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> Protein (NX_Q9UBY9)
Protein (NX_Q9UBY9)
Protein
Gene SymbolHSPB7 to neXtProt (NX_Q9UBY9)
DescriptionHeat shock protein beta-7
Chromosome1
Location1p36.13 (16340523 ~ 16346089) to Ensembl
Sequene Features : Isoforms 3, Variants 28, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of heart contraction
.response to unfolded protein
.protein C-terminus binding .actin cytoskeleton
.Cajal body
.mitochondrion
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 28 1
2014-09-19protein level
3 21 1
2014-05-27protein level
3 21 1
2014-02-25protein level
3 21 1
2013-12-09protein level
3 16 1
2013-11-01protein level
3 16 1
2013-09-12protein level
3 16 1
2013-08-17protein level
3 16 1
2013-07-15protein level
3 14 1
2013-06-11protein level
3 14 1
2013-02-12protein level
3 7 0
2012-12-20protein level
3 7 0
2012-10-30protein level
3 9 0
2012-10-07protein level
3 9 0
2012-08-24protein level
3 8 0
2012-07-28protein level
3 8 0
2012-06-08protein level
3 8 0
2012-05-07protein level
3 8 0
2012-04-10protein level
3 8 0
2012-01-13protein level
3 3 0
2011-12-20protein level
3 3 0
2011-11-11protein level
3 3 0
2011-08-23protein level
3 3 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9UBY9-1
1 8 0 18598.9814
NX_Q9UBY9-2
1 8 0 19076.2136
NX_Q9UBY9-3
1 2 0 7339.3678
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-739361,EBI-533224 TCF4  
  .protein-DNA complex assembly
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 3 more...
.E-box binding
.protein heterodimerization activity
.bHLH transcription factor binding
  + 9 more...
.transcription factor complex
.nucleus
2 EBI-739361,EBI-9641086 FLNA  
  .positive regulation of integrin-mediated signaling pathway
.positive regulation of substrate adhesion-dependent cell spreading
.mitotic spindle assembly
  + 24 more...
.actin filament binding
.Rac GTPase binding
.poly(A) RNA binding
  + 8 more...
.apical dendrite
.extracellular exosome
.perinuclear region of cytoplasm
  + 15 more...
3 EBI-739361,EBI-740098 TRIM23  
  .positive regulation of catalytic activity
.protein ubiquitination
.viral process
.small GTPase mediated signal transduction
.identical protein binding
.GDP binding
.ligase activity
  + 5 more...
.extracellular exosome
.lysosomal membrane
.nucleus
.Golgi membrane
4 EBI-739361,EBI-307352 REL  
  .negative regulation of neuron death
.positive regulation of transcription from RNA polymerase II promoter
.innate immune response
  + 10 more...
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II distal enhancer sequence-specific DNA binding
.I-kappaB/NF-kappaB complex
.cytosol
.transcription factor complex
  + 2 more...
5 EBI-739361,EBI-348469 SF3B4  
  .positive regulation of mRNA splicing, via spliceosome
.gene expression
.RNA splicing
  + 3 more...
.poly(A) RNA binding
.nucleotide binding
.U12-type spliceosomal complex
.spliceosomal complex
.nucleoplasm
6 EBI-739361,EBI-6872807 SYCE1  
  .cell division
.synaptonemal complex assembly
.N/A .central element
7 EBI-739361,EBI-742887 CEP76  
  .regulation of centriole replication
.organelle organization
.mitotic cell cycle
.G2/M transition of mitotic cell cycle
.N/A .protein complex
.cytosol
.centriole
.centrosome
8 EBI-739361,EBI-3957793 PRDM14  
  .homeostasis of number of cells within a tissue
.regulation of DNA methylation
.negative regulation of fibroblast growth factor receptor signaling pathway
  + 11 more...
.metal ion binding
.methyltransferase activity
.DNA binding
.nucleoplasm
9 EBI-739361,EBI-742388 PLEKHF2  
  .protein transport .metal ion binding .early endosome membrane
.transport vesicle
.endoplasmic reticulum
10 EBI-739361,EBI-739074 HSPB8  
  .N/A .identical protein binding .Golgi apparatus
.cytoplasm
.nucleoplasm
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue388
adrenal gland212
bladder66
bone97
bone marrow20
brain19
cervix41
connective tissue248
esophagus99
eye28
heart2859
intestine68
kidney37
liver19
lung29
mammary gland33
mouth241
muscle573
nerve128
ovary19
pancreas4
parathyroid291
placenta49
prostate142
skin47
stomach10
testis59
thyroid107
trachea57
uterus236
vascular19
Health State
TissuesTPM*
normal144
adrenal tumor158
chondrosarcoma36
gastrointestinal tumor8
germ cell tumor3
head and neck tumor7
leukemia10
non-neoplasia217
pancreatic tumor9
soft tissue/muscle tissue tumor199
Developmental Stage
TissuesTPM*
adult61
fetus80
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue230.4
adrenal gland26.8
appendix29
cerebral cortex1.3
colon23.8
duodenum5.8
esophagus46.4
gallbladder25.2
heart muscle1263
kidney12.2
lung8.3
lymph node1.4
ovary15.4
pancreas4.8
placenta7.8
prostate43.9
salivary gland7.3
skin2.2
small intestine7.3
spleen3.4
stomach3.5
testis9
thyroid gland5.3
urinary bladder55.1
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*610692, gene) Heat-shock 27-kd protein 7; HSPB7OMIM


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