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> Protein (NX_Q9UI95)
Protein (NX_Q9UI95)
Protein
Gene SymbolMAD2L2 to neXtProt (NX_Q9UI95)
DescriptionMitotic spindle assembly checkpoint protein MAD2B
Chromosome1
Location1p36.22 (11734537 ~ 11751707) to Ensembl
Sequene Features : Isoforms 1, Variants 11, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of transcription regulatory region DNA binding
.negative regulation of cell-cell adhesion mediated by cadherin
.negative regulation of canonical Wnt signaling pathway
  + 19 more...
.JUN kinase binding
.RNA polymerase II activating transcription factor binding
.zeta DNA polymerase complex
.spindle
.cytoplasm
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 11 2
2014-09-19protein level
1 10 2
2014-05-27protein level
1 10 2
2014-02-25protein level
1 10 2
2013-12-09protein level
1 8 2
2013-11-01protein level
1 8 1
2013-09-12protein level
1 8 1
2013-08-17protein level
1 8 1
2013-07-15protein level
1 3 0
2013-06-11protein level
1 3 0
2013-02-12protein level
1 2 0
2012-12-20protein level
1 2 0
2012-10-30protein level
1 3 0
2012-10-07protein level
1 3 0
2012-08-24protein level
1 2 0
2012-07-28protein level
1 2 0
2012-06-08protein level
1 11 0
2012-05-07protein level
1 11 0
2012-04-10protein level
1 11 0
2012-01-13protein level
1 10 0
2011-12-20protein level
1 10 0
2011-11-11protein level
1 10 0
2011-08-23protein level
1 10 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9UI95-1
9 0 0 24318.6945
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-77889,EBI-10321817 SFI1  
  .negative regulation of phosphatase activity
.organelle organization
.mitotic cell cycle
.G2/M transition of mitotic cell cycle
.phosphatase binding .cytosol
.centriole
2 EBI-77889,EBI-2871302 REV3L  
  .error-prone translesion synthesis
.translesion synthesis
.DNA repair
.DNA-dependent DNA replication
.4 iron, 4 sulfur cluster binding
.metal ion binding
.3'-5' exonuclease activity
  + 3 more...
.zeta DNA polymerase complex
.nucleolus
.nucleoplasm
.nucleus
3 EBI-77889,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
4 EBI-77889,EBI-533224 TCF4  
  .protein-DNA complex assembly
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 3 more...
.E-box binding
.protein heterodimerization activity
.bHLH transcription factor binding
  + 9 more...
.transcription factor complex
.nucleus
5 EBI-77889,EBI-994813 CDC27  
  .protein K11-linked ubiquitination
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
.positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
  + 6 more...
.protein phosphatase binding .cytosol
.spindle
.centrosome
  + 4 more...
6 EBI-77889,EBI-307352 REL  
  .negative regulation of neuron death
.positive regulation of transcription from RNA polymerase II promoter
.innate immune response
  + 10 more...
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II distal enhancer sequence-specific DNA binding
.I-kappaB/NF-kappaB complex
.cytosol
.transcription factor complex
  + 2 more...
7 EBI-77889,EBI-367462 CDC20  
  .positive regulation of synapse maturation
.activation of anaphase-promoting complex activity
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 14 more...
.enzyme binding
.protein C-terminus binding
.perinuclear region of cytoplasm
.protein complex
.cytosol
  + 6 more...
8 EBI-77889,EBI-745305 IKZF1  
  .retina development in camera-type eye
.positive regulation of NK T cell differentiation
.Peyer's patch development
  + 17 more...
.metal ion binding
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.protein complex
.cytoplasm
.pericentric heterochromatin
.nucleus
9 EBI-77889,EBI-77903 ADAM9  
  .cellular response to lipopolysaccharide
.response to calcium ion
.positive regulation of keratinocyte migration
  + 23 more...
.laminin binding
.SH3 domain binding
.zinc ion binding
  + 5 more...
.extracellular exosome
.intrinsic component of external side of plasma membrane
.basolateral plasma membrane
  + 5 more...
10 EBI-77889,EBI-1058722 CAMK2B  
  .positive regulation of apoptotic signaling pathway
.regulation of cellular response to heat
.positive regulation of synapse maturation
  + 22 more...
.protein homodimerization activity
.ATP binding
.calmodulin-dependent protein kinase activity
.spindle midzone
.sarcoplasmic reticulum membrane
.endocytic vesicle membrane
  + 4 more...
11 EBI-77889,EBI-4397613 KCTD9  
  .protein homooligomerization .N/A .N/A
12 EBI-77889,EBI-2560420 CHAMP1  
  .attachment of mitotic spindle microtubules to kinetochore
.protein localization to microtubule
.protein localization to kinetochore
.sister chromatid biorientation
.metal ion binding
.nucleic acid binding
.spindle
.cytoplasm
.nucleoplasm
  + 3 more...
13 EBI-77889,EBI-724997 FZR1  
  .negative regulation of cell aging
.protein K11-linked ubiquitination
.lens fiber cell differentiation
  + 13 more...
.N/A .nuclear membrane
.cytosol
.nucleoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
ascites25
blood49
bone41
bone marrow20
brain18
connective tissue6
embryonic tissue136
eye19
heart33
intestine30
kidney18
liver24
lung38
lymph338
lymph node100
mammary gland46
muscle28
nerve64
ovary29
pancreas56
placenta17
prostate42
salivary gland246
skin66
stomach94
testis29
tonsil58
umbilical cord72
uterus34
Health State
TissuesTPM*
normal29
breast (mammary gland) tumor64
chondrosarcoma12
colorectal tumor35
gastrointestinal tumor143
germ cell tumor72
glioma102
head and neck tumor37
kidney tumor58
leukemia31
liver tumor41
lung tumor48
lymphoma235
ovarian tumor26
pancreatic tumor57
primitive neuroectodermal tumor of the CNS23
prostate cancer48
retinoblastoma21
skin tumor95
soft tissue/muscle tissue tumor55
uterine tumor22
Developmental Stage
TissuesTPM*
adult26
embryoid body157
blastocyst146
neonate32
fetus26
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue13.7
adrenal gland12.1
appendix22.5
bone marrow38.7
cerebral cortex14.8
colon9.6
duodenum10.2
esophagus9.9
gallbladder14.4
heart muscle14.5
kidney14.1
liver11.7
lung13.6
lymph node24.9
ovary12.5
pancreas14.1
placenta10.9
prostate12
salivary gland20
skin12.7
small intestine8.1
spleen14.6
stomach10.1
testis45.8
thyroid gland11
urinary bladder17.5
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604094, gene) Mitotic arrest-deficient 2, s. cerevisiae, homolog-like 2; MAD2L2OMIM


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