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> Protein (NX_Q9UJY1)
Protein (NX_Q9UJY1)
Protein
Gene SymbolHSPB8 to neXtProt (NX_Q9UJY1)
DescriptionHeat shock protein beta-8
Chromosome12
Location12q24.23 (119616447 ~ 119658936) to Ensembl
Sequene Features : Isoforms 1, Variants 40, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.N/A .identical protein binding .Golgi apparatus
.cytoplasm
.nucleoplasm
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 40 4
2014-09-19protein level
1 27 4
2014-05-27protein level
1 27 4
2014-02-25protein level
1 27 3
2013-12-09protein level
1 24 3
2013-11-01protein level
1 20 3
2013-09-12protein level
1 20 3
2013-08-17protein level
1 20 3
2013-07-15protein level
1 18 3
2013-06-11protein level
1 18 3
2013-02-12protein level
1 9 4
2012-12-20protein level
1 9 4
2012-10-30protein level
1 8 4
2012-10-07protein level
1 8 4
2012-08-24protein level
1 8 4
2012-07-28protein level
1 8 4
2012-06-08protein level
1 9 4
2012-05-07protein level
1 8 4
2012-04-10protein level
1 8 4
2012-01-13protein level
1 9 4
2011-12-20protein level
1 9 4
2011-11-11protein level
1 9 3
2011-08-23protein level
1 9 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9UJY1-1
9 0 0 21590.5684
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-739074,EBI-739095 HSPB6  
  .regulation of muscle contraction .protein homodimerization activity
.structural constituent of eye lens
.cytoplasm
.nucleus
2 EBI-739074,EBI-747185 BAG3  
  .regulation of cellular response to heat
.extrinsic apoptotic signaling pathway in absence of ligand
.cellular response to mechanical stimulus
  + 8 more...
.N/A .neuron projection
.Z disc
.plasma membrane
  + 2 more...
3 EBI-739074,EBI-739060 CRYAB  
  .negative regulation of reactive oxygen species metabolic process
.cellular response to gamma radiation
.apoptotic process involved in morphogenesis
  + 18 more...
.unfolded protein binding
.metal ion binding
.protein homodimerization activity
  + 2 more...
.extracellular exosome
.actin filament bundle
.Z disc
  + 8 more...
4 EBI-739074,EBI-352682 HSPB1  
  .positive regulation of endothelial cell chemotaxis
.negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
.platelet aggregation
  + 17 more...
.poly(A) RNA binding
.ubiquitin binding
.identical protein binding
  + 3 more...
.extracellular exosome
.Z disc
.focal adhesion
  + 8 more...
5 EBI-739074,EBI-739395 HSPB2  
  .positive regulation of catalytic activity
.response to unfolded protein
.enzyme activator activity .cytosol
.cytoplasm
.nucleus
6 EBI-739074,EBI-2798044 QRICH1  
  .N/A .N/A .nucleoplasm
7 EBI-739074,EBI-739361 HSPB7  
  .regulation of heart contraction
.response to unfolded protein
.protein C-terminus binding .actin cytoskeleton
.Cajal body
.mitochondrion
  + 2 more...
8 EBI-739074,EBI-715161 DUSP12  
  .peptidyl-tyrosine dephosphorylation
.positive regulation of glucokinase activity
.protein dephosphorylation
.cellular protein modification process
.zinc ion binding
.protein tyrosine/serine/threonine phosphatase activity
.protein tyrosine phosphatase activity
.cytoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland60
bladder33
bone83
brain117
cervix123
connective tissue40
embryonic tissue28
esophagus99
eye186
heart379
intestine47
kidney75
liver4
lung20
lymph node11
mammary gland19
mouth120
muscle159
nerve257
ovary9
pancreas32
parathyroid339
pharynx24
placenta431
prostate26
salivary gland148
skin37
spleen56
stomach73
testis9
thyroid64
trachea19
umbilical cord145
uterus86
vascular58
Health State
TissuesTPM*
normal122
breast (mammary gland) tumor32
cervical tumor28
chondrosarcoma84
gastrointestinal tumor8
germ cell tumor15
glioma205
head and neck tumor59
kidney tumor101
lung tumor29
lymphoma13
non-neoplasia113
pancreatic tumor19
primitive neuroectodermal tumor of the CNS7
skin tumor31
soft tissue/muscle tissue tumor39
uterine tumor55
Developmental Stage
TissuesTPM*
adult128
embryoid body57
blastocyst32
neonate64
fetus64
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue37.5
adrenal gland13.7
appendix30.3
cerebral cortex56.7
colon32.3
duodenum7.4
esophagus146.8
gallbladder46
heart muscle297
kidney18.5
liver3.4
lung44.3
lymph node10.9
ovary7
pancreas13
placenta141.6
prostate114.8
salivary gland32.7
skin23.2
small intestine8.5
spleen48.4
stomach9
testis12.5
thyroid gland17.1
urinary bladder122.8
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
breastLow
bronchusMedium
cerebellumMedium
cerebral cortexHigh
cervix, uterineHigh
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusHigh
fallopian tubeMedium
gallbladderMedium
heart muscleMedium
hippocampusMedium
kidneyMedium
lateral ventricleMedium
liverLow
lungHigh
lymph nodeMedium
nasopharynxMedium
oral mucosaMedium
pancreasHigh
parathyroid glandMedium
placentaHigh
prostateLow
rectumLow
salivary glandMedium
seminal vesicleMedium
skeletal muscleMedium
skin 1High
skin 2High
small intestineMedium
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Medium
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderMedium
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#158590, phenotype) Neuronopathy, distal hereditary motor, type iia; HMN2AOMIM
2(*608014, gene) Heat-shock 22-kd protein 8; HSPB8OMIM
3(#608673, phenotype) Charcot-marie-tooth disease, axonal, type 2l; CMT2LOMIM


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