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> Protein (NX_Q9UKW4)
Protein (NX_Q9UKW4)
Protein
Gene SymbolVAV3 to neXtProt (NX_Q9UKW4)
DescriptionGuanine nucleotide exchange factor VAV3
Chromosome1
Location1p13.3 (108113782 ~ 108507766) to Ensembl
Sequene Features : Isoforms 4, Variants 151, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.apoptotic signaling pathway
.regulation of small GTPase mediated signal transduction
.B cell receptor signaling pathway
  + 22 more...
.metal ion binding
.Rac guanyl-nucleotide exchange factor activity
.GTPase activator activity
  + 2 more...
.extracellular exosome
.plasma membrane
.cytosol
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 151 1
2014-09-19protein level
4 127 1
2014-05-27protein level
4 127 1
2014-02-25protein level
4 124 1
2013-12-09protein level
4 113 1
2013-11-01protein level
4 109 1
2013-09-12protein level
4 109 1
2013-08-17protein level
4 109 1
2013-07-15protein level
4 63 1
2013-06-11protein level
4 63 1
2013-02-12protein level
4 30 7
2012-12-20protein level
4 28 7
2012-10-30protein level
4 35 7
2012-10-07protein level
4 35 2
2012-08-24protein level
4 24 2
2012-07-28protein level
4 24 2
2012-06-08protein level
4 27 2
2012-05-07protein level
4 27 2
2012-04-10protein level
4 27 2
2012-01-13protein level
3 15 2
2011-12-20protein level
3 15 2
2011-11-11protein level
3 15 2
2011-08-23protein level
3 15 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9UKW4-1
0 41 1 97713.2045
NX_Q9UKW4-2
2 35 1 86640.5627
NX_Q9UKW4-3
1 15 0 32583.5294
NX_Q9UKW4-4
1 40 1 100763.5806
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-297568,EBI-1039152 MET  
  .positive regulation of endothelial cell chemotaxis
.negative regulation of hydrogen peroxide-mediated programmed cell death
.semaphorin-plexin signaling pathway
  + 22 more...
.protein phosphatase binding
.ATP binding
.hepatocyte growth factor-activated receptor activity
.protein tyrosine kinase activity
.integral component of membrane
.cell surface
.basal plasma membrane
  + 3 more...
2 EBI-297568,EBI-79464 PIK3R1  
  .positive regulation of endoplasmic reticulum unfolded protein response
.positive regulation of establishment of protein localization to plasma membrane
.growth hormone receptor signaling pathway
  + 41 more...
.1-phosphatidylinositol-3-kinase regulator activity
.insulin receptor substrate binding
.insulin binding
  + 9 more...
.membrane
.phosphatidylinositol 3-kinase complex, class IA
.phosphatidylinositol 3-kinase complex
  + 5 more...
3 EBI-297568,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
4 EBI-297568,EBI-517684 GAB1  
  .interleukin-6-mediated signaling pathway
.labyrinthine layer development
.phosphatidylinositol-mediated signaling
  + 13 more...
.SH3/SH2 adaptor activity
.signal transducer activity
.cytosol
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites25
bladder66
brain13
connective tissue13
embryonic tissue9
esophagus49
eye28
heart22
intestine34
kidney56
liver24
lung2
lymph node33
mammary gland39
mouth151
muscle28
ovary19
pancreas4
placenta81
prostate5
skin18
testis16
thymus25
trachea154
uterus43
Health State
TissuesTPM*
normal25
bladder carcinoma113
breast (mammary gland) tumor53
esophageal tumor57
gastrointestinal tumor8
germ cell tumor26
head and neck tumor74
kidney tumor14
leukemia10
liver tumor20
non-neoplasia72
ovarian tumor26
pancreatic tumor9
soft tissue/muscle tissue tumor15
uterine tumor99
Developmental Stage
TissuesTPM*
adult26
blastocyst32
fetus25
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue3.3
adrenal gland3
appendix11.8
bone marrow12
cerebral cortex1.6
colon48.1
duodenum10.1
esophagus57
gallbladder4.1
heart muscle1.5
kidney85.6
liver1.8
lung4.9
lymph node12.8
pancreas11.2
placenta55.9
prostate3.1
salivary gland1.2
skin58.8
small intestine16.4
spleen10.9
stomach4.8
testis6.8
thyroid gland15.8
urinary bladder28.6
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*605541, gene) Vav3 oncogene; VAV3OMIM


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