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> Protein (NX_Q9UEU0)
Protein (NX_Q9UEU0)
Protein
Gene SymbolVTI1B to neXtProt (NX_Q9UEU0)
DescriptionVesicle transport through interaction with t-SNAREs homolog 1B
Chromosome14
Location14q24.1 (68113792 ~ 68141548) to Ensembl
Sequene Features : Isoforms 2, Variants 35, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of protein localization to plasma membrane
.membrane fusion
.vesicle fusion with Golgi apparatus
  + 8 more...
.chloride channel inhibitor activity
.SNAP receptor activity
.SNARE binding
.recycling endosome
.perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
  + 11 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 35 5
2014-09-19protein level
2 29 5
2014-05-27protein level
2 29 5
2014-02-25protein level
2 29 4
2013-12-09protein level
2 16 4
2013-11-01protein level
2 15 4
2013-09-12protein level
2 15 3
2013-08-17protein level
2 15 3
2013-07-15protein level
2 9 2
2013-06-11protein level
2 9 2
2013-02-12protein level
2 8 6
2012-12-20protein level
2 9 6
2012-10-30protein level
2 13 6
2012-10-07protein level
2 13 4
2012-08-24protein level
2 12 4
2012-07-28protein level
2 12 4
2012-06-08protein level
2 13 4
2012-05-07protein level
2 13 4
2012-04-10protein level
2 13 4
2012-01-13protein level
2 7 4
2011-12-20protein level
2 7 4
2011-11-11protein level
2 7 4
2011-08-23protein level
2 7 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9UEU0-1
4 6 0 26671.8144
NX_Q9UEU0-2
0 6 0 19797.4079
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-723716,EBI-1220572 PTPN5  
  .peptidyl-tyrosine dephosphorylation
.protein dephosphorylation
.protein tyrosine phosphatase activity
.phosphotyrosine binding
.integral component of membrane
.endoplasmic reticulum membrane
2 EBI-723716,EBI-10172290 KRTAP10-7  
  .N/A .identical protein binding .keratin filament
3 EBI-723716,EBI-744942 STX4  
  .positive regulation of protein localization to cell surface
.positive regulation of protein localization to plasma membrane
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
  + 21 more...
.sphingomyelin phosphodiesterase activator activity
.SNAP receptor activity
.SNARE binding
.extracellular exosome
.perinuclear region of cytoplasm
.synapse
  + 19 more...
4 EBI-723716,EBI-10173166 LDLRAD1  
  .N/A .N/A .integral component of membrane
5 EBI-723716,EBI-10262539 TRIM59  
  .negative regulation of viral entry into host cell
.innate immune response
.negative regulation of I-kappaB kinase/NF-kappaB signaling
.zinc ion binding
.ubiquitin-protein transferase activity
.integral component of membrane
.endoplasmic reticulum membrane
.endoplasmic reticulum
6 EBI-723716,EBI-7131783 SYNE4  
  .establishment of epithelial cell apical/basal polarity .N/A .LINC complex
.integral component of nuclear outer membrane
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland91
ascites50
bladder100
blood40
bone83
bone marrow41
brain65
cervix185
connective tissue46
ear62
embryonic tissue84
eye71
heart33
intestine47
kidney99
larynx127
liver58
lung56
lymph203
lymph node66
mammary gland92
mouth15
muscle47
nerve64
ovary49
pancreas60
parathyroid97
pharynx24
pituitary gland60
placenta105
prostate68
salivary gland98
skin85
spleen37
stomach20
testis16
thymus25
thyroid128
trachea96
uterus107
vascular19
Health State
TissuesTPM*
normal61
bladder carcinoma170
breast (mammary gland) tumor96
cervical tumor144
chondrosarcoma96
colorectal tumor8
gastrointestinal tumor25
germ cell tumor45
glioma121
head and neck tumor59
kidney tumor58
leukemia21
liver tumor104
lung tumor116
lymphoma138
non-neoplasia41
ovarian tumor65
pancreatic tumor57
primitive neuroectodermal tumor of the CNS47
prostate cancer67
retinoblastoma64
skin tumor111
soft tissue/muscle tissue tumor135
uterine tumor55
Developmental Stage
TissuesTPM*
adult77
embryoid body128
blastocyst81
fetus32
infant85
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue90.2
adrenal gland46.9
appendix39.6
bone marrow32
cerebral cortex54.8
colon64.6
duodenum43.8
esophagus59.8
gallbladder48.2
heart muscle73.4
kidney66.3
liver39.9
lung35.9
lymph node39.9
ovary32.9
pancreas26.4
placenta48.8
prostate31.7
salivary gland59.3
skin44.1
small intestine41.3
spleen32.6
stomach44.8
testis56
thyroid gland61.7
urinary bladder50.5
Tissues
TissuesExpression level
adrenal glandMedium
appendixHigh
bone marrowMedium
breastMedium
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1High
endometrium 2Medium
epididymisHigh
esophagusMedium
fallopian tubeHigh
gallbladderHigh
heart muscleHigh
hippocampusHigh
kidneyHigh
lateral ventricleHigh
liverMedium
lungHigh
lymph nodeLow
nasopharynxHigh
oral mucosaMedium
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateMedium
rectumHigh
salivary glandHigh
seminal vesicleMedium
skeletal muscleLow
skin 1High
skin 2Medium
small intestineHigh
spleenHigh
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilMedium
urinary bladderHigh
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603207, gene) Vti1, s. cerevisiae, homolog of, b; VTI1BOMIM


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