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> Protein (NX_Q9UHX1)
Protein (NX_Q9UHX1)
Protein
Gene SymbolPUF60 to neXtProt (NX_Q9UHX1)
DescriptionPoly(U)-binding-splicing factor PUF60
Chromosome8
Location8q24.3 (144898514 ~ 144912029) to Ensembl
Sequene Features : Isoforms 6, Variants 33, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.RNA splicing
.apoptotic process
.mRNA processing
  + 2 more...
.poly(A) RNA binding
.identical protein binding
.DNA binding
.nucleotide binding
.ribonucleoprotein complex
.Golgi apparatus
.mitochondrion
.nucleoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
6 33 9
2014-09-19protein level
6 23 9
2014-05-27protein level
6 22 9
2014-02-25protein level
6 22 9
2013-12-09protein level
6 20 9
2013-11-01protein level
6 20 9
2013-09-12protein level
6 20 9
2013-08-17protein level
6 20 9
2013-07-15protein level
6 15 8
2013-06-11protein level
6 15 8
2013-02-12protein level
6 3 45
2012-12-20protein level
6 3 45
2012-10-30protein level
6 3 45
2012-10-07protein level
6 3 8
2012-08-24protein level
6 1 8
2012-07-28protein level
6 1 8
2012-06-08protein level
6 3 8
2012-05-07protein level
6 3 8
2012-04-10protein level
6 3 8
2012-01-13protein level
6 6 8
2011-12-20protein level
6 6 8
2011-11-11protein level
6 6 5
2011-08-23protein level
6 6 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9UHX1-1
0 25 0 59837.4536
NX_Q9UHX1-2
0 25 0 58134.6523
NX_Q9UHX1-3
0 23 0 55693.3644
NX_Q9UHX1-4
0 23 0 53990.5631
NX_Q9UHX1-5
0 24 0 57067.0829
NX_Q9UHX1-6
0 24 0 55364.2816
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1053259,EBI-766279 CACNA1A  
  .membrane depolarization during action potential
.calcium ion import
.rhythmic synaptic transmission
  + 37 more...
.metal ion binding
.syntaxin binding
.high voltage-gated calcium channel activity
.voltage-gated calcium channel activity
.neuronal cell body
.cell projection
.dendrite
  + 5 more...
2 EBI-1053259,EBI-727004 SDCBP  
  .positive regulation of extracellular exosome assembly
.positive regulation of exosomal secretion
.ephrin receptor signaling pathway
  + 9 more...
.protein N-terminus binding
.protein heterodimerization activity
.syndecan binding
  + 4 more...
.blood microparticle
.extracellular exosome
.melanosome
  + 12 more...
3 EBI-1053259,EBI-746479 ZG16  
  .protein transport .carbohydrate binding .cytoplasmic membrane-bounded vesicle lumen
.zymogen granule membrane
.extracellular matrix
  + 2 more...
4 EBI-1053259,EBI-395261 CCNC  
  .positive regulation of transcription from RNA polymerase II promoter
.gene expression
.Notch signaling pathway
  + 4 more...
.N/A .mediator complex
.nucleoplasm
5 EBI-1053259,EBI-742339 U2AF2  
  .negative regulation of mRNA splicing, via spliceosome
.positive regulation of RNA splicing
.mRNA 3'-end processing
  + 7 more...
.poly(A) RNA binding
.enzyme binding
.nucleotide binding
.nuclear speck
.spliceosomal complex
.nucleoplasm
6 EBI-1053259,EBI-954531 RAD23B  
  .proteasome-mediated ubiquitin-dependent protein catabolic process
.regulation of proteasomal ubiquitin-dependent protein catabolic process
.spermatogenesis
  + 4 more...
.polyubiquitin binding
.single-stranded DNA binding
.damaged DNA binding
.XPC complex
.cytoplasm
.nucleoplasm
  + 2 more...
7 EBI-1053259,EBI-1051785 SRSF11  
  .mRNA 3'-end processing
.gene expression
.RNA splicing
  + 5 more...
.poly(A) RNA binding
.nucleotide binding
.nucleoplasm
.nucleus
8 EBI-1053259,EBI-946095 PCBP1  
  .gene expression
.RNA splicing
.mRNA splicing, via spliceosome
.poly(A) RNA binding
.RNA binding
.single-stranded DNA binding
.extracellular exosome
.intracellular membrane-bounded organelle
.ribonucleoprotein complex
  + 3 more...
9 EBI-1053259,EBI-2798044 QRICH1  
  .N/A .N/A .nucleoplasm
10 EBI-1053259,EBI-751942 KIAA0907  
  .N/A .RNA binding .N/A
11 EBI-1053259,EBI-747107 SIAH1  
  .positive regulation of intrinsic apoptotic signaling pathway
.neuron apoptotic process
.proteasome-mediated ubiquitin-dependent protein catabolic process
  + 11 more...
.ubiquitin protein ligase activity
.identical protein binding
.ligase activity
  + 3 more...
.beta-catenin destruction complex
.plasma membrane
.cytosol
  + 3 more...
12 EBI-1053259,EBI-747707 LOH12CR1  
  .N/A .N/A .N/A
13 EBI-1053259,EBI-4401082 ARL8A  
  .cell division
.metabolic process
.small GTPase mediated signal transduction
  + 2 more...
.beta-tubulin binding
.alpha-tubulin binding
.GTP binding
.GTPase activity
.extracellular exosome
.spindle midzone
.late endosome membrane
  + 4 more...
14 EBI-1053259,EBI-710402 PPP1R16A  
  .N/A .protein phosphatase type 1 regulator activity .plasma membrane
15 EBI-1053259,EBI-745878 KIAA1683  
  .N/A .N/A .mitochondrion
.nucleus
16 EBI-1053259,EBI-514199 MED28  
  .negative regulation of smooth muscle cell differentiation
.stem cell maintenance
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.N/A .cortical actin cytoskeleton
.mediator complex
.membrane
17 EBI-1053259,EBI-372073 UPF2  
  .organ regeneration
.gene expression
.mRNA export from nucleus
  + 2 more...
.RNA binding .perinuclear region of cytoplasm
.exon-exon junction complex
.cytosol
  + 2 more...
18 EBI-1053259,EBI-751683 SAP30BP  
  .negative regulation of gene expression, epigenetic
.regulation of gene expression, epigenetic
.positive regulation of cell death
  + 4 more...
.N/A .intermediate filament cytoskeleton
.nucleoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue233
adrenal gland91
ascites753
bladder33
blood204
bone111
bone marrow20
brain97
cervix309
connective tissue26
ear62
embryonic tissue319
esophagus49
eye196
heart55
intestine107
kidney151
larynx213
liver107
lung218
lymph293
lymph node211
mammary gland66
muscle159
nerve321
ovary364
pancreas178
parathyroid97
pituitary gland60
placenta176
prostate163
salivary gland148
skin294
spleen37
stomach20
testis59
thymus12
thyroid42
tonsil411
uterus189
Health State
TissuesTPM*
normal109
adrenal tumor79
bladder carcinoma56
breast (mammary gland) tumor64
cervical tumor347
chondrosarcoma60
colorectal tumor168
esophageal tumor57
gastrointestinal tumor430
germ cell tumor125
glioma401
head and neck tumor74
kidney tumor275
leukemia169
liver tumor177
lung tumor535
lymphoma277
non-neoplasia31
ovarian tumor367
pancreatic tumor361
primitive neuroectodermal tumor of the CNS228
prostate cancer240
retinoblastoma279
skin tumor414
soft tissue/muscle tissue tumor271
uterine tumor166
Developmental Stage
TissuesTPM*
adult137
embryoid body285
blastocyst374
fetus105
juvenile251
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue43.5
adrenal gland40.7
appendix45.7
bone marrow53.6
cerebral cortex61.4
colon45.8
duodenum49.5
esophagus53.5
gallbladder42.8
heart muscle48
kidney39.7
liver32.1
lung44.8
lymph node58.5
ovary37.3
pancreas27.9
placenta46.4
prostate47.9
salivary gland43.1
skin60.1
small intestine45.6
spleen47.4
stomach43.4
testis59.4
thyroid gland45.1
urinary bladder47.2
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604819, gene) Poly-u-binding splicing factor, 60-kd; PUF60OMIM


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