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> Protein (NX_Q9UKV8)
Protein (NX_Q9UKV8)
Protein
Gene SymbolAGO2 to neXtProt (NX_Q9UKV8)
DescriptionProtein argonaute-2
Chromosome8
Location8q24.3 (141541264 ~ 141645718) to Ensembl
Sequene Features : Isoforms 2, Variants 1, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.mRNA cleavage involved in gene silencing by siRNA
.RNA phosphodiester bond hydrolysis, endonucleolytic
  + 25 more...
.endoribonuclease activity, cleaving miRNA-paired mRNA
.pre-miRNA binding
.endoribonuclease activity, cleaving siRNA-paired mRNA
  + 12 more...
.RISC-loading complex
.micro-ribonucleoprotein complex
.ribonucleoprotein complex
  + 9 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 1 4
2014-09-19protein level
2 51 4
2014-05-27protein level
2 51 4
2014-02-25protein level
2 51 4
2013-12-09protein level
2 50 4
2013-11-01protein level
2 47 4
2013-09-12protein level
2 47 4
2013-08-17protein level
2 47 4
2013-07-15protein level
2 29 3
2013-06-11protein level
2 29 3
2013-02-12protein level
2 4 4
2012-12-20protein level
2 4 4
2012-10-30protein level
2 4 4
2012-10-07protein level
2 4 2
2012-08-24protein level
2 0 2
2012-07-28protein level
2 0 2
2012-06-08protein level
2 24 2
2012-05-07protein level
2 34 2
2012-04-10protein level
2 34 2
2012-01-13protein level
2 27 2
2011-12-20protein level
2 27 2
2011-11-11protein level
2 27 2
2011-08-23protein level
2 27 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9UKV8-1
2 32 9 97145.6008
NX_Q9UKV8-2
1 32 9 93559.8545
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-528269,EBI-359969 TBKBP1  
  .innate immune response .N/A .N/A
2 EBI-528269,EBI-358808 IPO8  
  .gene expression
.signal transduction
.intracellular protein transport
.Ran GTPase binding .cytosol
.nucleoplasm
3 EBI-528269,EBI-296739 GNB2L1  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of gastrulation
.regulation of establishment of cell polarity
  + 30 more...
.poly(A) RNA binding
.protein homodimerization activity
.SH2 domain binding
  + 10 more...
.IRE1-RACK1-PP2A complex
.extracellular exosome
.perinuclear region of cytoplasm
  + 11 more...
4 EBI-528269,EBI-1047444 FKBP4  
  .regulation of cellular response to heat
.chaperone-mediated protein folding
.male sex differentiation
  + 12 more...
.poly(A) RNA binding
.heat shock protein binding
.protein binding, bridging
  + 4 more...
.extracellular exosome
.perinuclear region of cytoplasm
.axonal growth cone
  + 7 more...
5 EBI-528269,EBI-74090 EIF4EBP1  
  .negative regulation of translational initiation
.positive regulation of mitotic cell cycle
.response to ethanol
  + 11 more...
.translation repressor activity
.eukaryotic initiation factor 4E binding
.protein complex
.cytosol
.cytoplasm
.nucleoplasm
6 EBI-528269,EBI-1049387 PTGES3  
  .regulation of cellular response to heat
.chaperone cofactor-dependent protein refolding
.small molecule metabolic process
  + 7 more...
.unfolded protein binding
.prostaglandin-E synthase activity
.telomerase activity
.extracellular exosome
.cytosol
.cytoplasm
  + 4 more...
7 EBI-528269,EBI-978581 TARBP2  
  .negative regulation of defense response to virus by host
.regulation of viral transcription
.positive regulation of viral genome replication
  + 8 more...
.pre-miRNA binding
.protein homodimerization activity
.miRNA binding
  + 3 more...
.RISC-loading complex
.perinuclear region of cytoplasm
.micro-ribonucleoprotein complex
  + 5 more...
8 EBI-528269,EBI-5323863 LRRK2  
  .negative regulation of peroxidase activity
.regulation of synaptic vesicle exocytosis
.regulation of branching morphogenesis of a nerve
  + 64 more...
.protein kinase A binding
.ion channel binding
.protein homodimerization activity
  + 18 more...
.extracellular exosome
.membrane raft
.perikaryon
  + 25 more...
9 EBI-528269,EBI-2269715 TNRC6A  
  .phosphatidylinositol-mediated signaling
.neurotrophin TRK receptor signaling pathway
.innate immune response
  + 9 more...
.poly(A) RNA binding
.nucleotide binding
.micro-ribonucleoprotein complex
.cytosol
.nucleoplasm
.cytoplasmic mRNA processing body
10 EBI-528269,EBI-744193 DHX58  
  .positive regulation of RIG-I signaling pathway
.positive regulation of MDA-5 signaling pathway
.defense response to virus
  + 9 more...
.zinc ion binding
.ATP binding
.helicase activity
  + 3 more...
.cytoplasm
11 EBI-528269,EBI-2548480 ZMAT3  
  .positive regulation of apoptotic process
.regulation of growth
.protein transport
  + 2 more...
.poly(A) RNA binding
.zinc ion binding
.nucleolus
12 EBI-528269,EBI-6507625 TNRC6C  
  .positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.regulation of gene silencing by miRNA
.positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
  + 13 more...
.RNA binding
.nucleotide binding
.cytosol
13 EBI-528269,EBI-356402 TBK1  
  .defense response to virus
.defense response to Gram-positive bacterium
.positive regulation of transcription from RNA polymerase II promoter
  + 20 more...
.phosphoprotein binding
.ATP binding
.protein serine/threonine kinase activity
  + 2 more...
.endosome membrane
.cytosol
.cytoplasm
14 EBI-528269,EBI-2105113 CNOT7  
  .positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.RNA phosphodiester bond hydrolysis, exonucleolytic
.positive regulation of mRNA catabolic process
  + 17 more...
.metal ion binding
.signal transducer activity
.poly(A)-specific ribonuclease activity
  + 4 more...
.CCR4-NOT complex
.membrane
.cytosol
  + 2 more...
15 EBI-528269,EBI-947158 TNRC6B  
  .positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
.phosphatidylinositol-mediated signaling
  + 10 more...
.poly(A) RNA binding
.nucleotide binding
.cytosol
.cytoplasmic mRNA processing body
16 EBI-528269,EBI-395506 DICER1  
  .positive regulation of miRNA metabolic process
.RNA phosphodiester bond hydrolysis, endonucleolytic
.hair follicle cell proliferation
  + 47 more...
.pre-miRNA binding
.metal ion binding
.miRNA binding
  + 6 more...
.RISC-loading complex
.micro-ribonucleoprotein complex
.ARC complex
  + 8 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
ascites50
bladder100
blood65
bone27
bone marrow20
brain21
cervix61
connective tissue20
embryonic tissue37
eye76
heart44
intestine43
kidney23
larynx85
liver29
lung23
lymph22
lymph node167
mammary gland46
mouth15
muscle37
nerve128
ovary19
pancreas9
pharynx24
placenta67
prostate21
skin37
stomach10
testis27
thymus37
thyroid21
uterus21
vascular19
Health State
TissuesTPM*
normal38
bladder carcinoma56
breast (mammary gland) tumor53
cervical tumor86
chondrosarcoma12
colorectal tumor62
gastrointestinal tumor25
germ cell tumor79
glioma37
head and neck tumor29
kidney tumor43
leukemia42
liver tumor20
lung tumor38
lymphoma13
non-neoplasia31
ovarian tumor26
pancreatic tumor19
primitive neuroectodermal tumor of the CNS55
prostate cancer28
retinoblastoma172
skin tumor23
soft tissue/muscle tissue tumor31
uterine tumor22
Developmental Stage
TissuesTPM*
adult34
embryoid body28
blastocyst32
fetus75
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue6.9
adrenal gland4.4
appendix7
bone marrow15.3
cerebral cortex3.6
colon6.1
duodenum2.8
esophagus6.7
gallbladder5.2
heart muscle5.3
kidney3.5
liver2.9
lung3.5
lymph node5.3
ovary6.1
pancreas3.7
placenta7
prostate3.6
salivary gland2.4
skin4.3
small intestine4.2
spleen5.2
stomach6.3
testis6
thyroid gland4.7
urinary bladder5.3
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowMedium
breastHigh
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineMedium
colonHigh
duodenumHigh
endometrium 1High
endometrium 2Medium
epididymisMedium
esophagusHigh
fallopian tubeLow
gallbladderHigh
heart muscleMedium
hippocampusHigh
kidneyHigh
lateral ventricleHigh
liverHigh
lungMedium
lymph nodeHigh
nasopharynxHigh
oral mucosaMedium
ovaryLow
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateHigh
rectumHigh
salivary glandMedium
seminal vesicleMedium
skeletal muscleHigh
skin 1Medium
skin 2High
small intestineHigh
soft tissue 2Low
spleenHigh
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*606229, gene) Eukaryotic translation initiation factor 2c, subunit 2; EIF2C2OMIM


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2014-2019 (C) Yonsei Proteome Research Center