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> Protein (NX_Q9UHI7)
Protein (NX_Q9UHI7)
Protein
Gene SymbolSLC23A1 to neXtProt (NX_Q9UHI7)
DescriptionSolute carrier family 23 member 1
Chromosome5
Location5q31.2 (138702885 ~ 138720242) to Ensembl
Sequene Features : Isoforms 3, Variants 70, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.transepithelial L-ascorbic acid transport
.dehydroascorbic acid transport
.small molecule metabolic process
  + 12 more...
.sodium-dependent L-ascorbate transmembrane transporter activity
.dehydroascorbic acid transporter activity
.L-ascorbic acid transporter activity
  + 3 more...
.extracellular exosome
.intracellular organelle
.apical plasma membrane
  + 6 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 70 3
2014-09-19protein level
3 47 3
2014-05-27protein level
3 47 3
2014-02-25protein level
3 47 3
2013-12-09protein level
3 35 3
2013-11-01protein level
3 34 3
2013-09-12protein level
3 34 3
2013-08-17protein level
3 34 3
2013-07-15protein level
3 18 3
2013-06-11protein level
3 18 3
2013-02-12protein level
3 11 9
2012-12-20protein level
3 12 9
2012-10-30protein level
3 17 9
2012-10-07protein level
3 17 4
2012-08-24protein level
3 14 4
2012-07-28protein level
3 14 4
2012-06-08protein level
3 29 4
2012-05-07protein level
3 29 4
2012-04-10protein level
3 29 4
2012-01-13protein level
3 25 4
2011-12-20protein level
3 25 4
2011-11-11protein level
3 25 4
2011-08-23protein level
3 25 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9UHI7-1
1 19 0 64788.5859
NX_Q9UHI7-2
1 19 0 65194.8175
NX_Q9UHI7-3
1 7 0 28512.1438
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1759386,EBI-2371423 AHCYL1  
  .response to calcium ion
.regulation of anion transport
.S-adenosylmethionine cycle
  + 6 more...
.hydrolase activity .extracellular exosome
.cytosol
.endoplasmic reticulum
2 EBI-1759386,EBI-389883 NCK1  
  .negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.negative regulation of PERK-mediated unfolded protein response
  + 23 more...
.eukaryotic initiation factor eIF2 binding
.receptor tyrosine kinase binding
.protein binding, bridging
  + 5 more...
.vesicle membrane
.cell-cell junction
.plasma membrane
  + 6 more...
3 EBI-1759386,EBI-10172150 KRTAP10-5  
  .N/A .identical protein binding .keratin filament
4 EBI-1759386,EBI-10172290 KRTAP10-7  
  .N/A .identical protein binding .keratin filament
5 EBI-1759386,EBI-10171774 KRTAP10-8  
  .N/A .N/A .keratin filament
6 EBI-1759386,EBI-10172052 KRTAP10-9  
  .N/A .N/A .keratin filament
7 EBI-1759386,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
8 EBI-1759386,EBI-742948 MTUS2  
  .N/A .protein homodimerization activity
.microtubule binding
.microtubule
.cytoplasm
.nucleus
9 EBI-1759386,EBI-10173507 ADAMTSL4  
  .cellular protein metabolic process
.post-translational protein modification
.positive regulation of apoptotic process
  + 4 more...
.metalloendopeptidase activity
.protease binding
.endoplasmic reticulum lumen
.interstitial matrix
10 EBI-1759386,EBI-945833 NOTCH2NL  
  .cell differentiation
.multicellular organismal development
.Notch signaling pathway
.calcium ion binding .cytoplasm
.extracellular region
11 EBI-1759386,EBI-10172511 KRTAP4-2  
  .N/A .N/A .keratin filament
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
blood8
brain8
intestine38
kidney260
liver19
lymph node11
prostate21
spleen18
uterus12
Health State
TissuesTPM*
normal24
colorectal tumor8
liver tumor10
uterine tumor33
Developmental Stage
TissuesTPM*
adult5
neonate32
fetus1
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
colon3
duodenum23.7
gallbladder2.6
kidney40.9
liver11.3
prostate7.5
salivary gland2.2
skin1.2
small intestine56.2
Tissues
TissuesExpression level
bronchusLow
cerebellumMedium
cerebral cortexMedium
colonMedium
fallopian tubeHigh
hippocampusMedium
kidneyHigh
lateral ventricleLow
lungLow
nasopharynxMedium
salivary glandLow
skin 1Low
small intestineHigh
stomach 1Low
stomach 2Medium
thyroid glandLow
tonsilLow
urinary bladderMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603790, gene) Solute carrier family 23 (nucleobase transporter), member 1; SLC23A1OMIM


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