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> Protein (NX_Q9UKS7)
Protein (NX_Q9UKS7)
Protein
Gene SymbolIKZF2 to neXtProt (NX_Q9UKS7)
DescriptionZinc finger protein Helios
Chromosome2
Location2q34 (213864429 ~ 214017151) to Ensembl
Sequene Features : Isoforms 8, Variants 93, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of transcription from RNA polymerase II promoter
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
8 93 6
2014-09-19protein level
8 66 6
2014-05-27protein level
2 64 6
2014-02-25protein level
2 64 6
2013-12-09protein level
2 52 6
2013-11-01protein level
2 48 6
2013-09-12protein level
2 48 6
2013-08-17protein level
2 48 6
2013-07-15protein level
2 24 4
2013-06-11protein level
2 24 4
2013-02-12protein level
2 11 12
2012-12-20protein level
2 12 12
2012-10-30protein level
2 17 12
2012-10-07protein level
2 17 6
2012-08-24protein level
2 12 6
2012-07-28protein level
2 12 6
2012-06-08protein level
2 14 6
2012-05-07protein level
2 14 6
2012-04-10protein level
2 14 6
2012-01-13protein level
2 10 6
2011-12-20protein level
2 10 6
2011-11-11protein level
2 10 6
2011-08-23protein level
2 10 6
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9UKS7-1
0 15 6 59535.2582
NX_Q9UKS7-2
0 16 4 56728.8614
NX_Q9UKS7-3
1 5 1 16236.5792
NX_Q9UKS7-4
1 14 4 51320.1374
NX_Q9UKS7-5
1 1 0 5721.556
NX_Q9UKS7-6
1 6 5 26784.5406
NX_Q9UKS7-7
1 15 3 51391.4005
NX_Q9UKS7-8
1 6 1 25962.1332
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-3893057,EBI-745213 AQP1  
  .cation transmembrane transport
.maintenance of symbiont-containing vacuole by host
.ammonium transmembrane transport
  + 60 more...
.carbon dioxide transmembrane transporter activity
.nitric oxide transmembrane transporter activity
.transmembrane transporter activity
  + 8 more...
.extracellular exosome
.apical part of cell
.axon terminus
  + 12 more...
2 EBI-3893057,EBI-741533 CTBP2  
  .white fat cell differentiation
.positive regulation of retinoic acid receptor signaling pathway
.positive regulation of transcription from RNA polymerase II promoter
  + 5 more...
.NAD binding
.oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
.transcription corepressor activity
  + 2 more...
.synapse
.cell junction
.transcriptional repressor complex
.nucleus
3 EBI-3893057,EBI-2341787 LONRF1  
  .N/A .zinc ion binding
.ATP-dependent peptidase activity
.N/A
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder66
blood8
brain3
connective tissue6
embryonic tissue9
eye14
heart22
kidney4
lung20
lymph node22
mouth60
muscle28
pancreas18
pharynx49
placenta3
prostate15
spleen18
testis9
thymus62
thyroid85
trachea38
uterus4
Health State
TissuesTPM*
normal9
bladder carcinoma113
germ cell tumor26
head and neck tumor52
leukemia42
non-neoplasia10
primitive neuroectodermal tumor of the CNS7
prostate cancer9
soft tissue/muscle tissue tumor7
uterine tumor11
Developmental Stage
TissuesTPM*
adult7
embryoid body28
fetus17
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue1.3
adrenal gland2
appendix3.4
bone marrow3.8
cerebral cortex1.9
colon2
esophagus25.1
gallbladder3.6
heart muscle1.2
kidney1.7
liver1.2
lung3
lymph node7
ovary2
placenta3
prostate3.7
salivary gland2.8
skin7.6
small intestine1.1
spleen5.5
stomach4.6
testis2.2
thyroid gland7.9
urinary bladder14.9
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*606234, gene) Ikaros family zinc finger 2; IKZF2OMIM


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