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> Protein (NX_Q9UER7)
Protein (NX_Q9UER7)
Protein
Gene SymbolDAXX to neXtProt (NX_Q9UER7)
DescriptionDeath domain-associated protein 6
Chromosome6
Location6p21.32 (33286335 ~ 33297046) to Ensembl
Sequene Features : Isoforms 3, Variants 91, PTMs 20 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of apoptotic signaling pathway
.positive regulation of neuron death
.negative regulation of transcription, DNA-templated
  + 13 more...
.androgen receptor binding
.protein N-terminus binding
.protein homodimerization activity
  + 10 more...
.SWI/SNF superfamily-type complex
.PML body
.cytosol
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 91 20
2014-09-19protein level
3 70 20
2014-05-27protein level
3 69 20
2014-02-25protein level
3 17 20
2013-12-09protein level
3 5 20
2013-11-01protein level
3 5 20
2013-09-12protein level
3 5 20
2013-08-17protein level
3 5 20
2013-07-15protein level
3 5 16
2013-06-11protein level
3 5 16
2013-02-12protein level
2 5 31
2012-12-20protein level
2 5 31
2012-10-30protein level
2 6 31
2012-10-07protein level
2 6 18
2012-08-24protein level
2 6 18
2012-07-28protein level
2 6 16
2012-06-08protein level
2 12 16
2012-05-07protein level
2 12 16
2012-04-10protein level
2 12 16
2012-01-13protein level
2 12 16
2011-12-20protein level
2 12 16
2011-11-11protein level
2 12 15
2011-08-23protein level
2 12 15
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9UER7-1
0 24 0 81322.6888
NX_Q9UER7-2
1 21 0 78285.3472
NX_Q9UER7-3
0 21 0 73544.0738
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-77321,EBI-743549 SPOP  
  .positive regulation of type B pancreatic cell apoptotic process
.positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
.proteasome-mediated ubiquitin-dependent protein catabolic process
  + 2 more...
.ubiquitin protein ligase binding .Cul3-RING ubiquitin ligase complex
.nuclear speck
.nucleoplasm
.nucleus
2 EBI-77321,EBI-1753081 AIRE  
  .positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
.humoral immune response
  + 2 more...
.translation regulator activity
.transcription regulatory region DNA binding
.histone binding
  + 4 more...
.cytoplasm
.nucleus
3 EBI-77321,EBI-713259 FTH1  
  .membrane organization
.transmembrane transport
.negative regulation of fibroblast proliferation
  + 7 more...
.ferric iron binding
.iron ion binding
.ferroxidase activity
.extracellular exosome
.intracellular ferritin complex
.cytosol
.nucleus
4 EBI-77321,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
5 EBI-77321,EBI-352682 HSPB1  
  .positive regulation of endothelial cell chemotaxis
.negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
.platelet aggregation
  + 17 more...
.poly(A) RNA binding
.ubiquitin binding
.identical protein binding
  + 3 more...
.extracellular exosome
.Z disc
.focal adhesion
  + 8 more...
6 EBI-77321,EBI-3390054 UBC  
  .programmed necrotic cell death
.apoptotic signaling pathway
.energy homeostasis
  + 90 more...
.poly(A) RNA binding
.protease binding
.extracellular exosome
.endocytic vesicle membrane
.endosome membrane
  + 3 more...
7 EBI-77321,EBI-608057 AR  
  .negative regulation of extrinsic apoptotic signaling pathway
.regulation of establishment of protein localization to plasma membrane
.protein oligomerization
  + 21 more...
.ATPase binding
.protein dimerization activity
.transcription regulatory region DNA binding
  + 14 more...
.protein complex
.cytosol
.cytoplasm
  + 3 more...
8 EBI-287635,EBI-913224 ETS1  
  .response to interleukin-1
.cellular response to hydrogen peroxide
.angiogenesis involved in wound healing
  + 24 more...
.sequence-specific DNA binding
.transcription factor binding
.sequence-specific DNA binding transcription factor activity
  + 2 more...
.intercellular bridge
.cytoplasm
.transcription factor complex
  + 2 more...
9 EBI-77321,EBI-494743 FAS  
  .positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.necroptotic signaling pathway
  + 39 more...
.identical protein binding
.kinase binding
.transmembrane signaling receptor activity
  + 2 more...
.extracellular exosome
.membrane raft
.CD95 death-inducing signaling complex
  + 8 more...
10 EBI-77321,EBI-295890 PML  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of double-strand break repair
.negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
  + 57 more...
.cobalt ion binding
.protein heterodimerization activity
.protein homodimerization activity
  + 5 more...
.extrinsic component of endoplasmic reticulum membrane
.nuclear membrane
.early endosome membrane
  + 7 more...
11 EBI-77321,EBI-296151 TGFBR2  
  .positive regulation of reactive oxygen species metabolic process
.lens fiber cell apoptotic process
.response to cholesterol
  + 51 more...
.transforming growth factor beta binding
.metal ion binding
.SMAD binding
  + 8 more...
.transforming growth factor beta receptor homodimeric complex
.receptor complex
.integral component of membrane
  + 4 more...
12 EBI-77321,EBI-518675 STAT3  
  .negative regulation of neuron migration
.interleukin-6-mediated signaling pathway
.JAK-STAT cascade involved in growth hormone signaling pathway
  + 35 more...
.protein dimerization activity
.transcription regulatory region DNA binding
.protein phosphatase binding
  + 9 more...
.plasma membrane
.cytosol
.mitochondrial inner membrane
  + 4 more...
13 EBI-77321,EBI-396461 ATRX  
  .negative regulation of telomeric RNA transcription from RNA pol II promoter
.cellular response to hydroxyurea
.seminiferous tubule development
  + 17 more...
.chromo shadow domain binding
.histone binding
.methylated histone binding
  + 7 more...
.SWI/SNF superfamily-type complex
.telomeric heterochromatin
.PML body
  + 3 more...
14 EBI-77321,EBI-80140 SUMO1  
  .protein localization to nuclear pore
.regulation of interferon-gamma-mediated signaling pathway
.interferon-gamma-mediated signaling pathway
  + 13 more...
.poly(A) RNA binding
.ubiquitin protein ligase binding
.SUMO transferase activity
.transcription factor binding
.synapse
.nuclear membrane
.dendrite
  + 8 more...
15 EBI-77321,EBI-80168 UBE2I  
  .positive regulation of SUMO transferase activity
.cell division
.positive regulation of sequence-specific DNA binding transcription factor activity
  + 14 more...
.RING-like zinc finger domain binding
.SUMO conjugating enzyme activity
.poly(A) RNA binding
  + 6 more...
.sumoylated E2 ligase complex
.transferase complex
.synapse
  + 7 more...
16 EBI-77321,EBI-389668 MDM2  
  .negative regulation of signal transduction by p53 class mediator
.cellular response to UV-C
.cellular response to hypoxia
  + 44 more...
.ubiquitin protein ligase activity
.identical protein binding
.ubiquitin protein ligase binding
  + 5 more...
.synapse
.protein complex
.endocytic vesicle membrane
  + 6 more...
17 EBI-77321,EBI-73886 RELA  
  .negative regulation of extrinsic apoptotic signaling pathway
.positive regulation of miRNA metabolic process
.negative regulation of NIK/NF-kappaB signaling
  + 64 more...
.repressing transcription factor binding
.NF-kappaB binding
.protein N-terminus binding
  + 20 more...
.NF-kappaB complex
.I-kappaB/NF-kappaB complex
.cytosol
  + 4 more...
18 EBI-77321,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
19 EBI-77321,EBI-301834 HDAC1  
  .histone H4 deacetylation
.histone H3 deacetylation
.fungiform papilla formation
  + 34 more...
.NAD-dependent histone deacetylase activity (H3-K18 specific)
.repressing transcription factor binding
.NF-kappaB binding
  + 17 more...
.protein complex
.NuRD complex
.Sin3 complex
  + 7 more...
20 EBI-77321,EBI-10175124 FAM9B  
  .spermatid development .N/A .nucleoplasm
21 EBI-77321,EBI-625922 CDKN2A  
  .negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.regulation of protein targeting to mitochondrion
.negative regulation of proteolysis involved in cellular protein catabolic process
  + 33 more...
.MDM2/MDM4 family protein binding
.ubiquitin-protein transferase inhibitor activity
.transcription factor binding
  + 2 more...
.protein complex
.mitochondrion
.nucleolus
  + 2 more...
22 EBI-77321,EBI-301821 HDAC2  
  .negative regulation of intrinsic apoptotic signaling pathway
.regulation of protein deacetylation
.negative regulation of canonical Wnt signaling pathway
  + 44 more...
.NAD-dependent histone deacetylase activity (H3-K18 specific)
.NF-kappaB binding
.NAD-dependent histone deacetylase activity (H4-K16 specific)
  + 14 more...
.protein complex
.ESC/E(Z) complex
.NuRD complex
  + 8 more...
23 EBI-77321,EBI-81215 CREBBP  
  .negative regulation of protein stabilization
.regulation of cellular response to heat
.cellular response to hypoxia
  + 27 more...
.MRF binding
.acetyltransferase activity
.zinc ion binding
  + 14 more...
.nuclear body
.cytoplasm
.transcription factor complex
  + 5 more...
24 EBI-77321,EBI-302474 USP7  
  .regulation of proteasomal protein catabolic process
.regulation of sequence-specific DNA binding transcription factor activity
.proteasome-mediated ubiquitin-dependent protein catabolic process
  + 7 more...
.ubiquitin protein ligase binding
.transcription factor binding
.protein C-terminus binding
  + 3 more...
.PML body
.nuclear body
.cytosol
.nucleus
25 EBI-77321,EBI-740845 PBXIP1  
  .negative regulation of transcription, DNA-templated
.cell differentiation
.multicellular organismal development
.transcription corepressor activity .microtubule
.cytosol
.nucleus
26 EBI-77321,EBI-348259 MCRS1  
  .histone H4-K16 acetylation
.histone H4-K8 acetylation
.histone H4-K5 acetylation
  + 6 more...
.N/A .MLL1 complex
.Ino80 complex
.cell junction
  + 5 more...
27 EBI-77321,EBI-5278764 CDCA7L  
  .positive regulation of cell proliferation
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.N/A .cytoplasm
.nucleolus
.nucleus
28 EBI-77321,EBI-1164361 PARK7  
  .negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway
.positive regulation of androgen receptor activity
  + 69 more...
.glyoxalase (glycolic acid-forming) activity
.ubiquitin-specific protease binding
.cuprous ion binding
  + 24 more...
.extracellular exosome
.membrane raft
.cell body
  + 10 more...
29 EBI-77321,EBI-476263 MAP3K5  
  .cellular response to reactive nitrogen species
.positive regulation of neuron death
.programmed necrotic cell death
  + 18 more...
.protein homodimerization activity
.protein phosphatase binding
.cysteine-type endopeptidase activator activity involved in apoptotic process
  + 4 more...
.IRE1-TRAF2-ASK1 complex
.protein kinase complex
.cytosol
30 EBI-77321,EBI-346882 TSG101  
  .positive regulation of viral budding via host ESCRT complex
.regulation of viral budding via host ESCRT complex
.regulation of extracellular exosome assembly
  + 21 more...
.calcium-dependent protein binding
.virion binding
.ubiquitin binding
  + 4 more...
.extracellular exosome
.late endosome membrane
.endosome membrane
  + 8 more...
31 EBI-77321,EBI-3390132 WHSC1L1  
  .negative regulation of transcription, DNA-templated
.histone methylation
.transcription, DNA-templated
.chromatin organization
.histone methyltransferase activity (H3-K27 specific)
.histone methyltransferase activity (H3-K4 specific)
.histone-lysine N-methyltransferase activity
.zinc ion binding
.chromosome
.nucleoplasm
.nucleus
32 EBI-77321,EBI-751319 CARD9  
  .nucleotide-binding oligomerization domain containing signaling pathway
.defense response to virus
.defense response to Gram-positive bacterium
  + 17 more...
.CARD domain binding
.protein homodimerization activity
.plasma membrane
.cytosol
.cytoplasm
33 EBI-77321,EBI-924724 TCF7L2  
  .negative regulation of extrinsic apoptotic signaling pathway
.negative regulation of type B pancreatic cell apoptotic process
.insulin metabolic process
  + 57 more...
.armadillo repeat domain binding
.gamma-catenin binding
.transcription regulatory region DNA binding
  + 9 more...
.beta-catenin-TCF7L2 complex
.protein-DNA complex
.PML body
  + 5 more...
34 EBI-77321,EBI-367363 RASSF1  
  .negative regulation of cell cycle arrest
.protein stabilization
.positive regulation of protein ubiquitination
  + 3 more...
.protein N-terminus binding
.identical protein binding
.zinc ion binding
.microtubule cytoskeleton
.plasma membrane
.microtubule
  + 4 more...
35 EBI-77321,EBI-2212028 SSX2IP  
  .regulation of cell motility
.centrosome organization
.cilium assembly
  + 3 more...
.N/A .protein complex
.ciliary basal body
.centriolar satellite
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland91
ascites150
bladder133
blood179
bone83
bone marrow123
brain65
cervix41
connective tissue80
embryonic tissue112
esophagus198
eye148
heart67
intestine90
kidney66
liver77
lung146
lymph112
lymph node66
mammary gland125
mouth45
muscle37
ovary98
pancreas56
parathyroid145
pharynx196
placenta42
prostate15
skin113
spleen74
stomach104
testis112
thymus87
thyroid236
tonsil117
trachea38
uterus107
vascular116
Health State
TissuesTPM*
normal75
adrenal tumor237
breast (mammary gland) tumor85
cervical tumor57
chondrosarcoma156
colorectal tumor71
esophageal tumor231
gastrointestinal tumor126
germ cell tumor83
glioma111
head and neck tumor44
kidney tumor101
leukemia169
liver tumor104
lung tumor214
lymphoma110
non-neoplasia10
ovarian tumor118
pancreatic tumor57
primitive neuroectodermal tumor of the CNS204
prostate cancer9
retinoblastoma258
skin tumor95
soft tissue/muscle tissue tumor119
uterine tumor44
Developmental Stage
TissuesTPM*
adult73
embryoid body114
blastocyst162
fetus80
infant127
juvenile359
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue20.4
adrenal gland26.6
appendix37.3
bone marrow15.9
cerebral cortex18.2
colon26.9
duodenum20.3
esophagus20.6
gallbladder21.9
heart muscle13.6
kidney16.8
liver19.3
lung24.3
lymph node54.5
ovary25.7
pancreas11.1
placenta23.4
prostate19.9
salivary gland15.7
skin25.8
small intestine20.2
spleen39.5
stomach25.5
testis43.1
thyroid gland22.1
urinary bladder29.7
Tissues
TissuesExpression level
adrenal glandMedium
appendixHigh
bone marrowMedium
breastMedium
bronchusMedium
cerebellumMedium
cerebral cortexMedium
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Low
endometrium 2Low
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderMedium
heart muscleLow
hippocampusLow
kidneyMedium
lateral ventricleLow
liverLow
lungMedium
lymph nodeHigh
nasopharynxMedium
oral mucosaMedium
ovaryMedium
pancreasMedium
parathyroid glandMedium
placentaMedium
prostateLow
rectumMedium
salivary glandMedium
seminal vesicleMedium
skeletal muscleLow
skin 1Medium
skin 2Medium
small intestineMedium
smooth muscleLow
soft tissue 1Low
soft tissue 2Low
spleenMedium
stomach 1Medium
stomach 2Medium
testisHigh
thyroid glandMedium
tonsilHigh
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603186, gene) Death-associated protein 6; DAXXOMIM
2Pancreatic neuroendocrine tumors. Paediatric GBMCGP


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