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> Protein (NX_Q9UBU9)
Protein (NX_Q9UBU9)
Protein
Gene SymbolNXF1 to neXtProt (NX_Q9UBU9)
DescriptionNuclear RNA export factor 1
Chromosome11
Location11q12.3 (62559595 ~ 62573774) to Ensembl
Sequene Features : Isoforms 2, Variants 72, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.poly(A)+ mRNA export from nucleus
.viral process
.gene expression
.mRNA export from nucleus
.poly(A) RNA binding
.nucleocytoplasmic transporter activity
.mRNA binding
.nucleotide binding
.nuclear inclusion body
.nuclear speck
.cytosol
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 72 7
2014-09-19protein level
2 49 7
2014-05-27protein level
2 49 7
2014-02-25protein level
2 49 7
2013-12-09protein level
2 45 7
2013-11-01protein level
2 42 6
2013-09-12protein level
2 42 6
2013-08-17protein level
2 42 6
2013-07-15protein level
2 32 2
2013-06-11protein level
2 32 2
2013-02-12protein level
2 15 2
2012-12-20protein level
2 15 2
2012-10-30protein level
2 14 2
2012-10-07protein level
2 14 1
2012-08-24protein level
2 4 1
2012-07-28protein level
2 4 1
2012-06-08protein level
2 16 1
2012-05-07protein level
2 16 1
2012-04-10protein level
2 16 1
2012-01-13protein level
2 17 1
2011-12-20protein level
2 17 1
2011-11-11protein level
2 17 1
2011-08-23protein level
2 17 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9UBU9-1
14 15 0 70138.4831
NX_Q9UBU9-2
1 15 0 40450.5491
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-398874,EBI-353779 DDX3X  
  .negative regulation of intrinsic apoptotic signaling pathway
.positive regulation of G1/S transition of mitotic cell cycle
.intrinsic apoptotic signaling pathway
  + 28 more...
.mRNA 5'-UTR binding
.poly(A) RNA binding
.CTPase activity
  + 14 more...
.extracellular exosome
.nuclear speck
.cytoplasmic stress granule
  + 4 more...
2 EBI-398874,EBI-740738 LDOC1  
  .negative regulation of cell proliferation .N/A .nucleolus
.nucleus
3 EBI-398874,EBI-744302 GFAP  
  .long-term synaptic potentiation
.Bergmann glial cell differentiation
.regulation of neurotransmitter uptake
  + 7 more...
.structural constituent of cytoskeleton .astrocyte end-foot
.cell body
.membrane
  + 3 more...
4 EBI-398874,EBI-347978 NUP62  
  .regulation of cellular response to heat
.transmembrane transport
.mRNA transport
  + 34 more...
.thyroid hormone receptor binding
.ubiquitin binding
.SH2 domain binding
  + 3 more...
.Flemming body
.pore complex
.intracellular membrane-bounded organelle
  + 7 more...
5 EBI-398874,EBI-372557 SRSF3  
  .mRNA 3'-end processing
.gene expression
.RNA splicing
  + 4 more...
.poly(A) RNA binding
.RNA binding
.nucleotide binding
.cytoplasm
.nucleoplasm
6 EBI-398874,EBI-398920 SRSF1  
  .cardiac muscle contraction
.regulation of mRNA splicing, via spliceosome
.regulation of mRNA stability
  + 13 more...
.poly(A) RNA binding
.mRNA binding
.RNA binding
.nucleotide binding
.catalytic step 2 spliceosome
.extracellular exosome
.nuclear speck
  + 3 more...
7 EBI-398874,EBI-352022 DHX9  
  .CRD-mediated mRNA stabilization
.innate immune response
.cellular response to heat
  + 8 more...
.poly(A) RNA binding
.ATP binding
.ATP-dependent RNA helicase activity
  + 4 more...
.CRD-mediated mRNA stability complex
.cytoplasmic ribonucleoprotein granule
.ribonucleoprotein complex
  + 7 more...
8 EBI-398874,EBI-10175039 TP53BP2  
  .positive regulation of execution phase of apoptosis
.intrinsic apoptotic signaling pathway by p53 class mediator
.negative regulation of cell cycle
  + 7 more...
.NF-kappaB binding
.identical protein binding
.SH3/SH2 adaptor activity
.p53 binding
.perinuclear region of cytoplasm
.cytoplasm
.nucleus
9 EBI-398874,EBI-398885 SRSF7  
  .negative regulation of mRNA splicing, via spliceosome
.mRNA 3'-end processing
.gene expression
  + 6 more...
.poly(A) RNA binding
.zinc ion binding
.nucleotide binding
.extracellular exosome
.cytoplasm
.nucleoplasm
.nucleus
10 EBI-398874,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
11 EBI-398874,EBI-347640 ALYREF  
  .viral mRNA export from host cell nucleus
.positive regulation of DNA-templated transcription, elongation
.replication fork processing
  + 9 more...
.poly(A) RNA binding
.nucleotide binding
.catalytic step 2 spliceosome
.extracellular exosome
.intracellular membrane-bounded organelle
  + 6 more...
12 EBI-398874,EBI-739789 DVL3  
  .positive regulation of canonical Wnt signaling pathway
.planar cell polarity pathway involved in neural tube closure
.cochlea morphogenesis
  + 12 more...
.protein heterodimerization activity
.beta-catenin binding
.frizzled binding
  + 2 more...
.cytosol
13 EBI-398874,EBI-740711 TIFA  
  .I-kappaB kinase/NF-kappaB signaling .N/A .N/A
14 EBI-398874,EBI-10172526 MID2  
  .negative regulation of viral release from host cell
.positive regulation of NF-kappaB transcription factor activity
.positive regulation of sequence-specific DNA binding transcription factor activity
  + 6 more...
.phosphoprotein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.extracellular exosome
.microtubule
.cytoplasm
15 EBI-398874,EBI-301889 NXT1  
  .protein export from nucleus
.RNA export from nucleus
.N/A .nuclear speck
.cytoplasm
.nuclear pore
16 EBI-398874,EBI-352039 THRAP3  
  .rhythmic process
.mRNA stabilization
.positive regulation of mRNA splicing, via spliceosome
  + 10 more...
.phosphoprotein binding
.thyroid hormone receptor binding
.poly(A) RNA binding
  + 8 more...
.extracellular exosome
.mediator complex
.nucleoplasm
.nucleus
17 EBI-398874,EBI-347794 CHTOP  
  .positive regulation of helicase activity
.positive regulation of ATPase activity
.mRNA export from nucleus
  + 2 more...
.poly(A) RNA binding .intracellular membrane-bounded organelle
.nuclear speck
.nucleolus
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue310
adrenal gland121
ascites301
bladder167
blood237
bone97
bone marrow164
brain343
cervix123
connective tissue120
ear186
embryonic tissue56
esophagus49
eye52
heart100
intestine142
kidney151
liver136
lung101
lymph45
lymph node144
mammary gland105
mouth272
muscle75
nerve128
ovary147
pancreas65
parathyroid194
pharynx98
pituitary gland60
placenta236
prostate100
skin147
spleen412
stomach114
testis243
thymus1154
thyroid279
tonsil293
trachea965
umbilical cord72
uterus430
vascular77
Health State
TissuesTPM*
normal209
adrenal tumor79
bladder carcinoma227
breast (mammary gland) tumor118
cervical tumor57
chondrosarcoma36
colorectal tumor97
gastrointestinal tumor151
germ cell tumor216
glioma214
head and neck tumor179
kidney tumor101
leukemia285
liver tumor177
lung tumor68
lymphoma69
non-neoplasia134
ovarian tumor144
pancreatic tumor76
primitive neuroectodermal tumor of the CNS267
prostate cancer86
retinoblastoma21
skin tumor47
soft tissue/muscle tissue tumor15
uterine tumor233
Developmental Stage
TissuesTPM*
adult177
embryoid body85
blastocyst32
neonate386
fetus145
infant255
juvenile215
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue44.5
adrenal gland58.1
appendix51
bone marrow143.8
cerebral cortex27.7
colon33.2
duodenum36.6
esophagus36.7
gallbladder59.3
heart muscle28
kidney33
liver23.3
lung53.3
lymph node74.7
ovary59.7
pancreas22.3
placenta63.5
prostate54.5
salivary gland37.8
skin82.3
small intestine43.2
spleen68
stomach35.2
testis39.3
thyroid gland51.7
urinary bladder48.2
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowHigh
breastHigh
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1High
endometrium 2High
epididymisHigh
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleMedium
hippocampusMedium
kidneyHigh
lateral ventricleHigh
liverHigh
lungHigh
lymph nodeHigh
nasopharynxHigh
oral mucosaMedium
ovaryHigh
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateMedium
rectumHigh
salivary glandHigh
seminal vesicleHigh
skeletal muscleHigh
skin 1High
skin 2High
small intestineHigh
smooth muscleMedium
soft tissue 1High
soft tissue 2High
spleenHigh
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602647, gene) Nuclear rna export factor 1; NXF1OMIM


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