs |
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2015-01-01 | | protein level | | | | | | | 1 |
| 47 |
| 2 |
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2014-09-19 | | protein level | | | | | | | 1 |
| 36 |
| 2 |
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2014-05-27 | | protein level | | | | | | | 1 |
| 36 |
| 2 |
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2014-02-25 | | protein level | | | | | | | 1 |
| 36 |
| 2 |
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2013-12-09 | | protein level | | | | | | | 1 |
| 30 |
| 2 |
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2013-11-01 | | protein level | | | | | | | 1 |
| 30 |
| 2 |
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2013-09-12 | | protein level | | | | | | | 1 |
| 30 |
| 2 |
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2013-08-17 | | protein level | | | | | | | 1 |
| 30 |
| 2 |
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2013-07-15 | | protein level | | | | | | | 1 |
| 16 |
| 2 |
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2013-06-11 | | protein level | | | | | | | 1 |
| 16 |
| 2 |
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2013-02-12 | | protein level | | | | | | | 1 |
| 8 |
| 2 |
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2012-12-20 | | protein level | | | | | | | 1 |
| 8 |
| 2 |
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2012-10-30 | | protein level | | | | | | | 1 |
| 9 |
| 2 |
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2012-10-07 | | protein level | | | | | | | 1 |
| 9 |
| 2 |
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2012-08-24 | | protein level | | | | | | | 1 |
| 9 |
| 2 |
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2012-07-28 | | protein level | | | | | | | 1 |
| 9 |
| 2 |
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2012-06-08 | | protein level | | | | | | | 1 |
| 11 |
| 2 |
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2012-05-07 | | protein level | | | | | | | 1 |
| 6 |
| 2 |
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2012-04-10 | | protein level | | | | | | | 1 |
| 6 |
| 2 |
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2012-01-13 | | protein level | | | | | | | 1 |
| 9 |
| 2 |
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2011-12-20 | | protein level | | | | | | | 1 |
| 9 |
| 2 |
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2011-11-11 | | protein level | | | | | | | 1 |
| 9 |
| 2 |
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2011-08-23 | | protein level | | | | | | | 1 |
| 8 |
| 4 |
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Protein Isoforms |
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| : Uniquely mapped peptide | | : Gene-specific peptide | | : Shared peptide |
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Interacting Partners |
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No. |
Exp. ref. |
Symbol |
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PE |
Pr |
Ab |
Di |
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GO: Biological Process |
GO: Mulecular Function |
GO: Cellular Component |
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1 |
EBI-366978,EBI-358684 |
MAP3K7 |
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| | | | |
.negative regulation of apoptotic signaling pathway .regulation of reactive oxygen species metabolic process .negative regulation of ripoptosome assembly involved in necroptotic process + 37 more... |
.scaffold protein binding .ATP binding .MAP kinase kinase kinase activity + 4 more... |
.endosome membrane .plasma membrane .cytosol + 4 more... |
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2 |
EBI-366978,EBI-3958099 |
KRTAP5-9 |
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.epidermis development |
.N/A |
.keratin filament |
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3 |
EBI-366978,EBI-747754 |
GRN |
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.positive regulation of epithelial cell proliferation .embryo implantation .signal transduction .blastocyst hatching |
.poly(A) RNA binding .growth factor activity |
.extracellular exosome .intracellular membrane-bounded organelle .mitochondrion .extracellular space |
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4 |
EBI-366978,EBI-347263 |
SMAD4 |
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.nephrogenic mesenchyme morphogenesis .metanephric mesenchyme morphogenesis .response to transforming growth factor beta + 49 more... |
.R-SMAD binding .I-SMAD binding .metal ion binding + 9 more... |
.SMAD protein complex .activin responsive factor complex .cytosol + 6 more... |
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5 |
EBI-366978,EBI-749713 |
TFDP1 |
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.positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway .intrinsic apoptotic signaling pathway .negative regulation of fat cell proliferation + 12 more... |
.protein domain specific binding .transcription factor binding .transcription coactivator activity + 3 more... |
.transcription factor complex .nucleoplasm |
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6 |
EBI-366978,EBI-2798044 |
QRICH1 |
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.N/A |
.N/A |
.nucleoplasm |
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7 |
EBI-366978,EBI-10250562 |
KRTAP5-6 |
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.N/A |
.N/A |
.keratin filament |
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8 |
EBI-366978,EBI-947779 |
RCHY1 |
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.error-free translesion synthesis .protein autoubiquitination .protein ubiquitination involved in ubiquitin-dependent protein catabolic process + 5 more... |
.protein homodimerization activity .ligase activity .zinc ion binding + 2 more... |
.nuclear speck .cytoplasm .nucleoplasm + 2 more... |
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9 |
EBI-366978,EBI-10172511 |
KRTAP4-2 |
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.N/A |
.N/A |
.keratin filament |
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10 |
EBI-366978,EBI-948582 |
ZHX3 |
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.negative regulation of transcription, DNA-templated .positive regulation of osteoblast differentiation .cell differentiation + 2 more... |
.protein heterodimerization activity .metal ion binding .protein homodimerization activity + 3 more... |
.nucleoplasm .nucleus |
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EST expression level of Protein Coding Gene (ref. NCBI UniGene EST) |
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Body Sites | |
Tissues | TPM* | |
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bladder | 33 | |
blood | 8 | |
bone | 27 | |
bone marrow | 20 | |
brain | 33 | |
cervix | 20 | |
connective tissue | 13 | |
embryonic tissue | 42 | |
eye | 148 | |
heart | 11 | |
intestine | 34 | |
kidney | 52 | |
larynx | 42 | |
liver | 19 | |
lung | 35 | |
lymph node | 167 | |
mammary gland | 6 | |
mouth | 45 | |
muscle | 18 | |
parathyroid | 339 | |
placenta | 10 | |
prostate | 26 | |
skin | 14 | |
stomach | 20 | |
testis | 27 | |
thyroid | 42 | |
uterus | 21 | |
vascular | 19 | |
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Health State | |
Tissues | TPM* | |
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normal | 30 | |
breast (mammary gland) tumor | 10 | |
cervical tumor | 28 | |
chondrosarcoma | 24 | |
colorectal tumor | 62 | |
gastrointestinal tumor | 16 | |
germ cell tumor | 30 | |
head and neck tumor | 44 | |
kidney tumor | 29 | |
leukemia | 21 | |
liver tumor | 20 | |
lung tumor | 9 | |
non-neoplasia | 113 | |
primitive neuroectodermal tumor of the CNS | 7 | |
prostate cancer | 9 | |
retinoblastoma | 236 | |
skin tumor | 7 | |
soft tissue/muscle tissue tumor | 7 | |
uterine tumor | 22 | |
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Developmental Stage | |
Tissues | TPM* | |
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adult | 37 | |
embryoid body | 42 | |
blastocyst | 32 | |
fetus | 17 | |
juvenile | 35 | |
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TPM*: Transcripts per million; transcript expression level measured by expression sequence tags. |
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Expression level of Protein (ref. Human Protein Atlas) |
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RNA-Seq. | |
Tissues | FPKM | |
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adipose tissue | 7.2 | |
adrenal gland | 37.1 | |
appendix | 9.6 | |
bone marrow | 6.5 | |
cerebral cortex | 31.2 | |
colon | 9.3 | |
duodenum | 10.1 | |
esophagus | 6.3 | |
gallbladder | 9.8 | |
heart muscle | 10.1 | |
kidney | 14.2 | |
liver | 6.5 | |
lung | 9 | |
lymph node | 17.4 | |
ovary | 5.7 | |
pancreas | 6.8 | |
placenta | 10.4 | |
prostate | 8.1 | |
salivary gland | 5.9 | |
skin | 5 | |
small intestine | 9.8 | |
spleen | 12.5 | |
stomach | 8.8 | |
testis | 24.4 | |
thyroid gland | 18.9 | |
urinary bladder | 10.7 | |
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Cancer | |
Tumor | Number of patients and Staining levels | |
breast cancer | |
carcinoid | |
cervical cancer | |
colorectal cancer | |
endometrial cancer | |
glioma | |
head and neck cancer | |
liver cancer | |
lung cancer | |
lymphoma | |
melanoma | |
ovarian cancer | |
pancreatic cancer | |
prostate cancer | |
renal cancer | |
skin cancer | |
stomach cancer | |
testis cancer | |
thyroid cancer | |
urothelial cancer | |
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RNA-seq colour codes |
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Highly expressed RNAs (FPKM >50) |
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Moderately expressed RNAs (50> FPKM >10) |
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Lower expressed RNAs (10> FPKM >1) |
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The lowest expressed RNAs (FPKM value of 0 or 1) |
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Staining level colour codes |
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Highly expressed protein |
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Moderately expressed protein |
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Lower expressed protein |
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Not Detected |
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Disease |
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No. | Disease Description | Ref. |
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1 | (*609476, gene) Nemo-like kinase; NLK | OMIM |
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