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> Protein (NX_Q9UJX2)
Protein (NX_Q9UJX2)
Protein
Gene SymbolCDC23 to neXtProt (NX_Q9UJX2)
DescriptionCell division cycle protein 23 homolog
Chromosome5
Location5q31.2 (137523339 ~ 137549032) to Ensembl
Sequene Features : Isoforms 3, Variants 51, PTMs 14 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.protein K11-linked ubiquitination
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
.positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
  + 11 more...
.ubiquitin-protein transferase activity .cytosol
.anaphase-promoting complex
.nucleoplasm
.intracellular
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 51 14
2014-09-19protein level
3 36 14
2014-05-27protein level
3 36 14
2014-02-25protein level
3 36 14
2013-12-09protein level
3 32 14
2013-11-01protein level
3 31 14
2013-09-12protein level
3 31 13
2013-08-17protein level
3 31 13
2013-07-15protein level
3 21 9
2013-06-11protein level
3 21 9
2013-02-12protein level
3 10 22
2012-12-20protein level
3 10 22
2012-10-30protein level
3 11 22
2012-10-07protein level
3 11 11
2012-08-24protein level
3 6 11
2012-07-28protein level
3 6 11
2012-06-08protein level
3 10 11
2012-05-07protein level
3 10 11
2012-04-10protein level
3 10 11
2012-01-13protein level
3 10 11
2011-12-20protein level
3 10 11
2011-11-11protein level
3 10 11
2011-08-23protein level
3 10 11
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9UJX2-1
0 31 0 68789.7967
NX_Q9UJX2-2
1 5 0 16810.6643
NX_Q9UJX2-3
0 26 0 55846.1652
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-396137,EBI-1221934 APOL1  
  .chloride transmembrane transport
.innate immune response
.lipoprotein metabolic process
  + 6 more...
.lipid binding
.chloride channel activity
.blood microparticle
.high-density lipoprotein particle
.very-low-density lipoprotein particle
  + 3 more...
2 EBI-396137,EBI-1059030 FSBP  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.identical protein binding .nucleus
3 EBI-396137,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
4 EBI-396137,EBI-3505701 SOX5  
  .positive regulation of mesenchymal stem cell differentiation
.cellular response to transforming growth factor beta stimulus
.positive regulation of cartilage development
  + 10 more...
.transcription regulatory region DNA binding
.sequence-specific DNA binding transcription factor activity
.sequence-specific DNA binding RNA polymerase II transcription factor activity
.nuclear transcription factor complex
5 EBI-396137,EBI-945751 COIL  
  .N/A .identical protein binding
.protein C-terminus binding
.membrane
.Cajal body
.cytoplasm
  + 3 more...
6 EBI-396137,EBI-413628 RAC1  
  .positive regulation of substrate adhesion-dependent cell spreading
.apoptotic signaling pathway
.ruffle assembly
  + 63 more...
.Rho GDP-dissociation inhibitor binding
.thioesterase binding
.enzyme binding
  + 2 more...
.extracellular exosome
.melanosome
.cytoplasmic ribonucleoprotein granule
  + 12 more...
7 EBI-396137,EBI-6509505 INCA1  
  .positive regulation of apoptotic signaling pathway
.negative regulation of cyclin-dependent protein serine/threonine kinase activity
.negative regulation of cell proliferation
.cyclin binding
.cyclin-dependent protein serine/threonine kinase inhibitor activity
.cytoplasm
.nucleus
8 EBI-396137,EBI-358049 BYSL  
  .cell proliferation
.female pregnancy
.cell adhesion
  + 2 more...
.poly(A) RNA binding .apical part of cell
.intracellular membrane-bounded organelle
.membrane
  + 3 more...
9 EBI-396137,EBI-10236940 INPP5J  
  .phosphatidylinositol dephosphorylation
.small molecule metabolic process
.inositol phosphate metabolic process
  + 5 more...
.inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity
.inositol-1,4,5-trisphosphate 5-phosphatase activity
.phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
.inositol-polyphosphate 5-phosphatase activity
.dendritic shaft
.growth cone
.plasma membrane
  + 3 more...
10 EBI-396137,EBI-744761 CYB5R2  
  .oxidation-reduction process
.sterol biosynthetic process
.cytochrome-b5 reductase activity, acting on NAD(P)H .membrane
.mitochondrion
.nucleus
11 EBI-396137,EBI-747107 SIAH1  
  .positive regulation of intrinsic apoptotic signaling pathway
.neuron apoptotic process
.proteasome-mediated ubiquitin-dependent protein catabolic process
  + 11 more...
.ubiquitin protein ligase activity
.identical protein binding
.ligase activity
  + 3 more...
.beta-catenin destruction complex
.plasma membrane
.cytosol
  + 3 more...
12 EBI-396137,EBI-8638439 CCDC36  
  .positive regulation of defense response to virus by host .N/A .N/A
13 EBI-396137,EBI-10175124 FAM9B  
  .spermatid development .N/A .nucleoplasm
14 EBI-396137,EBI-1104933 CCDC24  
  .N/A .N/A .N/A
15 EBI-396137,EBI-741724 SPERT  
  .N/A .N/A .cytoplasmic membrane-bounded vesicle
16 EBI-396137,EBI-2511344 KCTD6  
  .protein homooligomerization .ankyrin binding .N/A
17 EBI-396137,EBI-10269922 RBM15B  
  .viral process
.RNA splicing
.mRNA processing
  + 3 more...
.poly(A) RNA binding
.RNA binding
.nucleotide binding
.nucleoplasm
18 EBI-396137,EBI-747353 ATRIP  
  .DNA repair
.DNA replication
.DNA damage checkpoint
.K63-linked polyubiquitin binding .nucleoplasm
.nucleus
19 EBI-396137,EBI-740322 RBPMS  
  .positive regulation of SMAD protein import into nucleus
.positive regulation of pathway-restricted SMAD protein phosphorylation
.RNA processing
  + 2 more...
.poly(A) RNA binding
.poly(A) binding
.transcription coactivator activity
.nucleotide binding
.cytoplasm
.nucleoplasm
20 EBI-396137,EBI-748974 OPTN  
  .Golgi ribbon formation
.defense response to Gram-negative bacterium
.negative regulation of I-kappaB kinase/NF-kappaB signaling
  + 10 more...
.K63-linked polyubiquitin binding
.identical protein binding
.polyubiquitin binding
  + 2 more...
.recycling endosome
.perinuclear region of cytoplasm
.cytoplasmic membrane-bounded vesicle
  + 8 more...
21 EBI-396137,EBI-10171633 PNMA5  
  .positive regulation of apoptotic process .identical protein binding .N/A
22 EBI-396137,EBI-741037 LZTS2  
  .negative regulation of protein localization to nucleus
.negative regulation of canonical Wnt signaling pathway
.spindle midzone assembly
  + 7 more...
.N/A .midbody
.microtubule
.centrosome
.cytoplasm
23 EBI-396137,EBI-739773 CRACR2A  
  .positive regulation of calcium ion transport
.activation of store-operated calcium channel activity
.immune system process
.store-operated calcium entry
.calcium ion binding .membrane
.Golgi apparatus
.cytoplasm
  + 2 more...
24 EBI-396137,EBI-744115 CEP44  
  .N/A .N/A .midbody
.centrosome
.cytoplasm
.spindle pole
25 EBI-396137,EBI-748028 EIF5A2  
  .mRNA transport
.positive regulation of translational termination
.positive regulation of translational elongation
  + 8 more...
.ribosome binding
.translation elongation factor activity
.cytosol
.endoplasmic reticulum membrane
.nuclear pore
26 EBI-396137,EBI-6083685 BCAS3  
  .positive regulation of actin cytoskeleton reorganization
.regulation of establishment of cell polarity
.activation of GTPase activity
  + 16 more...
.beta-tubulin binding
.histone binding
.nuclear hormone receptor binding
  + 4 more...
.cell periphery
.intermediate filament cytoskeleton
.transcriptionally active chromatin
  + 4 more...
27 EBI-396137,EBI-739467 GORASP2  
  .organelle organization
.mitotic cell cycle
.N/A .membrane
.Golgi apparatus
.Golgi membrane
28 EBI-396137,EBI-10309896 SLC52A2  
  .riboflavin transport .riboflavin transporter activity
.virus receptor activity
.integral component of plasma membrane
29 EBI-396137,EBI-749321 RSL24D1  
  .ribosome biogenesis
.translation
.structural constituent of ribosome .ribosome
.nucleolus
.nucleus
30 EBI-396137,EBI-2212028 SSX2IP  
  .regulation of cell motility
.centrosome organization
.cilium assembly
  + 3 more...
.N/A .protein complex
.ciliary basal body
.centriolar satellite
  + 3 more...
31 EBI-396137,EBI-10329202 HEMK1  
  .DNA methylation .protein methyltransferase activity
.N-methyltransferase activity
.DNA binding
.mitochondrion
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland91
bladder267
blood32
bone55
bone marrow41
brain71
cervix123
connective tissue46
ear124
embryonic tissue108
esophagus49
eye19
heart11
intestine34
kidney56
liver24
lung41
lymph22
lymph node11
mammary gland39
mouth120
muscle122
nerve128
ovary78
pancreas51
pharynx24
pituitary gland60
placenta95
prostate26
salivary gland148
skin71
spleen93
stomach20
testis107
thymus200
thyroid85
trachea96
uterus60
vascular116
Health State
TissuesTPM*
normal66
adrenal tumor79
bladder carcinoma398
breast (mammary gland) tumor42
cervical tumor57
chondrosarcoma48
colorectal tumor8
esophageal tumor57
gastrointestinal tumor25
germ cell tumor129
glioma46
head and neck tumor59
kidney tumor43
leukemia31
lung tumor29
lymphoma13
non-neoplasia72
ovarian tumor91
primitive neuroectodermal tumor of the CNS94
prostate cancer28
retinoblastoma21
skin tumor71
soft tissue/muscle tissue tumor31
uterine tumor33
Developmental Stage
TissuesTPM*
adult62
embryoid body100
blastocyst146
neonate96
fetus77
infant42
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue11.5
adrenal gland12.6
appendix14.9
bone marrow11.8
cerebral cortex14.1
colon14.4
duodenum11.4
esophagus16.1
gallbladder12.9
heart muscle12.8
kidney16.4
liver9.3
lung13.4
lymph node19.4
ovary16.8
pancreas4.1
placenta24.6
prostate15
salivary gland9.5
skin15.7
small intestine11.4
spleen14.9
stomach12.5
testis16.4
thyroid gland19
urinary bladder17.5
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603462, gene) Cell division cycle 23; CDC23OMIM


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