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> Protein (NX_Q9UBU8)
Protein (NX_Q9UBU8)
Protein
Gene SymbolMORF4L1 to neXtProt (NX_Q9UBU8)
DescriptionMortality factor 4-like protein 1
Chromosome15
Location15q25.1 (79102829 ~ 79190475) to Ensembl
Sequene Features : Isoforms 3, Variants 39, PTMs 14 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.histone H2A acetylation
.histone H4 acetylation
.regulation of growth
  + 6 more...
.protein N-terminus binding
.chromatin binding
.NuA4 histone acetyltransferase complex
.Sin3 complex
.nucleoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 39 14
2014-09-19protein level
3 30 14
2014-05-27protein level
3 30 14
2014-02-25protein level
3 30 14
2013-12-09protein level
3 25 14
2013-11-01protein level
3 25 11
2013-09-12protein level
3 25 11
2013-08-17protein level
3 25 11
2013-07-15protein level
3 13 4
2013-06-11protein level
3 13 4
2013-02-12protein level
2 6 8
2012-12-20protein level
2 6 8
2012-10-30protein level
2 7 8
2012-10-07protein level
2 7 4
2012-08-24protein level
2 7 4
2012-07-28protein level
2 7 4
2012-06-08protein level
2 13 4
2012-05-07protein level
2 11 4
2012-04-10protein level
2 11 4
2012-01-13protein level
2 10 4
2011-12-20protein level
2 10 4
2011-11-11protein level
2 10 4
2011-08-23protein level
2 10 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9UBU8-1
1 12 3 41447.5055
NX_Q9UBU8-2
1 12 3 37207.1949
NX_Q9UBU8-3
0 8 3 26732.863
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-399246,EBI-726527 TNNT1  
  .negative regulation of muscle contraction
.slow-twitch skeletal muscle fiber contraction
.muscle filament sliding
.skeletal muscle contraction
.tropomyosin binding .troponin complex
.cytosol
2 EBI-399246,EBI-2864512 MEOX1  
  .sclerotome development
.somite development
.hematopoietic stem cell differentiation
  + 2 more...
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.chromatin binding
  + 3 more...
.cytoplasm
.nucleus
3 EBI-399246,EBI-740459 FXR2  
  .negative regulation of translation
.positive regulation of defense response to virus by host
.poly(A) RNA binding
.identical protein binding
.mRNA binding
.RNA binding
.extracellular exosome
.cytosolic large ribosomal subunit
.membrane
  + 3 more...
4 EBI-399246,EBI-307352 REL  
  .negative regulation of neuron death
.positive regulation of transcription from RNA polymerase II promoter
.innate immune response
  + 10 more...
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II distal enhancer sequence-specific DNA binding
.I-kappaB/NF-kappaB complex
.cytosol
.transcription factor complex
  + 2 more...
5 EBI-399246,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
6 EBI-10288852,EBI-717422 TFCP2  
  .regulation of transcription from RNA polymerase II promoter
.transcription, DNA-templated
.sequence-specific DNA binding
.protein C-terminus binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
7 EBI-399246,EBI-745305 IKZF1  
  .retina development in camera-type eye
.positive regulation of NK T cell differentiation
.Peyer's patch development
  + 17 more...
.metal ion binding
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.protein complex
.cytoplasm
.pericentric heterochromatin
.nucleus
8 EBI-399246,EBI-1058722 CAMK2B  
  .positive regulation of apoptotic signaling pathway
.regulation of cellular response to heat
.positive regulation of synapse maturation
  + 22 more...
.protein homodimerization activity
.ATP binding
.calmodulin-dependent protein kinase activity
.spindle midzone
.sarcoplasmic reticulum membrane
.endocytic vesicle membrane
  + 4 more...
9 EBI-399246,EBI-357849 TNIP1  
  .modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade
.negative regulation of ERK1 and ERK2 cascade
.positive regulation of inflammatory response
  + 9 more...
.mitogen-activated protein kinase binding .cytoplasm
.nucleus
.intracellular
10 EBI-399246,EBI-8641936 NAB2  
  .regulation of epidermis development
.myelination
.negative regulation of transcription from RNA polymerase III promoter
  + 5 more...
.transcription corepressor activity .nucleus
11 EBI-399246,EBI-2549423 HMBOX1  
  .positive regulation of transcription, DNA-templated
.negative regulation of transcription, DNA-templated
.transcription, DNA-templated
.DNA binding .cytoplasm
.nucleoplasm
.nucleus
12 EBI-399246,EBI-741200 NAV2  
  .vagus nerve development
.glossopharyngeal nerve development
.optic nerve development
  + 4 more...
.heparin binding
.ATP binding
.helicase activity
.nucleoplasm
.interstitial matrix
13 EBI-399246,EBI-10181988 CEP57L1  
  .microtubule anchoring .N/A .microtubule
.microtubule organizing center
.cytoplasm
14 EBI-399246,EBI-10175124 FAM9B  
  .spermatid development .N/A .nucleoplasm
15 EBI-399246,EBI-10181188 BEND7  
  .N/A .N/A .extracellular exosome
16 EBI-399246,EBI-725997 TRIM41  
  .protein ubiquitination .ligase activity
.zinc ion binding
.cytoplasm
.nucleolus
17 EBI-10288852,EBI-740845 PBXIP1  
  .negative regulation of transcription, DNA-templated
.cell differentiation
.multicellular organismal development
.transcription corepressor activity .microtubule
.cytosol
.nucleus
18 EBI-10288852,EBI-2875665 ARRDC3  
  .negative regulation of locomotion involved in locomotory behavior
.positive regulation of adrenergic receptor signaling pathway
.fat pad development
  + 5 more...
.beta-3 adrenergic receptor binding .plasma membrane
.endosome
19 EBI-399246,EBI-395708 ZBTB9  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
20 EBI-399246,EBI-10235384 ZBTB10  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleoplasm
21 EBI-399246,EBI-748896 MRFAP1L1  
  .N/A .identical protein binding .N/A
22 EBI-399246,EBI-2686809 L3MBTL3  
  .erythrocyte maturation
.granulocyte differentiation
.macrophage differentiation
  + 3 more...
.N/A .nucleus
23 EBI-10288852,EBI-10293106 PHF12  
  .negative regulation of transcription, DNA-templated
.negative regulation of transcription from RNA polymerase II promoter
.phosphatidylinositol binding
.zinc ion binding
.RNA polymerase II transcription corepressor activity
.transcriptional repressor complex
.Sin3 complex
.nucleolus
  + 2 more...
24 EBI-399246,EBI-741037 LZTS2  
  .negative regulation of protein localization to nucleus
.negative regulation of canonical Wnt signaling pathway
.spindle midzone assembly
  + 7 more...
.N/A .midbody
.microtubule
.centrosome
.cytoplasm
25 EBI-399246,EBI-717233 RACGAP1  
  .regulation of attachment of spindle microtubules to kinetochore
.mitotic spindle midzone assembly
.regulation of small GTPase mediated signal transduction
  + 12 more...
.beta-tubulin binding
.metal ion binding
.gamma-tubulin binding
  + 5 more...
.centralspindlin complex
.mitotic spindle
.extracellular exosome
  + 9 more...
26 EBI-399246,EBI-399076 MRGBP  
  .regulation of growth
.chromatin modification
.regulation of transcription, DNA-templated
  + 2 more...
.N/A .H4/H2A histone acetyltransferase complex
.nucleoplasm
.nucleus
27 EBI-399246,EBI-741515 THAP1  
  .regulation of mitotic cell cycle
.cell cycle
.regulation of transcription, DNA-templated
  + 2 more...
.sequence-specific DNA binding
.identical protein binding
.zinc ion binding
.PML body
.nucleus
28 EBI-399246,EBI-995714 MRFAP1  
  .N/A .N/A .perinuclear region of cytoplasm
.nucleoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland364
ascites301
bladder368
blood220
bone377
bone marrow287
brain300
cervix309
connective tissue167
ear496
embryonic tissue615
esophagus396
eye287
heart435
intestine176
kidney161
larynx85
liver194
lung164
lymph225
lymph node144
mammary gland231
mouth45
muscle244
nerve321
ovary187
pancreas365
parathyroid145
pharynx270
pituitary gland484
placenta268
prostate189
salivary gland148
skin374
spleen56
stomach167
testis351
thymus62
thyroid364
tonsil293
trachea38
umbilical cord72
uterus305
vascular329
Health State
TissuesTPM*
normal242
adrenal tumor395
bladder carcinoma284
breast (mammary gland) tumor225
cervical tumor405
chondrosarcoma374
colorectal tumor159
esophageal tumor405
gastrointestinal tumor286
germ cell tumor288
glioma121
head and neck tumor156
kidney tumor246
leukemia158
liver tumor187
lung tumor136
lymphoma180
non-neoplasia362
ovarian tumor196
pancreatic tumor342
primitive neuroectodermal tumor of the CNS346
prostate cancer288
retinoblastoma409
skin tumor406
soft tissue/muscle tissue tumor335
uterine tumor277
Developmental Stage
TissuesTPM*
adult211
embryoid body528
blastocyst423
neonate32
fetus208
infant723
juvenile341
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue58.1
adrenal gland82.5
appendix53.7
bone marrow62.7
cerebral cortex75.4
colon55.1
duodenum38.1
esophagus36.3
gallbladder57.5
heart muscle65.7
kidney69
liver34.7
lung59.7
lymph node52.5
ovary78.7
pancreas17.8
placenta71.4
prostate59.8
salivary gland33.4
skin27
small intestine41.2
spleen52.4
stomach44.5
testis84.2
thyroid gland53.5
urinary bladder57.2
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*607303, gene) Mortality factor 4-like protein 1; MORF4L1OMIM


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