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> Protein (NX_Q9UBV8)
Protein (NX_Q9UBV8)
Protein
Gene SymbolPEF1 to neXtProt (NX_Q9UBV8)
DescriptionPeflin
Chromosome1
Location1p35.2 (32095463 ~ 32110497) to Ensembl
Sequene Features : Isoforms 1, Variants 37, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.response to calcium ion
.proteolysis
.protein dimerization activity
.protein heterodimerization activity
.poly(A) RNA binding
  + 2 more...
.extracellular exosome
.membrane
.cytoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 37 1
2014-09-19protein level
1 27 1
2014-05-27protein level
1 27 1
2014-02-25protein level
1 27 1
2013-12-09protein level
1 23 1
2013-11-01protein level
1 23 1
2013-09-12protein level
1 23 1
2013-08-17protein level
1 23 1
2013-07-15protein level
1 14 1
2013-06-11protein level
1 14 1
2013-02-12protein level
1 9 0
2012-12-20protein level
1 9 0
2012-10-30protein level
1 8 0
2012-10-07protein level
1 8 0
2012-08-24protein level
1 7 0
2012-07-28protein level
1 7 0
2012-06-08protein level
1 7 0
2012-05-07protein level
1 7 0
2012-04-10protein level
1 7 0
2012-01-13protein level
1 1 0
2011-12-20protein level
1 1 0
2011-11-11protein level
1 1 0
2011-08-23protein level
1 1 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9UBV8-1
9 0 0 30361.2236
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-724639,EBI-740220 HGS  
  .positive regulation of exosomal secretion
.protein localization to membrane
.membrane organization
  + 13 more...
.metal ion binding
.protein domain specific binding
.extracellular exosome
.intracellular membrane-bounded organelle
.multivesicular body membrane
  + 6 more...
2 EBI-724639,EBI-352915 PDCD6  
  .apoptotic signaling pathway
.negative regulation of protein kinase B signaling
.response to calcium ion
  + 12 more...
.binding, bridging
.calcium-dependent protein binding
.protein dimerization activity
  + 4 more...
.endoplasmic reticulum exit site
.extracellular exosome
.nuclear membrane
  + 6 more...
3 EBI-724639,EBI-739737 EWSR1  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.poly(A) RNA binding
.identical protein binding
.zinc ion binding
  + 2 more...
.plasma membrane
.cytoplasm
.nucleolus
  + 2 more...
4 EBI-724639,EBI-739580 CALCOCO2  
  .response to interferon-gamma
.viral process
.protein homodimerization activity .perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.membrane
  + 4 more...
5 EBI-724639,EBI-724310 DAZAP2  
  .N/A .WW domain binding .cytoplasm
.nucleus
6 EBI-724639,EBI-740929 KLHL12  
  .negative regulation of canonical Wnt signaling pathway
.COPII vesicle coating
.Wnt signaling pathway
  + 2 more...
.N/A .Cul3-RING ubiquitin ligase complex
.ER to Golgi transport vesicle
.cytosol
.Golgi membrane
7 EBI-724639,EBI-8468543 FOXR2  
  .cell differentiation
.anatomical structure morphogenesis
.transcription from RNA polymerase II promoter
.regulation of transcription from RNA polymerase II promoter
.sequence-specific DNA binding
.sequence-specific DNA binding RNA polymerase II transcription factor activity
.nucleus
8 EBI-724639,EBI-357061 TFG  
  .positive regulation of I-kappaB kinase/NF-kappaB signaling
.signal transduction
.signal transducer activity .extracellular exosome
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland121
ascites150
bladder33
blood65
bone97
bone marrow123
brain144
cervix103
connective tissue87
embryonic tissue61
esophagus148
eye90
heart111
intestine120
kidney75
liver77
lung122
lymph112
lymph node89
mammary gland92
mouth15
muscle28
nerve128
ovary68
pancreas56
pituitary gland60
placenta240
prostate105
salivary gland197
skin37
spleen112
stomach83
testis103
thymus87
thyroid128
tonsil235
uterus103
vascular77
Health State
TissuesTPM*
normal105
adrenal tumor79
breast (mammary gland) tumor96
cervical tumor144
chondrosarcoma108
colorectal tumor97
gastrointestinal tumor135
germ cell tumor136
glioma46
head and neck tumor37
kidney tumor43
leukemia74
liver tumor145
lung tumor175
lymphoma263
non-neoplasia269
ovarian tumor26
pancreatic tumor95
primitive neuroectodermal tumor of the CNS181
prostate cancer115
retinoblastoma86
skin tumor39
soft tissue/muscle tissue tumor71
uterine tumor110
Developmental Stage
TissuesTPM*
adult123
embryoid body28
blastocyst113
fetus61
infant297
juvenile143
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue34.8
adrenal gland44.6
appendix34.3
bone marrow25.5
cerebral cortex33.7
colon40.1
duodenum28.1
esophagus51.6
gallbladder44.7
heart muscle43.6
kidney37.8
liver24.6
lung50.6
lymph node38.5
ovary41
pancreas18.5
placenta62.5
prostate36.5
salivary gland27.7
skin55.2
small intestine27.8
spleen37.8
stomach25.3
testis34.6
thyroid gland125.1
urinary bladder51.3
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*610033, gene) Penta-ef-hand domain-containing protein 1; PEF1OMIM


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