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> Protein (NX_Q9UIF7)
Protein (NX_Q9UIF7)
Protein
Gene SymbolMUTYH to neXtProt (NX_Q9UIF7)
DescriptionA/G-specific adenine DNA glycosylase
Chromosome1
Location1p34.1 (45794835 ~ 45806142) to Ensembl
Sequene Features : Isoforms 6, Variants 86, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.depurination
.mismatch repair
.base-excision repair, AP site formation
  + 2 more...
.4 iron, 4 sulfur cluster binding
.metal ion binding
.MutSalpha complex binding
.hydrolase activity, acting on glycosyl bonds
.mitochondrion
.nucleoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
6 86 2
2014-09-19protein level
6 64 2
2014-05-27protein level
6 64 2
2014-02-25protein level
6 64 2
2013-12-09protein level
6 52 2
2013-11-01protein level
6 51 2
2013-09-12protein level
6 51 2
2013-08-17protein level
6 51 2
2013-07-15protein level
6 44 0
2013-06-11protein level
6 44 0
2013-02-12protein level
6 27 0
2012-12-20protein level
6 24 0
2012-10-30protein level
6 29 0
2012-10-07protein level
6 29 0
2012-08-24protein level
6 29 0
2012-07-28protein level
6 29 0
2012-06-08protein level
6 29 0
2012-05-07protein level
6 30 0
2012-04-10protein level
6 30 0
2012-01-13protein level
6 26 0
2011-12-20protein level
6 26 0
2011-11-11protein level
6 26 0
2011-08-23protein level
6 26 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9UIF7-1
0 24 0 60031.2772
NX_Q9UIF7-2
0 24 0 59104.8806
NX_Q9UIF7-3
0 24 0 59033.8437
NX_Q9UIF7-4
0 24 0 58407.3538
NX_Q9UIF7-5
0 24 0 57480.9572
NX_Q9UIF7-6
0 24 0 57409.9203
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-10321956,EBI-741181 AGTRAP  
  .regulation of blood pressure
.response to hypoxia
.angiotensin type II receptor activity .intracellular membrane-bounded organelle
.cytoplasmic vesicle membrane
.integral component of membrane
  + 6 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
blood49
bone13
bone marrow20
brain30
cervix82
connective tissue20
embryonic tissue18
eye28
heart33
intestine30
kidney33
liver9
lung20
lymph135
lymph node44
mammary gland6
nerve128
ovary29
pancreas37
pituitary gland60
placenta38
prostate15
skin37
stomach135
testis11
thymus25
thyroid64
tonsil58
uterus21
Health State
TissuesTPM*
normal32
cervical tumor57
chondrosarcoma24
colorectal tumor44
gastrointestinal tumor42
germ cell tumor26
glioma55
head and neck tumor14
kidney tumor43
leukemia31
liver tumor10
lung tumor19
lymphoma152
non-neoplasia10
ovarian tumor26
pancreatic tumor57
primitive neuroectodermal tumor of the CNS7
prostate cancer19
retinoblastoma43
skin tumor55
soft tissue/muscle tissue tumor23
uterine tumor33
Developmental Stage
TissuesTPM*
adult32
embryoid body14
blastocyst32
fetus34
infant127
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue6.8
adrenal gland9.6
appendix13.9
bone marrow8.8
cerebral cortex7.8
colon11.1
duodenum15.8
esophagus7.8
gallbladder10.3
heart muscle6.4
kidney11
liver4.1
lung13.1
lymph node18.3
ovary15.5
pancreas5.9
placenta12.5
prostate12.7
salivary gland8.6
skin14.5
small intestine12.8
spleen17.1
stomach14.7
testis7.2
thyroid gland15
urinary bladder10.1
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604933, gene) Muty, e. coli, homolog of; MUTYHOMIM
2(#608456, phenotype) Familial adenomatous polyposis, 2; FAP2OMIM
3(#613659, phenotype) Gastric cancerOMIM
4colorectal;Adenomatous polyposis coliCGP


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