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> Protein (NX_Q9UBS5)
Protein (NX_Q9UBS5)
Protein
Gene SymbolGABBR1 to neXtProt (NX_Q9UBS5)
DescriptionGamma-aminobutyric acid type B receptor subunit 1
Chromosome6
Location6p22.1 (29523406 ~ 29601753) to Ensembl
Sequene Features : Isoforms 5, Variants 94, PTMs 11 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.synaptic transmission
.gamma-aminobutyric acid signaling pathway
.negative regulation of adenylate cyclase activity
.adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
.G-protein coupled GABA receptor activity .postsynaptic membrane
.presynaptic membrane
.G-protein coupled receptor heterodimeric complex
  + 6 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
5 94 11
2014-09-19protein level
5 65 11
2014-05-27protein level
5 65 11
2014-02-25protein level
5 15 9
2013-12-09protein level
5 7 9
2013-11-01protein level
5 7 9
2013-09-12protein level
5 7 10
2013-08-17protein level
5 7 10
2013-07-15protein level
5 7 10
2013-06-11protein level
5 7 10
2013-02-12protein level
5 7 42
2012-12-20protein level
5 8 42
2012-10-30protein level
5 10 42
2012-10-07protein level
5 10 10
2012-08-24protein level
5 10 10
2012-07-28protein level
5 10 10
2012-06-08protein level
5 20 10
2012-05-07protein level
5 20 10
2012-04-10protein level
5 18 10
2012-01-13protein level
5 13 10
2011-12-20protein level
5 13 10
2011-11-11protein level
5 22 10
2011-08-23protein level
5 22 10
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9UBS5-1
0 41 0 108251.2126
NX_Q9UBS5-2
3 34 0 95087.7479
NX_Q9UBS5-3
0 37 0 101477.9165
NX_Q9UBS5-4
1 40 0 104598.2716
NX_Q9UBS5-5
0 26 0 65040.5929
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-724156,EBI-715469 GABBR2  
  .synaptic transmission
.gamma-aminobutyric acid signaling pathway
.negative regulation of adenylate cyclase activity
.G-protein coupled receptor signaling pathway
.G-protein coupled GABA receptor activity .postsynaptic membrane
.neuron projection
.G-protein coupled receptor heterodimeric complex
  + 4 more...
2 EBI-724156,EBI-389883 NCK1  
  .negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.negative regulation of PERK-mediated unfolded protein response
  + 23 more...
.eukaryotic initiation factor eIF2 binding
.receptor tyrosine kinase binding
.protein binding, bridging
  + 5 more...
.vesicle membrane
.cell-cell junction
.plasma membrane
  + 6 more...
3 EBI-724156,EBI-712251 NSF  
  .Golgi vesicle docking
.ATP metabolic process
.positive regulation of protein catabolic process
  + 10 more...
.metal ion binding
.ATPase activity, coupled
.protein complex binding
  + 6 more...
.extracellular exosome
.dendritic shaft
.postsynaptic density
  + 5 more...
4 EBI-724156,EBI-751711 MAX  
  .cellular response to peptide hormone stimulus
.retina development in camera-type eye
.neuron apoptotic process
  + 6 more...
.sequence-specific DNA binding
.transcription coactivator activity
.transcription cofactor activity
.sequence-specific DNA binding transcription factor activity
.MLL1 complex
.dendrite
.PML body
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
bladder200
blood8
bone13
brain579
connective tissue20
embryonic tissue56
eye67
heart11
intestine8
kidney28
larynx85
liver19
lung26
lymph node11
mammary gland112
mouth166
muscle47
nerve386
ovary29
pharynx24
placenta10
prostate58
salivary gland49
skin4
spleen74
stomach10
testis11
thyroid85
trachea19
uterus43
vascular19
Health State
TissuesTPM*
normal200
bladder carcinoma284
breast (mammary gland) tumor75
chondrosarcoma12
colorectal tumor17
germ cell tumor45
glioma233
head and neck tumor134
kidney tumor87
liver tumor20
non-neoplasia20
ovarian tumor39
prostate cancer67
soft tissue/muscle tissue tumor15
uterine tumor22
Developmental Stage
TissuesTPM*
adult71
embryoid body42
blastocyst65
fetus87
juvenile125
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue22.7
adrenal gland28.2
appendix20
bone marrow14.7
cerebral cortex149.6
colon11.5
duodenum8.2
esophagus13.3
gallbladder23.1
heart muscle17.6
kidney10.2
liver2.6
lung26.6
lymph node19.9
ovary30.4
pancreas4.6
placenta12.1
prostate35.6
salivary gland13.5
skin30.4
small intestine13.4
spleen52
stomach13.6
testis11.2
thyroid gland16.5
urinary bladder13.9
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603540, gene) Gamma-aminobutyric acid b receptor 1; GABBR1OMIM


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