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> Protein (NX_Q9UBE8)
Protein (NX_Q9UBE8)
Protein
Gene SymbolNLK to neXtProt (NX_Q9UBE8)
DescriptionSerine/threonine-protein kinase NLK
Chromosome17
Location17q11.2 (26368763 ~ 26523407) to Ensembl
Sequene Features : Isoforms 1, Variants 47, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.protein autophosphorylation
.intracellular signal transduction
.serine phosphorylation of STAT3 protein
  + 8 more...
.SH2 domain binding
.ubiquitin protein ligase binding
.transcription factor binding
  + 5 more...
.cytosol
.nucleoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 47 2
2014-09-19protein level
1 36 2
2014-05-27protein level
1 36 2
2014-02-25protein level
1 36 2
2013-12-09protein level
1 30 2
2013-11-01protein level
1 30 2
2013-09-12protein level
1 30 2
2013-08-17protein level
1 30 2
2013-07-15protein level
1 16 2
2013-06-11protein level
1 16 2
2013-02-12protein level
1 8 2
2012-12-20protein level
1 8 2
2012-10-30protein level
1 9 2
2012-10-07protein level
1 9 2
2012-08-24protein level
1 9 2
2012-07-28protein level
1 9 2
2012-06-08protein level
1 11 2
2012-05-07protein level
1 6 2
2012-04-10protein level
1 6 2
2012-01-13protein level
1 9 2
2011-12-20protein level
1 9 2
2011-11-11protein level
1 9 2
2011-08-23protein level
1 8 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9UBE8-1
21 0 1 58245.3499
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-366978,EBI-358684 MAP3K7  
  .negative regulation of apoptotic signaling pathway
.regulation of reactive oxygen species metabolic process
.negative regulation of ripoptosome assembly involved in necroptotic process
  + 37 more...
.scaffold protein binding
.ATP binding
.MAP kinase kinase kinase activity
  + 4 more...
.endosome membrane
.plasma membrane
.cytosol
  + 4 more...
2 EBI-366978,EBI-3958099 KRTAP5-9  
  .epidermis development .N/A .keratin filament
3 EBI-366978,EBI-747754 GRN  
  .positive regulation of epithelial cell proliferation
.embryo implantation
.signal transduction
.blastocyst hatching
.poly(A) RNA binding
.growth factor activity
.extracellular exosome
.intracellular membrane-bounded organelle
.mitochondrion
.extracellular space
4 EBI-366978,EBI-347263 SMAD4  
  .nephrogenic mesenchyme morphogenesis
.metanephric mesenchyme morphogenesis
.response to transforming growth factor beta
  + 49 more...
.R-SMAD binding
.I-SMAD binding
.metal ion binding
  + 9 more...
.SMAD protein complex
.activin responsive factor complex
.cytosol
  + 6 more...
5 EBI-366978,EBI-749713 TFDP1  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.negative regulation of fat cell proliferation
  + 12 more...
.protein domain specific binding
.transcription factor binding
.transcription coactivator activity
  + 3 more...
.transcription factor complex
.nucleoplasm
6 EBI-366978,EBI-2798044 QRICH1  
  .N/A .N/A .nucleoplasm
7 EBI-366978,EBI-10250562 KRTAP5-6  
  .N/A .N/A .keratin filament
8 EBI-366978,EBI-947779 RCHY1  
  .error-free translesion synthesis
.protein autoubiquitination
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
  + 5 more...
.protein homodimerization activity
.ligase activity
.zinc ion binding
  + 2 more...
.nuclear speck
.cytoplasm
.nucleoplasm
  + 2 more...
9 EBI-366978,EBI-10172511 KRTAP4-2  
  .N/A .N/A .keratin filament
10 EBI-366978,EBI-948582 ZHX3  
  .negative regulation of transcription, DNA-templated
.positive regulation of osteoblast differentiation
.cell differentiation
  + 2 more...
.protein heterodimerization activity
.metal ion binding
.protein homodimerization activity
  + 3 more...
.nucleoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder33
blood8
bone27
bone marrow20
brain33
cervix20
connective tissue13
embryonic tissue42
eye148
heart11
intestine34
kidney52
larynx42
liver19
lung35
lymph node167
mammary gland6
mouth45
muscle18
parathyroid339
placenta10
prostate26
skin14
stomach20
testis27
thyroid42
uterus21
vascular19
Health State
TissuesTPM*
normal30
breast (mammary gland) tumor10
cervical tumor28
chondrosarcoma24
colorectal tumor62
gastrointestinal tumor16
germ cell tumor30
head and neck tumor44
kidney tumor29
leukemia21
liver tumor20
lung tumor9
non-neoplasia113
primitive neuroectodermal tumor of the CNS7
prostate cancer9
retinoblastoma236
skin tumor7
soft tissue/muscle tissue tumor7
uterine tumor22
Developmental Stage
TissuesTPM*
adult37
embryoid body42
blastocyst32
fetus17
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue7.2
adrenal gland37.1
appendix9.6
bone marrow6.5
cerebral cortex31.2
colon9.3
duodenum10.1
esophagus6.3
gallbladder9.8
heart muscle10.1
kidney14.2
liver6.5
lung9
lymph node17.4
ovary5.7
pancreas6.8
placenta10.4
prostate8.1
salivary gland5.9
skin5
small intestine9.8
spleen12.5
stomach8.8
testis24.4
thyroid gland18.9
urinary bladder10.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*609476, gene) Nemo-like kinase; NLKOMIM


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