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> Protein (NX_Q9UHD2)
Protein (NX_Q9UHD2)
Protein
Gene SymbolTBK1 to neXtProt (NX_Q9UHD2)
DescriptionSerine/threonine-protein kinase TBK1
Chromosome12
Location12q14.2 (64845660 ~ 64895888) to Ensembl
Sequene Features : Isoforms 1, Variants 79, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.defense response to virus
.defense response to Gram-positive bacterium
.positive regulation of transcription from RNA polymerase II promoter
  + 20 more...
.phosphoprotein binding
.ATP binding
.protein serine/threonine kinase activity
  + 2 more...
.endosome membrane
.cytosol
.cytoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 79 5
2014-09-19protein level
1 63 5
2014-05-27protein level
1 63 5
2014-02-25protein level
1 61 5
2013-12-09protein level
1 51 3
2013-11-01protein level
1 49 3
2013-09-12protein level
1 49 3
2013-08-17protein level
1 47 3
2013-07-15protein level
1 29 2
2013-06-11protein level
1 29 2
2013-02-12protein level
1 20 5
2012-12-20protein level
1 19 5
2012-10-30protein level
1 23 5
2012-10-07protein level
1 23 5
2012-08-24protein level
1 23 5
2012-07-28protein level
1 22 5
2012-06-08protein level
1 26 5
2012-05-07protein level
1 18 4
2012-04-10protein level
1 18 4
2012-01-13protein level
1 14 4
2011-12-20protein level
1 14 4
2011-11-11protein level
1 14 4
2011-08-23protein level
1 14 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9UHD2-1
36 0 2 83588.5802
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-356402,EBI-359969 TBKBP1  
  .innate immune response .N/A .N/A
2 EBI-356402,EBI-352572 HSP90AB1  
  .regulation of cellular response to heat
.fibril organization
.cellular response to interleukin-4
  + 14 more...
.poly(A) RNA binding
.TPR domain binding
.nitric-oxide synthase regulator activity
  + 4 more...
.extracellular exosome
.melanosome
.membrane
  + 4 more...
3 EBI-356402,EBI-359793 TXLNA  
  .activation of mitophagy in response to mitochondrial depolarization
.B cell activation
.cell proliferation
.exocytosis
.high molecular weight B cell growth factor receptor binding
.cytokine activity
.membrane
.cytoplasm
.extracellular region
4 EBI-356402,EBI-1186478 STAT6  
  .cellular response to reactive nitrogen species
.cellular response to hydrogen peroxide
.mammary gland morphogenesis
  + 13 more...
.identical protein binding
.protein phosphatase binding
.signal transducer activity
  + 2 more...
.membrane raft
.cytosol
.cytoplasm
  + 2 more...
5 EBI-356402,EBI-355744 TRAF2  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.negative regulation of neuron death
  + 35 more...
.sphingolipid binding
.identical protein binding
.thioesterase binding
  + 10 more...
.IRE1-TRAF2-ASK1 complex
.TRAF2-GSTP1 complex
.membrane raft
  + 7 more...
6 EBI-356402,EBI-739580 CALCOCO2  
  .response to interferon-gamma
.viral process
.protein homodimerization activity .perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.membrane
  + 4 more...
7 EBI-356402,EBI-307369 IKBKE  
  .innate immune response
.positive regulation of I-kappaB kinase/NF-kappaB signaling
.NIK/NF-kappaB signaling
  + 9 more...
.IkappaB kinase activity
.ATP binding
.NF-kappaB-inducing kinase activity
.mitochondrial membrane
.PML body
.endosome membrane
  + 4 more...
8 EBI-356402,EBI-2650369 IRF3  
  .programmed necrotic cell death
.macrophage apoptotic process
.cellular response to dsRNA
  + 28 more...
.transcription regulatory region DNA binding
.protein homodimerization activity
.identical protein binding
  + 3 more...
.cytosol
.cytoplasm
.nucleoplasm
.nucleus
9 EBI-356402,EBI-689124 CDC42BPG  
  .intracellular signal transduction
.actin cytoskeleton reorganization
.protein phosphorylation
.ATP binding
.protein serine/threonine kinase activity
.magnesium ion binding
.cell leading edge
.cytoplasm
10 EBI-356402,EBI-727146 ATG9A  
  .innate immune response
.late nucleophagy
.piecemeal microautophagy of nucleus
  + 5 more...
.N/A .recycling endosome
.late endosome membrane
.cytoplasmic vesicle
  + 8 more...
11 EBI-356402,EBI-2800345 TMEM173  
  .cellular response to exogenous dsRNA
.defense response to virus
.positive regulation of transcription from RNA polymerase II promoter
  + 11 more...
.cyclic-GMP-AMP binding
.protein homodimerization activity
.identical protein binding
  + 3 more...
.perinuclear region of cytoplasm
.cytoplasmic vesicle membrane
.integral component of membrane
  + 5 more...
12 EBI-356402,EBI-2129148 MIB1  
  .positive regulation of endocytosis
.negative regulation of neuron differentiation
.protein ubiquitination
  + 7 more...
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.cytoplasmic vesicle
.postsynaptic density
.plasma membrane
  + 3 more...
13 EBI-356402,EBI-356349 TANK  
  .innate immune response
.TRIF-dependent toll-like receptor signaling pathway
.toll-like receptor 4 signaling pathway
  + 5 more...
.metal ion binding
.ubiquitin protein ligase binding
.cytosol
.cytoplasm
14 EBI-356402,EBI-968267 IRF7  
  .negative regulation of macrophage apoptotic process
.positive regulation of type I interferon-mediated signaling pathway
.type I interferon signaling pathway
  + 30 more...
.DNA binding
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity
.RNA polymerase II core promoter sequence-specific DNA binding
.endosome membrane
.cytosol
.cytoplasm
  + 2 more...
15 EBI-356402,EBI-2130249 MIB2  
  .positive regulation of I-kappaB kinase/NF-kappaB signaling
.protein ubiquitination
.Notch signaling pathway
.ligase activity
.zinc ion binding
.signal transducer activity
.ubiquitin-protein transferase activity
.early endosome
.cytoplasm
.ubiquitin ligase complex
16 EBI-356402,EBI-748974 OPTN  
  .Golgi ribbon formation
.defense response to Gram-negative bacterium
.negative regulation of I-kappaB kinase/NF-kappaB signaling
  + 10 more...
.K63-linked polyubiquitin binding
.identical protein binding
.polyubiquitin binding
  + 2 more...
.recycling endosome
.perinuclear region of cytoplasm
.cytoplasmic membrane-bounded vesicle
  + 8 more...
17 EBI-356402,EBI-359973 AZI2  
  .dendritic cell differentiation
.dendritic cell proliferation
.T cell activation
  + 6 more...
.N/A .cytoplasm
18 EBI-356402,EBI-2556166 MTPAP  
  .histone mRNA catabolic process
.mRNA polyadenylation
.transcription, DNA-templated
.poly(A) RNA binding
.protein homodimerization activity
.identical protein binding
  + 5 more...
.intracellular membrane-bounded organelle
.mitochondrion
19 EBI-356402,EBI-528269 AGO2  
  .positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.mRNA cleavage involved in gene silencing by siRNA
.RNA phosphodiester bond hydrolysis, endonucleolytic
  + 25 more...
.endoribonuclease activity, cleaving miRNA-paired mRNA
.pre-miRNA binding
.endoribonuclease activity, cleaving siRNA-paired mRNA
  + 12 more...
.RISC-loading complex
.micro-ribonucleoprotein complex
.ribonucleoprotein complex
  + 9 more...
20 EBI-356402,EBI-81279 IKBKG  
  .negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
.negative regulation of neuron death
.nucleotide-binding oligomerization domain containing signaling pathway
  + 35 more...
.linear polyubiquitin binding
.K63-linked polyubiquitin binding
.protein heterodimerization activity
  + 5 more...
.mitotic spindle
.IkappaB kinase complex
.cytosol
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites50
bladder66
blood24
bone27
bone marrow41
brain32
cervix20
connective tissue20
ear124
embryonic tissue56
esophagus99
eye4
heart44
intestine38
kidney90
liver9
lung23
lymph45
lymph node122
mammary gland26
mouth15
muscle18
nerve128
ovary19
pancreas23
parathyroid48
pharynx24
pituitary gland60
placenta35
prostate47
skin56
spleen18
stomach10
testis82
thymus25
trachea19
uterus30
Health State
TissuesTPM*
normal40
bladder carcinoma113
breast (mammary gland) tumor32
cervical tumor28
chondrosarcoma36
colorectal tumor35
esophageal tumor115
gastrointestinal tumor25
germ cell tumor37
glioma9
head and neck tumor7
kidney tumor58
leukemia10
liver tumor10
lymphoma83
non-neoplasia41
ovarian tumor26
pancreatic tumor19
prostate cancer9
retinoblastoma21
skin tumor31
soft tissue/muscle tissue tumor23
uterine tumor33
Developmental Stage
TissuesTPM*
adult30
embryoid body42
blastocyst65
neonate64
fetus32
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue11.4
adrenal gland17.7
appendix17.7
bone marrow20
cerebral cortex13.5
colon12.6
duodenum16.1
esophagus14.8
gallbladder16.1
heart muscle8.1
kidney12
liver9.8
lung14.2
lymph node19.4
ovary11.3
pancreas4.1
placenta20.2
prostate14.2
salivary gland8.1
skin10.1
small intestine14.1
spleen17.2
stomach13.6
testis28
thyroid gland12.3
urinary bladder19.4
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(-177700, phenotype) PseudoglaucomaOMIM
2(*604834, gene) Tank-binding kinase 1; TBK1OMIM


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