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> Protein (NX_Q9UJ70)
Protein (NX_Q9UJ70)
Protein
Gene SymbolNAGK to neXtProt (NX_Q9UJ70)
DescriptionN-acetyl-D-glucosamine kinase
Chromosome2
Location2p13.3 (71291474 ~ 71306935) to Ensembl
Sequene Features : Isoforms 2, Variants 43, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.carbohydrate phosphorylation
.N-acetylneuraminate catabolic process
.N-acetylmannosamine metabolic process
.N-acetylglucosamine metabolic process
.N-acetylglucosamine kinase activity
.N-acylmannosamine kinase activity
.ATP binding
.extracellular exosome
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 43 5
2014-09-19protein level
2 34 5
2014-05-27protein level
2 34 5
2014-02-25protein level
2 34 5
2013-12-09protein level
2 25 5
2013-11-01protein level
2 25 5
2013-09-12protein level
2 25 4
2013-08-17protein level
2 25 4
2013-07-15protein level
2 17 3
2013-06-11protein level
2 17 3
2013-02-12protein level
2 9 4
2012-12-20protein level
2 13 4
2012-10-30protein level
1 15 2
2012-10-07protein level
1 15 2
2012-08-24protein level
1 15 2
2012-07-28protein level
1 15 2
2012-06-08protein level
1 20 2
2012-05-07protein level
1 19 2
2012-04-10protein level
1 19 2
2012-01-13protein level
1 9 2
2011-12-20protein level
1 9 2
2011-11-11protein level
1 9 2
2011-08-23protein level
1 9 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9UJ70-1
1 16 0 37351.816
NX_Q9UJ70-2
3 16 0 42011.0471
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-372578,EBI-727004 SDCBP  
  .positive regulation of extracellular exosome assembly
.positive regulation of exosomal secretion
.ephrin receptor signaling pathway
  + 9 more...
.protein N-terminus binding
.protein heterodimerization activity
.syndecan binding
  + 4 more...
.blood microparticle
.extracellular exosome
.melanosome
  + 12 more...
2 EBI-372578,EBI-711290 CDKN2C  
  .negative regulation of protein serine/threonine kinase activity
.oligodendrocyte differentiation
.negative regulation of phosphorylation
  + 6 more...
.protein kinase binding
.cyclin-dependent protein serine/threonine kinase inhibitor activity
.cytosol
.cytoplasm
.nucleus
3 EBI-372578,EBI-2864512 MEOX1  
  .sclerotome development
.somite development
.hematopoietic stem cell differentiation
  + 2 more...
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.chromatin binding
  + 3 more...
.cytoplasm
.nucleus
4 EBI-372578,EBI-307352 REL  
  .negative regulation of neuron death
.positive regulation of transcription from RNA polymerase II promoter
.innate immune response
  + 10 more...
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II distal enhancer sequence-specific DNA binding
.I-kappaB/NF-kappaB complex
.cytosol
.transcription factor complex
  + 2 more...
5 EBI-372578,EBI-739832 LNX1  
  .protein homooligomerization
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.cytoplasm
6 EBI-372578,EBI-722877 TCF12  
  .positive regulation of transcription from RNA polymerase II promoter
.positive regulation of neuron differentiation
.muscle organ development
  + 2 more...
.E-box binding
.protein heterodimerization activity
.SMAD binding
  + 7 more...
.RNA polymerase II transcription factor complex
.cytoplasm
.nucleus
.nuclear chromatin
7 EBI-372578,EBI-2559426 ACTR10  
  .microtubule-based movement .N/A .dynactin complex
.cytoplasm
8 EBI-372578,EBI-347111 DACH1  
  .negative regulation of DNA biosynthetic process
.negative regulation of cell proliferation involved in contact inhibition
.negative regulation of fibroblast proliferation
  + 7 more...
.DNA binding
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
.RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly
.intracellular membrane-bounded organelle
.cytoplasm
.nucleolus
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder66
blood122
bone83
bone marrow41
brain58
cervix20
connective tissue40
embryonic tissue32
esophagus49
eye90
heart78
intestine68
kidney52
liver43
lung92
lymph67
lymph node44
mammary gland59
mouth15
muscle56
ovary39
pancreas65
parathyroid48
pharynx147
placenta52
prostate31
salivary gland49
skin37
spleen262
stomach20
testis85
thymus125
thyroid21
trachea57
uterus38
vascular19
Health State
TissuesTPM*
normal59
bladder carcinoma113
breast (mammary gland) tumor85
cervical tumor28
chondrosarcoma108
colorectal tumor35
esophageal tumor57
gastrointestinal tumor8
germ cell tumor26
glioma65
kidney tumor101
leukemia148
liver tumor31
lung tumor87
lymphoma69
non-neoplasia103
ovarian tumor39
pancreatic tumor123
primitive neuroectodermal tumor of the CNS7
prostate cancer9
skin tumor39
soft tissue/muscle tissue tumor23
uterine tumor22
Developmental Stage
TissuesTPM*
adult68
embryoid body28
blastocyst32
fetus53
infant42
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue50.3
adrenal gland41.9
appendix91.6
bone marrow29
cerebral cortex38.5
colon43.3
duodenum33.7
esophagus144.6
gallbladder70.5
heart muscle33.1
kidney37.3
liver26.9
lung54.5
lymph node108.6
ovary48.1
pancreas25.5
placenta67.6
prostate39.8
salivary gland78.4
skin96.8
small intestine36.9
spleen129
stomach37.8
testis52.1
thyroid gland36.4
urinary bladder76.8
Tissues
TissuesExpression level
adrenal glandLow
appendixLow
bone marrowLow
breastLow
cerebellumLow
cerebral cortexMedium
colonLow
endometrium 1Low
epididymisLow
esophagusMedium
gallbladderMedium
heart muscleLow
kidneyLow
lungMedium
lymph nodeHigh
nasopharynxLow
oral mucosaLow
pancreasMedium
placentaMedium
prostateLow
salivary glandMedium
seminal vesicleLow
skin 1Low
skin 2Low
soft tissue 1Low
soft tissue 2Low
spleenMedium
stomach 1Medium
stomach 2Low
testisLow
thyroid glandLow
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*606828, gene) N-acetylglucosamine kinase; NAGKOMIM


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