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> Protein (NX_Q9UJM3)
Protein (NX_Q9UJM3)
Protein
Gene SymbolERRFI1 to neXtProt (NX_Q9UJM3)
DescriptionERBB receptor feedback inhibitor 1
Chromosome1
Location1p36.23 (8064464 ~ 8086368) to Ensembl
Sequene Features : Isoforms 1, Variants 46, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.lung epithelium development
.lung vasculature development
.lung alveolus development
  + 6 more...
.protein kinase binding
.GTPase activator activity
.extrinsic component of cytoplasmic side of plasma membrane
.cytoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 46 7
2014-09-19protein level
1 38 7
2014-05-27protein level
1 38 7
2014-02-25protein level
1 36 7
2013-12-09protein level
1 28 7
2013-11-01protein level
1 27 7
2013-09-12protein level
1 27 5
2013-08-17protein level
1 27 5
2013-07-15protein level
1 20 5
2013-06-11protein level
1 20 5
2013-02-12protein level
1 13 7
2012-12-20protein level
1 13 7
2012-10-30protein level
1 17 7
2012-10-07protein level
1 17 7
2012-08-24protein level
1 11 7
2012-07-28protein level
1 11 7
2012-06-08protein level
1 16 7
2012-05-07protein level
1 16 7
2012-04-10protein level
1 16 7
2012-01-13protein level
1 13 7
2011-12-20protein level
1 13 7
2011-11-11protein level
1 13 7
2011-08-23protein level
1 13 7
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9UJM3-1
23 0 0 50528.0884
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2941912,EBI-974488 CHEK1  
  .regulation of histone H3-K9 acetylation
.negative regulation of DNA biosynthetic process
.replicative senescence
  + 17 more...
.histone kinase activity (H3-T11 specific)
.ATP binding
.protein serine/threonine kinase activity
.protein kinase activity
.intracellular membrane-bounded organelle
.cytosol
.centrosome
  + 6 more...
2 EBI-2941912,EBI-297353 EGFR  
  .cellular response to dexamethasone stimulus
.cellular response to estradiol stimulus
.cellular response to epidermal growth factor stimulus
  + 73 more...
.actin filament binding
.protein heterodimerization activity
.identical protein binding
  + 12 more...
.multivesicular body, internal vesicle lumen
.Shc-EGFR complex
.perinuclear region of cytoplasm
  + 19 more...
3 EBI-2941912,EBI-641062 ERBB2  
  .regulation of ERK1 and ERK2 cascade
.positive regulation of epithelial cell proliferation
.oligodendrocyte differentiation
  + 35 more...
.protein dimerization activity
.protein heterodimerization activity
.ErbB-3 class receptor binding
  + 9 more...
.perinuclear region of cytoplasm
.receptor complex
.cytoplasmic vesicle
  + 7 more...
4 EBI-2941912,EBI-476295 SFN  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.negative regulation of protein serine/threonine kinase activity
  + 20 more...
.protein kinase C inhibitor activity .extracellular exosome
.cytoplasmic vesicle membrane
.cytosol
  + 3 more...
5 EBI-2941912,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
ascites50
blood8
bone195
brain33
cervix61
connective tissue295
ear186
embryonic tissue192
esophagus49
eye67
heart33
intestine125
kidney189
larynx42
liver355
lung95
mammary gland72
mouth30
muscle47
nerve128
ovary39
pancreas163
parathyroid97
pituitary gland60
placenta70
prostate89
skin42
stomach282
testis34
thymus25
thyroid364
trachea77
uterus150
Health State
TissuesTPM*
normal96
breast (mammary gland) tumor21
cervical tumor86
chondrosarcoma313
colorectal tumor142
esophageal tumor57
gastrointestinal tumor194
germ cell tumor64
glioma27
head and neck tumor119
kidney tumor58
liver tumor416
lung tumor97
non-neoplasia134
ovarian tumor52
pancreatic tumor199
primitive neuroectodermal tumor of the CNS7
prostate cancer105
skin tumor39
soft tissue/muscle tissue tumor151
uterine tumor110
Developmental Stage
TissuesTPM*
adult128
embryoid body414
blastocyst179
fetus70
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue109.6
adrenal gland40.2
appendix30.1
cerebral cortex14.7
colon33
duodenum29.9
esophagus51.3
gallbladder133.8
heart muscle8.4
kidney67
liver365.6
lung38.6
lymph node16.4
ovary125.7
pancreas304.4
placenta99.8
prostate22.4
salivary gland33.4
skin10.8
small intestine39.8
spleen7.4
stomach29.5
testis16.2
thyroid gland78.3
urinary bladder40.4
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*608069, gene) Erbb receptor feedback inhibitor 1; ERRFI1OMIM


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