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> Protein (NX_Q9UJ41)
Protein (NX_Q9UJ41)
Protein
Gene SymbolRABGEF1 to neXtProt (NX_Q9UJ41)
DescriptionRab5 GDP/GTP exchange factor
Chromosome7
Location7q11.21 (66093868 ~ 66276446) to Ensembl
Sequene Features : Isoforms 4, Variants 53, PTMs 18 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of Kit signaling pathway
.negative regulation of interleukin-6 secretion
.regulation of Fc receptor mediated stimulatory signaling pathway
  + 9 more...
.Rab GTPase binding
.Rab guanyl-nucleotide exchange factor activity
.zinc ion binding
  + 2 more...
.recycling endosome
.vesicle
.early endosome
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 53 18
2014-09-19protein level
4 44 18
2014-05-27protein level
4 44 18
2014-02-25protein level
3 9 18
2013-12-09protein level
3 2 19
2013-11-01protein level
3 2 13
2013-09-12protein level
3 2 13
2013-08-17protein level
3 2 13
2013-07-15protein level
3 2 10
2013-06-11protein level
3 2 10
2013-02-12protein level
3 2 33
2012-12-20protein level
3 2 33
2012-10-30protein level
3 4 33
2012-10-07protein level
3 4 11
2012-08-24protein level
3 4 11
2012-07-28protein level
3 4 11
2012-06-08protein level
3 9 11
2012-05-07protein level
3 9 11
2012-04-10protein level
3 9 11
2012-01-13protein level
3 9 11
2011-12-20protein level
3 9 11
2011-11-11protein level
3 9 7
2011-08-23protein level
3 9 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9UJ41-1
6 23 0 79320.513
NX_Q9UJ41-2
0 22 0 56854.479
NX_Q9UJ41-3
0 23 0 61260.8175
NX_Q9UJ41-4
1 22 0 58488.2812
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-913954,EBI-297353 EGFR  
  .cellular response to dexamethasone stimulus
.cellular response to estradiol stimulus
.cellular response to epidermal growth factor stimulus
  + 73 more...
.actin filament binding
.protein heterodimerization activity
.identical protein binding
  + 12 more...
.multivesicular body, internal vesicle lumen
.Shc-EGFR complex
.perinuclear region of cytoplasm
  + 19 more...
2 EBI-913954,EBI-413034 UBB  
  .positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator
.regulation of neuron death
.programmed necrotic cell death
  + 96 more...
.N/A .extracellular exosome
.neuronal cell body
.neuron projection
  + 6 more...
3 EBI-913954,EBI-724310 DAZAP2  
  .N/A .WW domain binding .cytoplasm
.nucleus
4 EBI-913954,EBI-740767 ZC2HC1C  
  .N/A .metal ion binding .N/A
5 EBI-913954,EBI-1765605 THOC1  
  .negative regulation of DNA damage checkpoint
.negative regulation of isotype switching to IgA isotypes
.viral mRNA export from host cell nucleus
  + 11 more...
.RNA binding
.DNA binding
.intercellular bridge
.nuclear speck
.nuclear matrix
  + 6 more...
6 EBI-913954,EBI-2932492 TXN2  
  .oxidation-reduction process
.response to axon injury
.cell redox homeostasis
  + 12 more...
.peptide-methionine (R)-S-oxide reductase activity
.oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
.protein disulfide oxidoreductase activity
.peptide-methionine (S)-S-oxide reductase activity
.neuronal cell body
.dendrite
.mitochondrial matrix
  + 2 more...
7 EBI-913954,EBI-739657 KXD1  
  .vesicle-mediated transport .N/A .BLOC-1 complex
8 EBI-913954,EBI-2130429 TRIM54  
  .cell differentiation
.multicellular organismal development
.signal transduction
  + 2 more...
.zinc ion binding
.signal transducer activity
.Z disc
.microtubule associated complex
.microtubule
9 EBI-913954,EBI-2342111 TRIM15  
  .negative regulation of viral release from host cell
.negative regulation of intracellular transport of viral material
.positive regulation of RIG-I signaling pathway
  + 5 more...
.zinc ion binding .intracellular
10 EBI-913954,EBI-5654244 CIPC  
  .rhythmic process
.negative regulation of transcription, DNA-templated
.negative regulation of circadian rhythm
.transcription, DNA-templated
.N/A .nucleus
11 EBI-913954,EBI-465781 BLOC1S6  
  .membrane fusion
.membrane organization
.positive regulation of pigment cell differentiation
  + 12 more...
.actin filament binding
.protein homodimerization activity
.identical protein binding
.syntaxin binding
.BLOC-1 complex
.transport vesicle
.extrinsic component of membrane
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue233
adrenal gland30
blood73
bone69
brain35
cervix61
connective tissue60
embryonic tissue32
esophagus99
eye62
heart22
intestine51
kidney66
larynx42
liver19
lung41
lymph45
lymph node77
mammary gland26
muscle47
nerve64
ovary88
pancreas14
pharynx24
pituitary gland60
placenta24
prostate52
skin61
spleen18
stomach73
testis82
thymus25
thyroid21
trachea96
uterus47
Health State
TissuesTPM*
normal3
breast (mammary gland) tumor10
cervical tumor86
chondrosarcoma144
colorectal tumor35
esophageal tumor115
gastrointestinal tumor50
germ cell tumor41
glioma37
head and neck tumor7
liver tumor10
lung tumor9
Developmental Stage
TissuesTPM*
adult57
embryoid body42
blastocyst48
neonate96
fetus44
infant42
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue7.4
adrenal gland12.4
appendix10.8
bone marrow14.7
cerebral cortex15.3
colon7.8
duodenum5.8
esophagus11.2
gallbladder11.3
heart muscle7.7
kidney7.5
liver2.6
lung9.1
lymph node14
ovary16
pancreas2.6
placenta10.4
prostate12.2
salivary gland4.3
skin7.4
small intestine9
spleen11.3
stomach9.7
testis32.8
thyroid gland12.6
urinary bladder10.1
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*609700, gene) Rab guanine nucleotide exchange factor 1; RABGEF1OMIM


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