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> Protein (NX_Q9UHG0)
Protein (NX_Q9UHG0)
Protein
Gene SymbolDCDC2 to neXtProt (NX_Q9UHG0)
DescriptionDoublecortin domain-containing protein 2
Chromosome6
Location6p22.3 (24171984 ~ 24358280) to Ensembl
Sequene Features : Isoforms 2, Variants 70, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.dendrite morphogenesis
.positive regulation of smoothened signaling pathway
.intracellular signal transduction
  + 4 more...
.N/A .primary cilium
.axoneme
.cytoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 70 1
2014-09-19protein level
2 50 1
2014-05-27protein level
2 50 1
2014-02-25protein level
2 49 1
2013-12-09protein level
2 39 1
2013-11-01protein level
2 38 1
2013-09-12protein level
2 38 1
2013-08-17protein level
2 38 1
2013-07-15protein level
2 31 1
2013-06-11protein level
2 31 1
2013-02-12protein level
2 16 0
2012-12-20protein level
2 17 0
2012-10-30protein level
2 23 0
2012-10-07protein level
2 23 0
2012-08-24protein level
2 16 0
2012-07-28protein level
2 16 0
2012-06-08protein level
2 19 0
2012-05-07protein level
2 19 0
2012-04-10protein level
2 19 0
2012-01-13protein level
2 10 0
2011-12-20protein level
2 10 0
2011-11-11protein level
2 10 0
2011-08-23protein level
2 10 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9UHG0-1
14 6 0 52801.7927
NX_Q9UHG0-2
2 6 0 25566.054
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-10303987,EBI-740897 NIF3L1  
  .negative regulation of nucleic acid-templated transcription
.positive regulation of transcription, DNA-templated
.neuron differentiation
.identical protein binding
.transcription factor binding
.mitochondrion
.cytoplasm
.nucleus
2 EBI-10303987,EBI-995714 MRFAP1  
  .N/A .N/A .perinuclear region of cytoplasm
.nucleoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
brain1
eye4
heart22
intestine8
kidney23
liver58
lung5
muscle9
pituitary gland60
spleen18
stomach10
testis11
uterus30
Health State
TissuesTPM*
normal9
gastrointestinal tumor16
liver tumor62
lung tumor9
primitive neuroectodermal tumor of the CNS7
uterine tumor55
Developmental Stage
TissuesTPM*
adult8
fetus19
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adrenal gland1.4
cerebral cortex1.2
gallbladder11.5
kidney22.4
liver1.7
lung4.9
pancreas13.4
prostate1
stomach1.7
testis3.9
thyroid gland21.9
Tissues
TissuesExpression level
adrenal glandLow
appendixLow
bronchusMedium
cerebral cortexLow
cervix, uterineMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeHigh
gallbladderMedium
kidneyHigh
liverHigh
nasopharynxMedium
oral mucosaLow
pancreasHigh
prostateLow
seminal vesicleMedium
skin 1Low
skin 2Low
soft tissue 1Low
soft tissue 2Low
testisLow
thyroid glandLow
tonsilLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(%600202, phenotype) Dyslexia, susceptibility to, 2; DYX2OMIM
2(*605755, gene) Doublecortin domain-containing protein 2; DCDC2OMIM


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