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> Protein (NX_Q9UDY8)
Protein (NX_Q9UDY8)
Protein
Gene SymbolMALT1 to neXtProt (NX_Q9UDY8)
DescriptionMucosa-associated lymphoid tissue lymphoma translocation protein 1
Chromosome18
Location18q21.32 (56338618 ~ 56417371) to Ensembl
Sequene Features : Isoforms 2, Variants 70, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.protein oligomerization
.nuclear export
.positive regulation of NF-kappaB transcription factor activity
  + 20 more...
.protein self-association
.peptidase activity
.signal transducer activity
  + 2 more...
.perinuclear region of cytoplasm
.protein complex
.CBM complex
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 70 4
2014-09-19protein level
2 52 4
2014-05-27protein level
2 52 4
2014-02-25protein level
2 51 4
2013-12-09protein level
2 43 4
2013-11-01protein level
2 41 4
2013-09-12protein level
2 41 3
2013-08-17protein level
2 41 3
2013-07-15protein level
2 27 3
2013-06-11protein level
2 27 3
2013-02-12protein level
2 21 6
2012-12-20protein level
2 21 6
2012-10-30protein level
2 20 6
2012-10-07protein level
2 20 3
2012-08-24protein level
2 18 3
2012-07-28protein level
2 18 3
2012-06-08protein level
2 21 3
2012-05-07protein level
2 12 3
2012-04-10protein level
2 12 3
2012-01-13protein level
2 10 3
2011-12-20protein level
2 10 3
2011-11-11protein level
2 10 3
2011-08-23protein level
2 10 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9UDY8-1
1 37 0 92212.867
NX_Q9UDY8-2
1 37 0 91022.3828
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1047372,EBI-958922 BCL10  
  .positive regulation of extrinsic apoptotic signaling pathway
.cellular response to mechanical stimulus
.T cell apoptotic process
  + 29 more...
.NF-kappaB binding
.protein self-association
.protein kinase B binding
  + 9 more...
.perinuclear region of cytoplasm
.membrane raft
.protein complex
  + 8 more...
2 EBI-1047372,EBI-3390054 UBC  
  .programmed necrotic cell death
.apoptotic signaling pathway
.energy homeostasis
  + 90 more...
.poly(A) RNA binding
.protease binding
.extracellular exosome
.endocytic vesicle membrane
.endosome membrane
  + 3 more...
3 EBI-1047372,EBI-307104 SQSTM1  
  .activation of mitophagy in response to mitochondrial depolarization
.apoptotic signaling pathway
.protein heterooligomerization
  + 20 more...
.ubiquitin binding
.identical protein binding
.SH2 domain binding
  + 5 more...
.extracellular exosome
.cytoplasmic vesicle
.PML body
  + 11 more...
4 EBI-1047372,EBI-78060 CASP8  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
  + 55 more...
.cysteine-type endopeptidase activity involved in apoptotic signaling pathway
.cysteine-type endopeptidase activity involved in apoptotic process
.scaffold protein binding
  + 5 more...
.ripoptosome
.membrane raft
.cell body
  + 11 more...
5 EBI-1047372,EBI-359276 TRAF6  
  .positive regulation of transcription regulatory region DNA binding
.apoptotic signaling pathway
.cellular response to lipopolysaccharide
  + 61 more...
.protein N-terminus binding
.protein kinase B binding
.histone deacetylase binding
  + 10 more...
.perinuclear region of cytoplasm
.protein complex
.CD40 receptor complex
  + 10 more...
6 EBI-1047372,EBI-81279 IKBKG  
  .negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
.negative regulation of neuron death
.nucleotide-binding oligomerization domain containing signaling pathway
  + 35 more...
.linear polyubiquitin binding
.K63-linked polyubiquitin binding
.protein heterodimerization activity
  + 5 more...
.mitotic spindle
.IkappaB kinase complex
.cytosol
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood49
bone13
brain4
connective tissue20
embryonic tissue28
eye14
intestine17
kidney33
liver43
lung5
lymph node100
mammary gland33
mouth15
muscle9
ovary9
pancreas23
parathyroid48
placenta10
prostate31
stomach10
testis20
thymus25
tonsil58
trachea19
uterus4
vascular38
Health State
TissuesTPM*
normal18
bladder carcinoma113
breast (mammary gland) tumor42
chondrosarcoma36
colorectal tumor8
germ cell tumor18
head and neck tumor7
kidney tumor14
leukemia31
liver tumor41
non-neoplasia10
ovarian tumor13
pancreatic tumor28
primitive neuroectodermal tumor of the CNS15
prostate cancer38
retinoblastoma21
uterine tumor11
Developmental Stage
TissuesTPM*
adult20
embryoid body42
blastocyst16
fetus10
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue7.4
adrenal gland5.4
appendix21.9
bone marrow8.8
cerebral cortex4
colon9.1
duodenum8.8
esophagus15.5
gallbladder12.9
heart muscle5.9
kidney9.2
liver8.5
lung8.6
lymph node33.8
ovary8.9
pancreas3
placenta6.8
prostate21.8
salivary gland7.4
skin16.2
small intestine10.3
spleen16
stomach6.9
testis16.1
thyroid gland8.9
urinary bladder13.4
Tissues
TissuesExpression level
appendixLow
bone marrowLow
bronchusLow
fallopian tubeLow
lymph nodeHigh
nasopharynxLow
testisLow
tonsilHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604860, gene) Mucosa-associated lymphoid tissue lymphoma translocation gene 1; MALT1OMIM
2mucosa-associated lymphoid tissue lymphomaCGP


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