Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_Q9UIV1)
Protein (NX_Q9UIV1)
Protein
Gene SymbolCNOT7 to neXtProt (NX_Q9UIV1)
DescriptionCCR4-NOT transcription complex subunit 7
Chromosome8
Location8p22 (17086737 ~ 17104387) to Ensembl
Sequene Features : Isoforms 2, Variants 29, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.RNA phosphodiester bond hydrolysis, exonucleolytic
.positive regulation of mRNA catabolic process
  + 17 more...
.metal ion binding
.signal transducer activity
.poly(A)-specific ribonuclease activity
  + 4 more...
.CCR4-NOT complex
.membrane
.cytosol
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 29 3
2014-09-19protein level
2 21 3
2014-05-27protein level
2 21 3
2014-02-25protein level
2 21 3
2013-12-09protein level
2 16 3
2013-11-01protein level
2 15 3
2013-09-12protein level
2 15 3
2013-08-17protein level
2 15 3
2013-07-15protein level
2 10 0
2013-06-11protein level
2 10 0
2013-02-12protein level
1 2 0
2012-12-20protein level
1 3 0
2012-10-30protein level
1 3 0
2012-10-07protein level
1 3 0
2012-08-24protein level
1 2 0
2012-07-28protein level
1 2 0
2012-06-08protein level
1 3 0
2012-05-07protein level
1 3 0
2012-04-10protein level
1 3 0
2012-01-13protein level
1 3 0
2011-12-20protein level
1 3 0
2011-11-11protein level
1 3 0
2011-08-23protein level
1 3 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9UIV1-1
2 12 0 32723.8511
NX_Q9UIV1-2
0 12 0 28209.95
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2105113,EBI-1222758 CNOT1  
  .regulation of stem cell maintenance
.positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.RNA phosphodiester bond hydrolysis, exonucleolytic
  + 13 more...
.armadillo repeat domain binding
.poly(A) RNA binding
.retinoic acid receptor binding
  + 3 more...
.CCR4-NOT complex
.membrane
.cytosol
  + 4 more...
2 EBI-2105113,EBI-723281 TOB1  
  .positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
.negative regulation of nuclear-transcribed mRNA poly(A) tail shortening
  + 6 more...
.receptor tyrosine kinase binding
.SH3/SH2 adaptor activity
.transcription corepressor activity
.CCR4-NOT complex
.cytoplasm
.nucleus
3 EBI-2105113,EBI-742279 BTG1  
  .positive regulation of fibroblast apoptotic process
.positive regulation of angiogenesis
.positive regulation of myoblast differentiation
  + 5 more...
.kinase binding
.enzyme binding
.transcription cofactor activity
.cytoplasm
.nucleus
4 EBI-2105113,EBI-1047576 BTG2  
  .negative regulation of neural precursor cell proliferation
.positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
.response to electrical stimulus
  + 15 more...
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription .extracellular exosome
5 EBI-2105113,EBI-2562000 TOB2  
  .positive regulation of ossification
.negative regulation of osteoclast differentiation
.regulation of gene expression
  + 2 more...
.N/A .cytoplasm
.nucleus
6 EBI-2105113,EBI-528269 AGO2  
  .positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.mRNA cleavage involved in gene silencing by siRNA
.RNA phosphodiester bond hydrolysis, endonucleolytic
  + 25 more...
.endoribonuclease activity, cleaving miRNA-paired mRNA
.pre-miRNA binding
.endoribonuclease activity, cleaving siRNA-paired mRNA
  + 12 more...
.RISC-loading complex
.micro-ribonucleoprotein complex
.ribonucleoprotein complex
  + 9 more...
7 EBI-2105113,EBI-2104530 CNOT6  
  .positive regulation of ligand-dependent nuclear receptor transcription coactivator activity
.RNA phosphodiester bond hydrolysis, exonucleolytic
.nuclear-transcribed mRNA catabolic process, no-go decay
  + 10 more...
.metal ion binding
.poly(A)-specific ribonuclease activity
.exoribonuclease activity
.RNA binding
.CCR4-NOT complex
.membrane
.cytosol
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites50
bladder267
blood40
bone111
bone marrow102
brain5
cervix41
connective tissue181
embryonic tissue4
eye9
heart11
intestine60
kidney47
liver126
lung5
lymph45
lymph node111
mammary gland6
mouth45
muscle141
nerve64
ovary9
pancreas28
pharynx49
placenta3
prostate47
salivary gland98
skin47
spleen18
stomach52
testis2
thymus50
thyroid21
tonsil58
trachea19
umbilical cord145
uterus107
vascular116
Health State
TissuesTPM*
normal74
bladder carcinoma284
breast (mammary gland) tumor10
cervical tumor57
chondrosarcoma120
colorectal tumor44
gastrointestinal tumor75
germ cell tumor113
glioma46
head and neck tumor22
kidney tumor43
leukemia105
liver tumor114
lung tumor68
lymphoma27
non-neoplasia51
ovarian tumor144
pancreatic tumor76
primitive neuroectodermal tumor of the CNS94
prostate cancer48
retinoblastoma129
skin tumor63
soft tissue/muscle tissue tumor295
uterine tumor55
Developmental Stage
TissuesTPM*
adult8
embryoid body14
blastocyst48
neonate64
fetus1
infant85
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue21.9
adrenal gland32.6
appendix33.3
bone marrow26.4
cerebral cortex29.8
colon31.5
duodenum28.6
esophagus28.8
gallbladder26.7
heart muscle25.5
kidney33
liver20.4
lung25.5
lymph node44.1
ovary39.2
pancreas16.4
placenta33.2
prostate29.6
salivary gland26.6
skin23.4
small intestine29.4
spleen30.1
stomach28.4
testis35
thyroid gland49.8
urinary bladder36.3
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*604913, gene) Ccr4-not transcription complex, subunit 7; CNOT7OMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center