Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_Q9UKT9)
Protein (NX_Q9UKT9)
Protein
Gene SymbolIKZF3 to neXtProt (NX_Q9UKT9)
DescriptionZinc finger protein Aiolos
Chromosome17
Location17q12 (37921198 ~ 38020441) to Ensembl
Sequene Features : Isoforms 16, Variants 94, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of lymphocyte differentiation
.regulation of B cell differentiation
.regulation of apoptotic process
  + 5 more...
.protein heterodimerization activity
.metal ion binding
.sequence-specific DNA binding
  + 2 more...
.plasma membrane
.cytoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
16 94 0
2014-09-19protein level
16 63 0
2014-05-27protein level
15 63 1
2014-02-25protein level
15 62 1
2013-12-09protein level
15 49 1
2013-11-01protein level
15 47 1
2013-09-12protein level
15 47 1
2013-08-17protein level
15 47 1
2013-07-15protein level
15 38 0
2013-06-11protein level
15 38 0
2013-02-12protein level
15 17 36
2012-12-20protein level
15 19 36
2012-10-30protein level
15 20 36
2012-10-07protein level
15 20 3
2012-08-24protein level
15 10 3
2012-07-28protein level
15 10 3
2012-06-08protein level
15 7 3
2012-05-07protein level
15 7 3
2012-04-10protein level
15 7 3
2012-01-13protein level
15 7 3
2011-12-20protein level
15 13 3
2011-11-11protein level
15 13 3
2011-08-23protein level
15 13 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9UKT9-1
0 21 3 57985.6165
NX_Q9UKT9-10
1 14 0 41539.8831
NX_Q9UKT9-11
1 13 0 36920.7216
NX_Q9UKT9-12
1 13 0 32643.4344
NX_Q9UKT9-13
0 18 0 42702.0493
NX_Q9UKT9-14
0 11 3 30010.0535
NX_Q9UKT9-15
0 21 0 51846.5868
NX_Q9UKT9-16
0 11 0 29953.5611
NX_Q9UKT9-2
0 20 0 51598.498
NX_Q9UKT9-3
0 20 3 53366.455
NX_Q9UKT9-4
1 20 3 53708.3293
NX_Q9UKT9-5
1 18 0 46979.3365
NX_Q9UKT9-6
0 19 3 49089.1678
NX_Q9UKT9-7
0 20 3 54382.0829
NX_Q9UKT9-8
0 19 3 49762.9214
NX_Q9UKT9-9
1 16 2 47927.0016
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-747204,EBI-346930 PIK3R2  
  .regulation of small GTPase mediated signal transduction
.leukocyte migration
.T cell receptor signaling pathway
  + 25 more...
.protein heterodimerization activity
.1-phosphatidylinositol-3-kinase regulator activity
.receptor tyrosine kinase binding
.protein phosphatase binding
.phosphatidylinositol 3-kinase complex
.cytosol
.nucleus
2 EBI-747204,EBI-1055079 POLR1C  
  .negative regulation of gene expression, epigenetic
.innate immune response
.regulation of gene expression, epigenetic
  + 9 more...
.DNA-directed RNA polymerase activity
.DNA binding
.cytosol
.DNA-directed RNA polymerase I complex
.DNA-directed RNA polymerase III complex
.nucleoplasm
3 EBI-747204,EBI-1053424 PRKAB2  
  .membrane organization
.regulation of protein kinase activity
.small molecule metabolic process
  + 13 more...
.identical protein binding .AMP-activated protein kinase complex
.cytosol
.nucleoplasm
4 EBI-747204,EBI-714135 STX11  
  .membrane fusion
.vesicle docking
.natural killer cell degranulation
  + 4 more...
.SNAP receptor activity
.SNARE binding
.SNARE complex
.integral component of membrane
.endomembrane system
  + 3 more...
5 EBI-747204,EBI-749295 STK16  
  .cellular response to transforming growth factor beta stimulus
.protein autophosphorylation
.regulation of signal transduction
.ATP binding
.non-membrane spanning protein tyrosine kinase activity
.protein serine/threonine kinase activity
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.perinuclear region of cytoplasm
.membrane
.Golgi-associated vesicle
.cytoplasm
6 EBI-747204,EBI-1055693 RAD51D  
  .strand invasion
.reciprocal meiotic recombination
.DNA repair
  + 2 more...
.gamma-tubulin binding
.DNA-dependent ATPase activity
.ATP binding
  + 2 more...
.Rad51B-Rad51C-Rad51D-XRCC2 complex
.centrosome
.cytoplasm
  + 3 more...
7 EBI-747204,EBI-743573 TRAPPC6A  
  .vesicle-mediated transport .N/A .Golgi apparatus
.endoplasmic reticulum
8 EBI-747204,EBI-1050106 BCAS2  
  .gene expression
.RNA splicing
.mRNA splicing, via spliceosome
.RNA splicing, via transesterification reactions
.N/A .cell junction
.nucleolus
.spliceosomal complex
  + 2 more...
9 EBI-747204,EBI-351267 ABLIM3  
  .positive regulation of protein targeting to mitochondrion
.positive regulation of transcription from RNA polymerase II promoter
.cilium assembly
  + 4 more...
.zinc ion binding .lamellipodium
.cytoplasm
.stress fiber
10 EBI-747204,EBI-2513774 FARS2  
  .gene expression
.tRNA processing
.phenylalanyl-tRNA aminoacylation
.tRNA aminoacylation for protein translation
.ATP binding
.phenylalanine-tRNA ligase activity
.magnesium ion binding
.tRNA binding
.mitochondrial matrix
.mitochondrion
11 EBI-747204,EBI-742756 KRT19  
  .cell differentiation involved in embryonic placenta development
.sarcomere organization
.response to estrogen
.viral process
.structural constituent of muscle
.structural constituent of cytoskeleton
.cell periphery
.extracellular exosome
.costamere
  + 5 more...
12 EBI-747204,EBI-359352 PSMA1  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 23 more...
.threonine-type endopeptidase activity
.endopeptidase activity
.RNA binding
.extracellular exosome
.proteasome core complex, alpha-subunit complex
.polysome
  + 7 more...
13 EBI-747204,EBI-739696 LMO2  
  .cellular response to thyroid hormone stimulus
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of erythrocyte differentiation
  + 3 more...
.E-box binding
.cofactor binding
.bHLH transcription factor binding
  + 7 more...
.transcription factor complex
.nucleus
14 EBI-747204,EBI-8639312 LMO1  
  .positive regulation of transcription from RNA polymerase II promoter
.negative regulation of transcription from RNA polymerase II promoter
.zinc ion binding .nucleus
15 EBI-747204,EBI-745213 AQP1  
  .cation transmembrane transport
.maintenance of symbiont-containing vacuole by host
.ammonium transmembrane transport
  + 60 more...
.carbon dioxide transmembrane transporter activity
.nitric oxide transmembrane transporter activity
.transmembrane transporter activity
  + 8 more...
.extracellular exosome
.apical part of cell
.axon terminus
  + 12 more...
16 EBI-747204,EBI-375077 CDKN1A  
  .positive regulation of reactive oxygen species metabolic process
.regulation of DNA biosynthetic process
.negative regulation of G1/S transition of mitotic cell cycle
  + 44 more...
.metal ion binding
.ubiquitin protein ligase binding
.cyclin-dependent protein kinase activating kinase activity
.cyclin-dependent protein serine/threonine kinase inhibitor activity
.PCNA-p21 complex
.perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
  + 4 more...
17 EBI-747204,EBI-352986 HNRNPF  
  .regulation of RNA splicing
.gene expression
.RNA splicing
  + 2 more...
.poly(A) RNA binding
.single-stranded RNA binding
.RNA binding
.nucleotide binding
.catalytic step 2 spliceosome
.membrane
.nucleoplasm
.nucleus
18 EBI-747204,EBI-744104 GEM  
  .metaphase plate congression
.chromosome organization
.metabolic process
  + 5 more...
.GDP binding
.GTP binding
.GTPase activity
.magnesium ion binding
.mitotic spindle
.spindle midzone
.midbody
  + 2 more...
19 EBI-747204,EBI-745859 CDKN2D  
  .negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
.negative regulation of protein serine/threonine kinase activity
.autophagic cell death
  + 13 more...
.protein kinase binding
.cyclin-dependent protein serine/threonine kinase inhibitor activity
.cytosol
.cytoplasm
.nucleus
20 EBI-747204,EBI-446668 RHOA  
  .skeletal muscle satellite cell migration
.mitotic spindle assembly
.trabecula morphogenesis
  + 32 more...
.myosin binding
.GTP binding
.GTPase activity
.extracellular exosome
.apical junction complex
.cleavage furrow
  + 11 more...
21 EBI-747204,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
22 EBI-747204,EBI-717810 AES  
  .positive regulation of anoikis
.negative regulation of canonical Wnt signaling pathway
.response to interleukin-1
  + 12 more...
.transcription corepressor activity .nucleus
23 EBI-747204,EBI-723426 MRPL28  
  .mitochondrial translational termination
.mitochondrial translational elongation
.mitochondrial translational initiation
  + 3 more...
.poly(A) RNA binding
.structural constituent of ribosome
.mitochondrial ribosome
.mitochondrial inner membrane
.mitochondrion
  + 2 more...
24 EBI-747204,EBI-1181405 PRKAA1  
  .negative regulation of glucose import in response to insulin stimulus
.regulation of energy homeostasis
.response to camptothecin
  + 42 more...
.[acetyl-CoA carboxylase] kinase activity
.tau-protein kinase activity
.[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
  + 7 more...
.AMP-activated protein kinase complex
.apical plasma membrane
.cytosol
  + 4 more...
25 EBI-747204,EBI-714158 PIN1  
  .negative regulation of cell motility
.negative regulation of ERK1 and ERK2 cascade
.regulation of pathway-restricted SMAD protein phosphorylation
  + 11 more...
.phosphothreonine binding
.phosphoserine binding
.GTPase activating protein binding
  + 2 more...
.midbody
.nuclear speck
.cytoplasm
  + 2 more...
26 EBI-747204,EBI-359031 EMC2  
  .N/A .N/A .ER membrane protein complex
.endoplasmic reticulum
.mitochondrion
  + 2 more...
27 EBI-747204,EBI-1051701 PCID2  
  .negative regulation of cysteine-type endopeptidase activity
.positive regulation of mitotic cell cycle spindle assembly checkpoint
.spleen development
  + 4 more...
.N/A .N/A
28 EBI-747204,EBI-743105 EFHC1  
  .cerebral cortex cell migration .protein C-terminus binding
.calcium ion binding
.mitotic spindle
.neuronal cell body
.axoneme
.centrosome
29 EBI-747204,EBI-8994397 TSTD2  
  .N/A .N/A .N/A
30 EBI-747204,EBI-9675802 MORN3  
  .N/A .N/A .nucleus
31 EBI-747204,EBI-742102 EXOC8  
  .membrane organization
.exocyst localization
.cellular protein metabolic process
  + 5 more...
.Ral GTPase binding .growth cone
.membrane
.plasma membrane
  + 4 more...
32 EBI-747204,EBI-3439227 ZGPAT  
  .negative regulation of transcription, DNA-templated
.negative regulation of epidermal growth factor-activated receptor activity
.negative regulation of transcription from RNA polymerase II promoter
.metal ion binding
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
  + 2 more...
.nucleus
33 EBI-747204,EBI-1166928 ATPAF2  
  .proton-transporting ATP synthase complex assembly .N/A .nuclear speck
.mitochondrion
34 EBI-747204,EBI-8656665 NATD1  
  .N/A .N/A .N/A
35 EBI-747204,EBI-10274069 LGALS14  
  .positive regulation of T cell apoptotic process
.apoptotic process
.carbohydrate binding .nucleus
36 EBI-747204,EBI-10244131 FBF1  
  .establishment of epithelial cell polarity
.apical junction assembly
.cilium assembly
.organelle organization
.N/A .ciliary transition fiber
.cell junction
.cytosol
  + 3 more...
37 EBI-747204,EBI-750487 TEKT4  
  .cell projection organization .N/A .motile cilium
.microtubule
.cytoplasm
.nucleus
38 EBI-747204,EBI-488533 ING5  
  .positive regulation of apoptotic signaling pathway
.negative regulation of growth
.positive regulation of transcription, DNA-templated
  + 7 more...
.methylated histone binding
.zinc ion binding
.chromatin binding
.MOZ/MORF histone acetyltransferase complex
.nucleoplasm
.nucleus
39 EBI-747204,EBI-399080 KAT5  
  .positive regulation of protein acetylation
.cellular response to estradiol stimulus
.positive regulation of transcription from RNA polymerase II promoter
  + 14 more...
.repressing transcription factor binding
.androgen receptor binding
.metal ion binding
  + 2 more...
.perinuclear region of cytoplasm
.NuA4 histone acetyltransferase complex
.Piccolo NuA4 histone acetyltransferase complex
  + 6 more...
40 EBI-747204,EBI-746778 MAGOHB  
  .mRNA transport
.RNA splicing
.mRNA processing
.poly(A) RNA binding .catalytic step 2 spliceosome
.exon-exon junction complex
41 EBI-747204,EBI-2513715 MRPL53  
  .mitochondrial translational termination
.mitochondrial translational elongation
.mitochondrial translational initiation
  + 2 more...
.N/A .ribosome
.mitochondrial inner membrane
42 EBI-747204,EBI-745021 STAMBPL1  
  .N/A .metal ion binding
.metallopeptidase activity
.membrane
43 EBI-747204,EBI-3918381 TSSK3  
  .intracellular signal transduction
.cell differentiation
.regulation of signal transduction
  + 3 more...
.ATP binding
.protein serine/threonine kinase activity
.magnesium ion binding
.cytoplasm
.nucleus
44 EBI-747204,EBI-10293968 PPP1R16B  
  .positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
.negative regulation of peptidyl-serine dephosphorylation
.establishment of endothelial barrier
  + 6 more...
.protein phosphatase type 1 regulator activity .perinuclear region of cytoplasm
.cell projection
.plasma membrane
.nucleus
45 EBI-747204,EBI-357275 PFDN5  
  .negative regulation of canonical Wnt signaling pathway
.retina development in camera-type eye
.'de novo' posttranslational protein folding
  + 4 more...
.transcription corepressor activity .prefoldin complex
.cytoplasm
.nucleus
46 EBI-747204,EBI-9641546 AKAP9  
  .positive regulation of potassium ion transmembrane transporter activity
.regulation of heart rate by cardiac conduction
.cellular response to cAMP
  + 11 more...
.ion channel binding
.protein complex scaffold
.potassium channel regulator activity
.receptor binding
.intracellular membrane-bounded organelle
.ciliary basal body
.voltage-gated potassium channel complex
  + 5 more...
47 EBI-747204,EBI-983719 FOXP3  
  .negative regulation of T-helper 17 cell differentiation
.T cell receptor signaling pathway
.negative regulation of immune response
  + 48 more...
.NFAT protein binding
.NF-kappaB binding
.metal ion binding
  + 9 more...
.protein complex
.cytoplasm
.nucleus
48 EBI-747204,EBI-742909 ARMC7  
  .N/A .N/A .cytoplasm
.nucleus
49 EBI-747204,EBI-740364 NEK6  
  .regulation of cellular senescence
.spindle assembly
.protein autophosphorylation
  + 13 more...
.protein kinase binding
.kinesin binding
.ATP binding
  + 3 more...
.nuclear speck
.microtubule
.cytosol
  + 4 more...
50 EBI-747204,EBI-371876 EXOSC5  
  .RNA phosphodiester bond hydrolysis, exonucleolytic
.polyadenylation-dependent snoRNA 3'-end processing
.nuclear mRNA surveillance
  + 10 more...
.RNA binding
.3'-5'-exoribonuclease activity
.transcriptionally active chromatin
.cytosol
.cytoplasm
  + 5 more...
51 EBI-747204,EBI-8787464 TBC1D22B  
  .N/A .GTPase activator activity .N/A
52 EBI-747204,EBI-2339898 FANCL  
  .regulation of cell proliferation
.gamete generation
.cellular response to DNA damage stimulus
  + 3 more...
.ubiquitin protein ligase activity
.ubiquitin protein ligase binding
.ligase activity
  + 2 more...
.Fanconi anaemia nuclear complex
.cytoplasm
.nucleoplasm
.nuclear envelope
53 EBI-747204,EBI-8643161 C1orf109  
  .N/A .N/A .N/A
54 EBI-747204,EBI-742688 SPG21  
  .antigen receptor-mediated signaling pathway .CD4 receptor binding .trans-Golgi network transport vesicle
.endosome membrane
.cytosol
  + 3 more...
55 EBI-747204,EBI-743428 RCOR3  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.chromatin binding
.DNA binding
.nucleus
56 EBI-747204,EBI-9057006 OSGIN1  
  .positive regulation of apoptotic process
.negative regulation of cell growth
.cell differentiation
.multicellular organismal development
.growth factor activity .N/A
57 EBI-747204,EBI-10281601 OAZ3  
  .negative regulation of polyamine transmembrane transport
.positive regulation of protein catabolic process
.small molecule metabolic process
  + 6 more...
.putrescine transmembrane transporter activity
.ornithine decarboxylase inhibitor activity
.blood microparticle
.sperm flagellum
.cytosol
.nucleus
58 EBI-747204,EBI-750484 FAM115A  
  .positive regulation of anion channel activity
.positive regulation of protein targeting to membrane
.negative regulation of cell migration
.transport
.ion channel binding .plasma membrane
59 EBI-747204,EBI-2321769 CHCHD2  
  .regulation of cellular response to hypoxia
.positive regulation of transcription from RNA polymerase II promoter
.transcription, DNA-templated
.sequence-specific DNA binding
.transcription factor binding
.mitochondrion
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood40
brain2
eye4
intestine4
kidney18
lung8
lymph135
lymph node334
mammary gland26
muscle9
ovary39
pancreas4
pharynx171
skin4
spleen112
testis4
thymus112
tonsil176
trachea38
uterus12
Health State
TissuesTPM*
normal19
breast (mammary gland) tumor10
germ cell tumor37
leukemia52
lymphoma124
non-neoplasia41
ovarian tumor52
pancreatic tumor9
retinoblastoma21
skin tumor7
soft tissue/muscle tissue tumor7
uterine tumor22
Developmental Stage
TissuesTPM*
adult11
fetus16
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
appendix19.3
bone marrow3.2
colon3.4
duodenum2.8
esophagus1.5
gallbladder3.2
lung2.6
lymph node31.7
salivary gland1.3
small intestine4.2
spleen21.3
stomach6.5
testis1.8
urinary bladder6.8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*606221, gene) Ikaros family zinc finger 3; IKZF3OMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center