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> Protein (NX_Q9UKS6)
Protein (NX_Q9UKS6)
Protein
Gene SymbolPACSIN3 to neXtProt (NX_Q9UKS6)
DescriptionProtein kinase C and casein kinase substrate in neurons protein 3
Chromosome11
Location11p11.2 (47199076 ~ 47207994) to Ensembl
Sequene Features : Isoforms 1, Variants 55, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.membrane tubulation
.negative regulation of calcium ion transport
.positive regulation of membrane protein ectodomain proteolysis
  + 4 more...
.calcium channel inhibitor activity
.lipid binding
.cytoskeletal protein binding
.phospholipid binding
.extracellular exosome
.membrane-bounded vesicle
.membrane
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 55 7
2014-09-19protein level
1 48 7
2014-05-27protein level
1 48 7
2014-02-25protein level
1 49 7
2013-12-09protein level
1 31 7
2013-11-01protein level
1 29 7
2013-09-12protein level
1 29 7
2013-08-17protein level
1 29 7
2013-07-15protein level
1 22 7
2013-06-11protein level
1 22 7
2013-02-12protein level
1 14 7
2012-12-20protein level
1 14 7
2012-10-30protein level
1 17 7
2012-10-07protein level
1 17 7
2012-08-24protein level
1 16 7
2012-07-28protein level
1 16 7
2012-06-08protein level
1 16 7
2012-05-07protein level
1 16 7
2012-04-10protein level
1 16 7
2012-01-13protein level
1 10 7
2011-12-20protein level
1 10 7
2011-11-11protein level
1 10 7
2011-08-23protein level
1 10 7
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9UKS6-1
19 0 0 48456.6901
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-77926,EBI-742487 SPRY2  
  .positive regulation of protein serine/threonine kinase activity
.positive regulation of ERK1 and ERK2 cascade
.negative regulation of ERK1 and ERK2 cascade
  + 19 more...
.protein serine/threonine kinase activator activity
.protein serine/threonine kinase inhibitor activity
.protein kinase binding
.ruffle membrane
.microtubule cytoskeleton
.plasma membrane
  + 2 more...
2 EBI-77926,EBI-495538 FASLG  
  .positive regulation of endothelial cell apoptotic process
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.necroptotic signaling pathway
  + 30 more...
.receptor binding .extracellular exosome
.cytoplasmic membrane-bounded vesicle lumen
.perinuclear region of cytoplasm
  + 8 more...
3 EBI-77926,EBI-297487 SOS1  
  .apoptotic signaling pathway
.positive regulation of small GTPase mediated signal transduction
.regulation of small GTPase mediated signal transduction
  + 16 more...
.GTPase activator activity
.Rho guanyl-nucleotide exchange factor activity
.Ras guanyl-nucleotide exchange factor activity
.DNA binding
.neuronal cell body
.postsynaptic density
.plasma membrane
.cytosol
4 EBI-77926,EBI-298181 SOS2  
  .apoptotic signaling pathway
.positive regulation of small GTPase mediated signal transduction
.regulation of small GTPase mediated signal transduction
  + 4 more...
.Rho guanyl-nucleotide exchange factor activity
.DNA binding
.cytosol
5 EBI-77926,EBI-77903 ADAM9  
  .cellular response to lipopolysaccharide
.response to calcium ion
.positive regulation of keratinocyte migration
  + 23 more...
.laminin binding
.SH3 domain binding
.zinc ion binding
  + 5 more...
.extracellular exosome
.intrinsic component of external side of plasma membrane
.basolateral plasma membrane
  + 5 more...
6 EBI-77926,EBI-77818 ADAM15  
  .negative regulation of receptor binding
.protein kinase C signaling
.cardiac epithelial to mesenchymal transition
  + 11 more...
.SH3 domain binding
.zinc ion binding
.metallopeptidase activity
  + 2 more...
.extracellular exosome
.cell projection
.integral component of membrane
  + 4 more...
7 EBI-77926,EBI-721769 PACSIN1  
  .positive regulation of dendrite development
.membrane tubulation
.establishment of protein localization to plasma membrane
  + 7 more...
.cytoskeletal protein binding
.phospholipid binding
.perinuclear region of cytoplasm
.synapse
.axon terminus
  + 11 more...
8 EBI-77926,EBI-3957707 LGALS13  
  .positive regulation of T cell apoptotic process
.apoptotic process
.phospholipid metabolic process
.carbohydrate binding
.lysophospholipase activity
.N/A
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
ascites100
blood8
bone13
brain16
cervix206
connective tissue20
embryonic tissue37
esophagus99
eye47
heart22
intestine38
kidney18
liver24
lung29
mammary gland39
muscle159
ovary29
pancreas28
pharynx24
placenta74
prostate42
salivary gland49
skin33
stomach41
testis11
uterus38
Health State
TissuesTPM*
normal27
breast (mammary gland) tumor53
cervical tumor144
chondrosarcoma48
colorectal tumor17
esophageal tumor115
gastrointestinal tumor50
germ cell tumor30
glioma37
head and neck tumor14
kidney tumor29
leukemia10
liver tumor20
lung tumor29
ovarian tumor13
pancreatic tumor38
primitive neuroectodermal tumor of the CNS62
prostate cancer57
retinoblastoma64
skin tumor55
soft tissue/muscle tissue tumor47
uterine tumor66
Developmental Stage
TissuesTPM*
adult35
embryoid body28
blastocyst81
fetus10
infant42
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue6.3
adrenal gland42.1
appendix3.6
cerebral cortex6.7
colon4.6
duodenum3.1
esophagus31.5
gallbladder7.4
heart muscle95.9
kidney11.8
liver11.1
lung12.6
lymph node1.7
ovary15.3
pancreas10.4
placenta15.8
prostate32.2
salivary gland23.3
skin23.2
small intestine3.8
spleen3.6
stomach10.8
testis3.6
thyroid gland13.1
urinary bladder9.8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*606513, gene) Protein kinase c and casein kinase substrate in neurons 3; PACSIN3OMIM


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