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> Protein (NX_Q9UH03)
Protein (NX_Q9UH03)
Protein
Gene SymbolSEPT3 to neXtProt (NX_Q9UH03)
DescriptionNeuronal-specific septin-3
Chromosome22
Location22q13.2 (42372276 ~ 42394225) to Ensembl
Sequene Features : Isoforms 3, Variants 40, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cell division
.cell cycle
.GTP binding .synapse
.cell junction
.cytoskeleton
.cytoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 40 2
2014-09-19protein level
3 33 2
2014-05-27protein level
3 31 2
2014-02-25protein level
3 31 2
2013-12-09protein level
3 26 2
2013-11-01protein level
3 26 1
2013-09-12protein level
3 26 1
2013-08-17protein level
3 26 1
2013-07-15protein level
3 20 1
2013-06-11protein level
3 20 1
2013-02-12protein level
3 7 2
2012-12-20protein level
3 6 2
2012-10-30protein level
3 7 2
2012-10-07protein level
3 7 1
2012-08-24protein level
3 6 1
2012-07-28protein level
3 6 1
2012-06-08protein level
3 6 1
2012-05-07protein level
3 3 1
2012-04-10protein level
3 3 1
2012-01-13protein level
3 3 1
2011-12-20protein level
3 3 1
2011-11-11protein level
3 3 1
2011-08-23protein level
3 3 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9UH03-1
1 14 0 40677.9322
NX_Q9UH03-2
1 14 0 40074.4795
NX_Q9UH03-3
2 1 0 9054.5849
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-727037,EBI-727004 SDCBP  
  .positive regulation of extracellular exosome assembly
.positive regulation of exosomal secretion
.ephrin receptor signaling pathway
  + 9 more...
.protein N-terminus binding
.protein heterodimerization activity
.syndecan binding
  + 4 more...
.blood microparticle
.extracellular exosome
.melanosome
  + 12 more...
2 EBI-727037,EBI-373337 RNF8  
  .protein K48-linked ubiquitination
.histone H2A K63-linked ubiquitination
.protein K63-linked ubiquitination
  + 16 more...
.protein homodimerization activity
.histone binding
.ubiquitin protein ligase binding
  + 4 more...
.site of double-strand break
.midbody
.nucleolus
  + 3 more...
3 EBI-727037,EBI-456371 CKS1B  
  .cell division
.cell proliferation
.mitotic cell cycle
  + 2 more...
.cyclin-dependent protein serine/threonine kinase regulator activity .nucleoplasm
4 EBI-727037,EBI-745901 SEPT6  
  .viral process
.cytokinesis
.GTP binding .axon terminus
.cleavage furrow
.septin complex
  + 4 more...
5 EBI-727037,EBI-742828 LASP1  
  .positive regulation of signal transduction
.ion transport
.ion transmembrane transporter activity
.zinc ion binding
.SH3/SH2 adaptor activity
.extracellular exosome
.cortical actin cytoskeleton
.focal adhesion
6 EBI-727037,EBI-741158 WDYHV1  
  .cellular protein modification process .protein-N-terminal glutamine amidohydrolase activity .cytosol
.nucleus
7 EBI-727037,EBI-748229 MOB1A  
  .hippo signaling .metal ion binding .extracellular exosome
.cytosol
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
brain175
embryonic tissue42
eye90
kidney23
larynx42
liver4
lung5
mammary gland6
mouth15
muscle28
nerve193
pancreas4
placenta17
skin33
testis32
thyroid21
uterus12
vascular96
Health State
TissuesTPM*
normal66
breast (mammary gland) tumor10
germ cell tumor41
glioma74
head and neck tumor22
kidney tumor58
lung tumor19
non-neoplasia72
pancreatic tumor9
primitive neuroectodermal tumor of the CNS118
retinoblastoma150
skin tumor55
soft tissue/muscle tissue tumor15
uterine tumor11
Developmental Stage
TissuesTPM*
adult37
embryoid body14
blastocyst65
fetus145
infant212
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adrenal gland5.3
cerebral cortex128.6
placenta6.7
prostate1.1
skin1.5
testis1.8
thyroid gland1
Tissues
TissuesExpression level
cerebellumHigh
cerebral cortexMedium
hippocampusMedium
lateral ventricleMedium
pancreasMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*608314, gene) Septin 3; SEPT3OMIM


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