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> Protein (NX_Q9UIS9)
Protein (NX_Q9UIS9)
Protein
Gene SymbolMBD1 to neXtProt (NX_Q9UIS9)
DescriptionMethyl-CpG-binding domain protein 1
Chromosome18
Location18q21.1 (47793252 ~ 47808144) to Ensembl
Sequene Features : Isoforms 11, Variants 84, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of transcription, DNA-templated
.transcription from RNA polymerase II promoter
.methyl-CpG binding
.zinc ion binding
.transcription corepressor activity
  + 2 more...
.nuclear speck
.nuclear matrix
.cytoplasm
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
11 84 7
2014-09-19protein level
11 73 7
2014-05-27protein level
11 71 7
2014-02-25protein level
8 68 7
2013-12-09protein level
8 60 7
2013-11-01protein level
8 54 6
2013-09-12protein level
8 54 6
2013-08-17protein level
8 54 6
2013-07-15protein level
8 36 6
2013-06-11protein level
8 36 6
2013-02-12protein level
8 13 68
2012-12-20protein level
8 13 68
2012-10-30protein level
8 16 68
2012-10-07protein level
8 16 9
2012-08-24protein level
8 11 9
2012-07-28protein level
8 11 9
2012-06-08protein level
8 30 9
2012-05-07protein level
8 28 9
2012-04-10protein level
9 27 9
2012-01-13protein level
8 26 9
2011-12-20protein level
8 26 9
2011-11-11protein level
8 26 9
2011-08-23protein level
8 26 9
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9UIS9-1
0 24 0 66564.0159
NX_Q9UIS9-10
3 22 0 62598.0044
NX_Q9UIS9-11
1 19 0 58714.2257
NX_Q9UIS9-12
0 27 0 72079.2926
NX_Q9UIS9-2
0 24 0 64634.6719
NX_Q9UIS9-4
0 19 0 55131.5832
NX_Q9UIS9-5
0 23 0 61225.5535
NX_Q9UIS9-6
1 20 0 60808.82
NX_Q9UIS9-7
0 21 0 59962.9898
NX_Q9UIS9-8
0 21 0 59119.3952
NX_Q9UIS9-9
1 24 0 69571.7025
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-867196,EBI-607682 HDAC3  
  .cellular response to fluid shear stress
.spindle assembly
.neurotrophin TRK receptor signaling pathway
  + 21 more...
.NAD-dependent histone deacetylase activity (H3-K18 specific)
.NF-kappaB binding
.NAD-dependent histone deacetylase activity (H4-K16 specific)
  + 11 more...
.transcriptional repressor complex
.plasma membrane
.spindle microtubule
  + 5 more...
2 EBI-867196,EBI-349968 SUV39H1  
  .cellular response to hypoxia
.rhythmic process
.negative regulation of transcription, DNA-templated
  + 15 more...
.protein N-terminus binding
.histone methyltransferase activity (H3-K9 specific)
.histone methyltransferase activity
  + 5 more...
.rDNA heterochromatin
.chromatin silencing complex
.nucleoplasm
  + 5 more...
3 EBI-867196,EBI-629434 PIAS1  
  .protein-DNA complex assembly
.regulation of interferon-gamma-mediated signaling pathway
.interferon-gamma-mediated signaling pathway
  + 14 more...
.SUMO ligase activity
.androgen receptor binding
.enzyme binding
  + 5 more...
.nuclear speck
.PML body
.nucleoplasm
.nucleus
4 EBI-867196,EBI-466029 HTT  
  .negative regulation of extrinsic apoptotic signaling pathway
.iron ion homeostasis
.L-glutamate import
  + 38 more...
.diazepam binding
.beta-tubulin binding
.dynein intermediate chain binding
  + 6 more...
.protein complex
.cytoplasmic vesicle membrane
.dendrite
  + 11 more...
5 EBI-867196,EBI-78219 CBX5  
  .negative regulation of transcription, DNA-templated
.viral process
.blood coagulation
.repressing transcription factor binding
.methylated histone binding
.protein binding, bridging
.chromatin binding
.histone methyltransferase complex
.nuclear pericentric heterochromatin
.transcriptional repressor complex
  + 8 more...
6 EBI-867196,EBI-80140 SUMO1  
  .protein localization to nuclear pore
.regulation of interferon-gamma-mediated signaling pathway
.interferon-gamma-mediated signaling pathway
  + 13 more...
.poly(A) RNA binding
.ubiquitin protein ligase binding
.SUMO transferase activity
.transcription factor binding
.synapse
.nuclear membrane
.dendrite
  + 8 more...
7 EBI-867196,EBI-1020839 CHAF1A  
  .chromatin assembly
.cell cycle
.protein complex assembly
  + 3 more...
.chromo shadow domain binding
.unfolded protein binding
.identical protein binding
.chromatin binding
.protein complex
.CAF-1 complex
.nuclear chromatin
8 EBI-867196,EBI-301834 HDAC1  
  .histone H4 deacetylation
.histone H3 deacetylation
.fungiform papilla formation
  + 34 more...
.NAD-dependent histone deacetylase activity (H3-K18 specific)
.repressing transcription factor binding
.NF-kappaB binding
  + 17 more...
.protein complex
.NuRD complex
.Sin3 complex
  + 7 more...
9 EBI-867196,EBI-79691 SETDB1  
  .bone development
.histone H3-K9 trimethylation
.transcription, DNA-templated
  + 3 more...
.histone-lysine N-methyltransferase activity
.zinc ion binding
.DNA binding
.intracellular membrane-bounded organelle
.plasma membrane
.cytoplasm
  + 3 more...
10 EBI-867196,EBI-301821 HDAC2  
  .negative regulation of intrinsic apoptotic signaling pathway
.regulation of protein deacetylation
.negative regulation of canonical Wnt signaling pathway
  + 44 more...
.NAD-dependent histone deacetylase activity (H3-K18 specific)
.NF-kappaB binding
.NAD-dependent histone deacetylase activity (H4-K16 specific)
  + 14 more...
.protein complex
.ESC/E(Z) complex
.NuRD complex
  + 8 more...
11 EBI-867196,EBI-2803703 PIAS3  
  .positive regulation of membrane potential
.positive regulation of protein sumoylation
.protein sumoylation
  + 4 more...
.enzyme binding
.SUMO transferase activity
.ligase activity
  + 3 more...
.synapse
.dendrite
.cytoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland91
ascites50
bladder66
blood40
bone153
bone marrow82
brain90
cervix41
connective tissue40
embryonic tissue75
eye153
heart122
intestine73
kidney47
liver68
lung62
lymph node33
mammary gland26
mouth105
muscle18
ovary68
pancreas60
parathyroid48
pharynx24
placenta49
prostate94
skin42
spleen56
stomach62
testis291
thymus138
thyroid42
trachea57
uterus73
vascular77
Health State
TissuesTPM*
normal89
adrenal tumor237
bladder carcinoma113
breast (mammary gland) tumor42
cervical tumor57
chondrosarcoma132
colorectal tumor26
gastrointestinal tumor67
germ cell tumor102
glioma18
head and neck tumor59
kidney tumor14
leukemia63
liver tumor124
lung tumor77
lymphoma13
non-neoplasia51
ovarian tumor78
pancreatic tumor76
primitive neuroectodermal tumor of the CNS94
prostate cancer77
retinoblastoma21
skin tumor23
soft tissue/muscle tissue tumor47
uterine tumor55
Developmental Stage
TissuesTPM*
adult82
embryoid body57
blastocyst146
neonate32
fetus73
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue21
adrenal gland26.1
appendix35.1
bone marrow39.5
cerebral cortex27.3
colon21
duodenum28.7
esophagus23.8
gallbladder26.9
heart muscle23.1
kidney21.9
liver11.5
lung27.8
lymph node36.1
ovary30.1
pancreas15.9
placenta30.8
prostate26.4
salivary gland24.9
skin34.9
small intestine27.3
spleen38.4
stomach29.3
testis76.6
thyroid gland30.8
urinary bladder25.5
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowMedium
breastMedium
bronchusMedium
cerebellumLow
cerebral cortexMedium
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
gallbladderMedium
heart muscleMedium
hippocampusLow
kidneyMedium
lateral ventricleLow
liverMedium
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaMedium
ovaryMedium
pancreasLow
parathyroid glandMedium
placentaMedium
prostateLow
rectumMedium
salivary glandLow
seminal vesicleLow
skeletal muscleLow
skin 1Medium
skin 2Low
small intestineHigh
smooth muscleLow
soft tissue 1Medium
soft tissue 2Medium
spleenMedium
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandLow
tonsilMedium
urinary bladderLow
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*156535, gene) Methyl-cpg-binding domain protein 1; MBD1OMIM


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