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> Protein (NX_Q9UHB7)
Protein (NX_Q9UHB7)
Protein
Gene SymbolAFF4 to neXtProt (NX_Q9UHB7)
DescriptionAF4/FMR2 family member 4
Chromosome5
Location5q31.1 (132211071 ~ 132299326) to Ensembl
Sequene Features : Isoforms 3, Variants 130, PTMs 27 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.spermatid development
.transcription from RNA polymerase II promoter
.sequence-specific DNA binding transcription factor activity .transcriptionally active chromatin
.transcription elongation factor complex
.mitochondrion
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 130 27
2014-09-19protein level
3 99 27
2014-05-27protein level
3 99 27
2014-02-25protein level
3 99 26
2013-12-09protein level
3 82 26
2013-11-01protein level
3 80 25
2013-09-12protein level
3 80 25
2013-08-17protein level
3 80 25
2013-07-15protein level
3 49 24
2013-06-11protein level
3 49 24
2013-02-12protein level
3 23 71
2012-12-20protein level
3 24 71
2012-10-30protein level
3 28 71
2012-10-07protein level
3 28 34
2012-08-24protein level
3 17 34
2012-07-28protein level
3 17 34
2012-06-08protein level
3 22 34
2012-05-07protein level
3 22 34
2012-04-10protein level
3 22 34
2012-01-13protein level
3 15 34
2011-12-20protein level
3 15 34
2011-11-11protein level
3 15 33
2011-08-23protein level
3 15 33
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9UHB7-1
13 38 0 127381.3937
NX_Q9UHB7-2
1 38 0 98145.5026
NX_Q9UHB7-3
0 18 0 38798.7284
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-395282,EBI-2479671 CCNT1  
  .negative regulation of mRNA polyadenylation
.cell division
.positive regulation of viral transcription
  + 11 more...
.transcription regulatory region DNA binding
.snRNA binding
.chromatin binding
.DNA binding
.positive transcription elongation factor complex b
.nucleoplasm
.nucleus
2 EBI-395282,EBI-716132 MLLT3  
  .positive regulation of Wnt signaling pathway, planar cell polarity pathway
.negative regulation of canonical Wnt signaling pathway
.anterior/posterior pattern specification
  + 3 more...
.N/A .extracellular exosome
.transcription elongation factor complex
.nucleus
3 EBI-395282,EBI-432924 AP2B1  
  .clathrin-mediated endocytosis
.regulation of defense response to virus by virus
.ephrin receptor signaling pathway
  + 8 more...
.clathrin binding
.protein transporter activity
.signal sequence binding
.intracellular membrane-bounded organelle
.clathrin-coated endocytic vesicle membrane
.endocytic vesicle membrane
  + 4 more...
4 EBI-395282,EBI-1384215 MLLT1  
  .negative regulation of protein kinase activity
.transcription from RNA polymerase II promoter
.regulation of transcription, DNA-templated
.DNA binding .transcription elongation factor complex
.cytoplasm
.nucleolus
  + 2 more...
5 EBI-395282,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
6 EBI-10261324,EBI-355744 TRAF2  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.negative regulation of neuron death
  + 35 more...
.sphingolipid binding
.identical protein binding
.thioesterase binding
  + 10 more...
.IRE1-TRAF2-ASK1 complex
.TRAF2-GSTP1 complex
.membrane raft
  + 7 more...
7 EBI-395282,EBI-742948 MTUS2  
  .N/A .protein homodimerization activity
.microtubule binding
.microtubule
.cytoplasm
.nucleus
8 EBI-10261324,EBI-747107 SIAH1  
  .positive regulation of intrinsic apoptotic signaling pathway
.neuron apoptotic process
.proteasome-mediated ubiquitin-dependent protein catabolic process
  + 11 more...
.ubiquitin protein ligase activity
.identical protein binding
.ligase activity
  + 3 more...
.beta-catenin destruction complex
.plasma membrane
.cytosol
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland121
ascites100
bladder33
blood40
bone97
bone marrow61
brain53
cervix20
connective tissue40
ear186
embryonic tissue103
esophagus49
eye76
heart78
intestine38
kidney56
larynx85
liver73
lung59
lymph45
lymph node55
mammary gland204
mouth75
muscle56
nerve128
ovary19
pancreas14
pharynx24
pituitary gland121
placenta42
prostate100
skin18
spleen74
stomach62
testis80
thymus138
thyroid42
tonsil58
trachea38
uterus133
vascular116
Health State
TissuesTPM*
normal76
adrenal tumor237
breast (mammary gland) tumor118
cervical tumor28
chondrosarcoma12
colorectal tumor17
esophageal tumor57
gastrointestinal tumor75
germ cell tumor26
head and neck tumor74
kidney tumor43
leukemia42
liver tumor62
lung tumor19
lymphoma27
non-neoplasia93
ovarian tumor13
pancreatic tumor9
Developmental Stage
TissuesTPM*
adult79
embryoid body200
blastocyst97
fetus87
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue18
adrenal gland29
appendix17.6
bone marrow27.2
cerebral cortex20.8
colon19.3
duodenum13.6
esophagus26.9
gallbladder27.9
heart muscle13
kidney22.3
liver17.1
lung16.6
lymph node14.8
ovary27.4
pancreas12
placenta18.5
prostate21.5
salivary gland13.6
skin13.7
small intestine14
spleen15.1
stomach23
testis26.3
thyroid gland32.5
urinary bladder20.1
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604417, gene) Af4/fmr2 family, member 4; AFF4OMIM


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