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> Protein (NX_Q9UKG1)
Protein (NX_Q9UKG1)
Protein
Gene SymbolAPPL1 to neXtProt (NX_Q9UKG1)
DescriptionDCC-interacting protein 13-alpha
Chromosome3
Location3p14.3 (57261765 ~ 57307496) to Ensembl
Sequene Features : Isoforms 1, Variants 86, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.extrinsic apoptotic signaling pathway in absence of ligand
.extrinsic apoptotic signaling pathway
.regulation of establishment of protein localization to plasma membrane
  + 7 more...
.protein kinase B binding
.identical protein binding
.extracellular exosome
.early endosome membrane
.vesicle membrane
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 86 6
2014-09-19protein level
1 61 6
2014-05-27protein level
1 61 6
2014-02-25protein level
1 61 6
2013-12-09protein level
1 45 6
2013-11-01protein level
1 43 4
2013-09-12protein level
1 43 4
2013-08-17protein level
1 43 4
2013-07-15protein level
1 31 3
2013-06-11protein level
1 31 3
2013-02-12protein level
1 18 4
2012-12-20protein level
1 17 4
2012-10-30protein level
1 20 4
2012-10-07protein level
1 20 4
2012-08-24protein level
1 19 4
2012-07-28protein level
1 19 4
2012-06-08protein level
1 21 4
2012-05-07protein level
1 14 3
2012-04-10protein level
1 14 3
2012-01-13protein level
1 7 3
2011-12-20protein level
1 7 3
2011-11-11protein level
1 7 3
2011-08-23protein level
1 7 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9UKG1-1
32 0 0 79613.3669
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-741243,EBI-607682 HDAC3  
  .cellular response to fluid shear stress
.spindle assembly
.neurotrophin TRK receptor signaling pathway
  + 21 more...
.NAD-dependent histone deacetylase activity (H3-K18 specific)
.NF-kappaB binding
.NAD-dependent histone deacetylase activity (H4-K16 specific)
  + 11 more...
.transcriptional repressor complex
.plasma membrane
.spindle microtubule
  + 5 more...
2 EBI-741243,EBI-2799016 DYSF  
  .vesicle fusion
.plasma membrane repair
.calcium-dependent phospholipid binding
.phospholipid binding
.calcium ion binding
.extracellular exosome
.sarcolemma
.cytoplasmic vesicle membrane
  + 8 more...
3 EBI-741243,EBI-2513774 FARS2  
  .gene expression
.tRNA processing
.phenylalanyl-tRNA aminoacylation
.tRNA aminoacylation for protein translation
.ATP binding
.phenylalanine-tRNA ligase activity
.magnesium ion binding
.tRNA binding
.mitochondrial matrix
.mitochondrion
4 EBI-741243,EBI-297353 EGFR  
  .cellular response to dexamethasone stimulus
.cellular response to estradiol stimulus
.cellular response to epidermal growth factor stimulus
  + 73 more...
.actin filament binding
.protein heterodimerization activity
.identical protein binding
  + 12 more...
.multivesicular body, internal vesicle lumen
.Shc-EGFR complex
.perinuclear region of cytoplasm
  + 19 more...
5 EBI-741243,EBI-399437 RAB5A  
  .regulation of synaptic vesicle exocytosis
.receptor internalization involved in canonical Wnt signaling pathway
.regulation of filopodium assembly
  + 12 more...
.GDP binding
.GTP binding
.GTPase activity
.cytoplasmic side of early endosome membrane
.extracellular exosome
.recycling endosome
  + 22 more...
6 EBI-741243,EBI-296087 AKT1  
  .negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.response to insulin-like growth factor stimulus
.negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
  + 108 more...
.14-3-3 protein binding
.phosphatidylinositol-3,4-bisphosphate binding
.identical protein binding
  + 8 more...
.ciliary basal body
.microtubule cytoskeleton
.cell-cell junction
  + 7 more...
7 EBI-741243,EBI-77797 ACTN2  
  .negative regulation of protein localization to cell surface
.positive regulation of potassium ion transmembrane transporter activity
.negative regulation of potassium ion transmembrane transporter activity
  + 13 more...
.titin Z domain binding
.FATZ binding
.protein dimerization activity
  + 8 more...
.extracellular exosome
.dendritic spine
.pseudopodium
  + 9 more...
8 EBI-741243,EBI-10209139 MAGEA9B  
  .N/A .N/A .N/A
9 EBI-741243,EBI-2864512 MEOX1  
  .sclerotome development
.somite development
.hematopoietic stem cell differentiation
  + 2 more...
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.chromatin binding
  + 3 more...
.cytoplasm
.nucleus
10 EBI-741243,EBI-310758 DST  
  .cell motility
.intermediate filament cytoskeleton organization
.hemidesmosome assembly
  + 8 more...
.microtubule plus-end binding
.protein homodimerization activity
.protein C-terminus binding
  + 2 more...
.extracellular exosome
.intermediate filament cytoskeleton
.microtubule plus-end
  + 19 more...
11 EBI-741243,EBI-355744 TRAF2  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.negative regulation of neuron death
  + 35 more...
.sphingolipid binding
.identical protein binding
.thioesterase binding
  + 10 more...
.IRE1-TRAF2-ASK1 complex
.TRAF2-GSTP1 complex
.membrane raft
  + 7 more...
12 EBI-741243,EBI-301834 HDAC1  
  .histone H4 deacetylation
.histone H3 deacetylation
.fungiform papilla formation
  + 34 more...
.NAD-dependent histone deacetylase activity (H3-K18 specific)
.repressing transcription factor binding
.NF-kappaB binding
  + 17 more...
.protein complex
.NuRD complex
.Sin3 complex
  + 7 more...
13 EBI-741243,EBI-1769445 ADIPOR2  
  .positive regulation of glucose import
.adiponectin-activated signaling pathway
.negative regulation of cell growth
  + 5 more...
.hormone binding
.receptor activity
.integral component of membrane
.plasma membrane
14 EBI-741243,EBI-741261 APPL2  
  .cell proliferation
.signal transduction
.cell cycle
.N/A .extracellular exosome
.early endosome membrane
.endosome membrane
  + 2 more...
15 EBI-741243,EBI-746555 RHEBL1  
  .positive regulation of NF-kappaB transcription factor activity
.TOR signaling
.small GTPase mediated signal transduction
.metal ion binding
.GTP binding
.membrane
.endomembrane system
.cytoplasm
16 EBI-741243,EBI-2372294 SYNE2  
  .cytoskeletal anchoring at nuclear membrane
.centrosome localization
.protein localization to nucleus
  + 6 more...
.actin binding .extracellular exosome
.intermediate filament cytoskeleton
.LINC complex
  + 16 more...
17 EBI-741243,EBI-1632076 ADIPOR1  
  .positive regulation of insulin receptor signaling pathway
.positive regulation of JAK-STAT cascade
.adiponectin-activated signaling pathway
  + 4 more...
.hormone binding
.protein kinase binding
.receptor activity
.integral component of membrane
.membrane
.plasma membrane
18 EBI-741243,EBI-2339946 UBE2O  
  .protein K63-linked ubiquitination
.retrograde transport, endosome to Golgi
.positive regulation of BMP signaling pathway
.protein monoubiquitination
.ubiquitin conjugating enzyme activity
.ubiquitin protein ligase activity
.poly(A) RNA binding
  + 5 more...
.cytoplasm
.nucleoplasm
.nucleus
19 EBI-741243,EBI-1056039 RAB21  
  .positive regulation of early endosome to late endosome transport
.positive regulation of receptor-mediated endocytosis
.Rab protein signal transduction
  + 3 more...
.GDP binding
.GTP binding
.GTPase activity
.cytoplasmic side of early endosome membrane
.extracellular exosome
.Golgi cisterna membrane
  + 8 more...
20 EBI-741243,EBI-2107208 RTCB  
  .tRNA splicing, via endonucleolytic cleavage and ligation
.placenta development
.in utero embryonic development
.metal ion binding
.poly(A) RNA binding
.vinculin binding
  + 2 more...
.tRNA-splicing ligase complex
.endoplasmic reticulum membrane
.cytoplasm
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland60
ascites25
blood73
bone69
bone marrow41
brain39
cervix41
connective tissue60
ear248
embryonic tissue42
eye33
heart89
intestine34
kidney37
liver14
lung38
lymph node144
mammary gland39
mouth45
muscle56
ovary39
pancreas60
pharynx122
placenta42
prostate63
salivary gland49
skin52
spleen18
testis55
thymus37
thyroid42
trachea115
umbilical cord72
uterus60
vascular38
Health State
TissuesTPM*
normal45
breast (mammary gland) tumor64
cervical tumor57
chondrosarcoma60
colorectal tumor26
gastrointestinal tumor8
germ cell tumor53
glioma83
head and neck tumor37
kidney tumor29
leukemia74
liver tumor10
lung tumor9
lymphoma27
non-neoplasia31
ovarian tumor65
pancreatic tumor66
primitive neuroectodermal tumor of the CNS23
prostate cancer67
retinoblastoma21
skin tumor39
soft tissue/muscle tissue tumor71
uterine tumor55
Developmental Stage
TissuesTPM*
adult41
embryoid body71
blastocyst16
neonate32
fetus46
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue15.1
adrenal gland14.2
appendix19
bone marrow17.5
cerebral cortex19.1
colon17.4
duodenum13.8
esophagus23.1
gallbladder17.9
heart muscle21.7
kidney16.6
liver8
lung14.9
lymph node19
ovary24.5
pancreas19
placenta13.8
prostate16.1
salivary gland14.2
skin18.5
small intestine15.4
spleen16.4
stomach17.3
testis15
thyroid gland24
urinary bladder21
Tissues
TissuesExpression level
adrenal glandLow
appendixMedium
bone marrowLow
breastMedium
bronchusLow
cerebellumMedium
cerebral cortexMedium
cervix, uterineLow
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
fallopian tubeMedium
gallbladderMedium
hippocampusMedium
kidneyMedium
lateral ventricleLow
lungLow
lymph nodeHigh
nasopharynxMedium
oral mucosaLow
ovaryMedium
pancreasMedium
parathyroid glandLow
placentaMedium
prostateLow
rectumMedium
salivary glandMedium
seminal vesicleMedium
skin 1Medium
skin 2Medium
small intestineLow
spleenMedium
stomach 1Medium
stomach 2Medium
testisLow
thyroid glandLow
tonsilHigh
urinary bladderLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604299, gene) Adaptor protein, phosphotyrosine interaction, ph domain, and leucineOMIM


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