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> Protein (NX_Q9UFF9)
Protein (NX_Q9UFF9)
Protein
Gene SymbolCNOT8 to neXtProt (NX_Q9UFF9)
DescriptionCCR4-NOT transcription complex subunit 8
Chromosome5
Location5q33.2 (154237113 ~ 154256353) to Ensembl
Sequene Features : Isoforms 3, Variants 24, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.RNA phosphodiester bond hydrolysis, exonucleolytic
.positive regulation of mRNA catabolic process
.exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
  + 9 more...
.metal ion binding
.poly(A)-specific ribonuclease activity
.RNA binding
  + 2 more...
.CCR4-NOT complex
.cytosol
.nucleus
.intracellular
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 24 4
2014-09-19protein level
3 19 4
2014-05-27protein level
1 18 4
2014-02-25protein level
1 18 4
2013-12-09protein level
1 12 4
2013-11-01protein level
1 10 4
2013-09-12protein level
1 10 4
2013-08-17protein level
1 10 4
2013-07-15protein level
1 7 0
2013-06-11protein level
1 7 0
2013-02-12protein level
1 2 0
2012-12-20protein level
1 2 0
2012-10-30protein level
1 3 0
2012-10-07protein level
1 3 0
2012-08-24protein level
1 2 0
2012-07-28protein level
1 2 0
2012-06-08protein level
1 7 0
2012-05-07protein level
1 6 0
2012-04-10protein level
1 6 0
2012-01-13protein level
1 8 0
2011-12-20protein level
1 8 0
2011-11-11protein level
1 8 0
2011-08-23protein level
1 8 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9UFF9-1
1 14 0 33518.4394
NX_Q9UFF9-2
1 9 0 21225.3188
NX_Q9UFF9-3
1 12 0 27397.5699
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-742299,EBI-1222758 CNOT1  
  .regulation of stem cell maintenance
.positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.RNA phosphodiester bond hydrolysis, exonucleolytic
  + 13 more...
.armadillo repeat domain binding
.poly(A) RNA binding
.retinoic acid receptor binding
  + 3 more...
.CCR4-NOT complex
.membrane
.cytosol
  + 4 more...
2 EBI-742299,EBI-743073 CNOT3  
  .regulation of stem cell maintenance
.gene silencing by RNA
.gene expression
  + 6 more...
.N/A .CCR4-NOT complex
.cytosol
.nucleus
.cytoplasmic mRNA processing body
3 EBI-742299,EBI-742279 BTG1  
  .positive regulation of fibroblast apoptotic process
.positive regulation of angiogenesis
.positive regulation of myoblast differentiation
  + 5 more...
.kinase binding
.enzyme binding
.transcription cofactor activity
.cytoplasm
.nucleus
4 EBI-742299,EBI-1047576 BTG2  
  .negative regulation of neural precursor cell proliferation
.positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
.response to electrical stimulus
  + 15 more...
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription .extracellular exosome
5 EBI-742299,EBI-2562000 TOB2  
  .positive regulation of ossification
.negative regulation of osteoclast differentiation
.regulation of gene expression
  + 2 more...
.N/A .cytoplasm
.nucleus
6 EBI-742299,EBI-743033 CNOT2  
  .regulation of stem cell maintenance
.RNA phosphodiester bond hydrolysis, exonucleolytic
.negative regulation of intracellular estrogen receptor signaling pathway
  + 10 more...
.RNA polymerase II transcription corepressor binding
.RNA polymerase II transcription cofactor activity
.CCR4-NOT complex
.membrane
.cytosol
  + 2 more...
7 EBI-742299,EBI-2104530 CNOT6  
  .positive regulation of ligand-dependent nuclear receptor transcription coactivator activity
.RNA phosphodiester bond hydrolysis, exonucleolytic
.nuclear-transcribed mRNA catabolic process, no-go decay
  + 10 more...
.metal ion binding
.poly(A)-specific ribonuclease activity
.exoribonuclease activity
.RNA binding
.CCR4-NOT complex
.membrane
.cytosol
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland151
ascites75
bladder100
blood139
bone83
bone marrow123
brain119
cervix82
connective tissue46
ear62
embryonic tissue70
esophagus99
eye86
heart55
intestine73
kidney94
larynx127
liver34
lung68
lymph112
lymph node211
mammary gland46
mouth60
muscle9
nerve64
ovary49
pancreas79
parathyroid339
placenta52
prostate47
salivary gland49
skin80
spleen149
stomach73
testis59
thymus250
thyroid64
tonsil58
trachea77
umbilical cord72
uterus107
vascular19
Health State
TissuesTPM*
normal88
adrenal tumor158
bladder carcinoma56
breast (mammary gland) tumor53
cervical tumor57
chondrosarcoma108
colorectal tumor44
esophageal tumor115
gastrointestinal tumor84
germ cell tumor64
glioma9
head and neck tumor52
kidney tumor43
leukemia148
liver tumor52
lung tumor9
lymphoma152
non-neoplasia41
ovarian tumor52
pancreatic tumor85
primitive neuroectodermal tumor of the CNS165
prostate cancer19
retinoblastoma43
skin tumor55
soft tissue/muscle tissue tumor63
uterine tumor44
Developmental Stage
TissuesTPM*
adult66
embryoid body14
blastocyst113
neonate257
fetus141
infant212
juvenile179
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue33.2
adrenal gland37.5
appendix39
bone marrow63.7
cerebral cortex25.8
colon39.1
duodenum29.3
esophagus26.2
gallbladder31
heart muscle18.4
kidney24
liver15.9
lung41.2
lymph node54.2
ovary28.4
pancreas10.5
placenta36
prostate26.4
salivary gland20.6
skin23.2
small intestine33
spleen44.3
stomach26.6
testis36.9
thyroid gland36.3
urinary bladder39.9
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603731, gene) Ccr4-not transcription complex, subunit 8; CNOT8OMIM


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