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> Protein (NX_Q9UL45)
Protein (NX_Q9UL45)
Protein
Gene SymbolBLOC1S6 to neXtProt (NX_Q9UL45)
DescriptionBiogenesis of lysosome-related organelles complex 1 subunit 6
Chromosome15
Location15q21.1 (45879321 ~ 45908197) to Ensembl
Sequene Features : Isoforms 2, Variants 3, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.membrane fusion
.membrane organization
.positive regulation of pigment cell differentiation
  + 12 more...
.actin filament binding
.protein homodimerization activity
.identical protein binding
.syntaxin binding
.BLOC-1 complex
.transport vesicle
.extrinsic component of membrane
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 3 0
2014-09-19protein level
2 12 0
2014-05-27protein level
2 10 0
2014-02-25protein level
2 10 0
2013-12-09protein level
2 8 0
2013-11-01protein level
2 8 0
2013-09-12protein level
2 8 0
2013-08-17protein level
2 8 0
2013-07-15protein level
2 5 0
2013-06-11protein level
2 5 0
2013-02-12protein level
2 2 0
2012-12-20protein level
2 2 0
2012-10-30protein level
2 2 0
2012-10-07protein level
2 2 0
2012-08-24protein level
2 2 0
2012-07-28protein level
2 2 0
2012-06-08protein level
2 2 0
2012-05-07protein level
2 1 0
2012-04-10protein level
2 1 0
2012-01-13protein level
2 0 0
2011-12-20protein level
2 0 0
2011-11-11protein level
2 0 0
2011-08-23protein level
2 0 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9UL45-1
4 2 0 19731.1997
NX_Q9UL45-2
1 2 0 8593.2156
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-465781,EBI-10283466 SYCE3  
  .cell division
.positive regulation of apoptotic process
.spermatogenesis
  + 2 more...
.N/A .chromosome
.nucleus
.central element
2 EBI-465781,EBI-714135 STX11  
  .membrane fusion
.vesicle docking
.natural killer cell degranulation
  + 4 more...
.SNAP receptor activity
.SNARE binding
.SNARE complex
.integral component of membrane
.endomembrane system
  + 3 more...
3 EBI-465781,EBI-296723 SNAPIN  
  .positive regulation of late endosome to lysosome transport
.autophagic vacuole maturation
.terminal button organization
  + 14 more...
.SNARE binding .perinuclear region of cytoplasm
.synapse
.BLOC-1 complex
  + 9 more...
4 EBI-465781,EBI-347978 NUP62  
  .regulation of cellular response to heat
.transmembrane transport
.mRNA transport
  + 34 more...
.thyroid hormone receptor binding
.ubiquitin binding
.SH2 domain binding
  + 3 more...
.Flemming body
.pore complex
.intracellular membrane-bounded organelle
  + 7 more...
5 EBI-465781,EBI-348630 BLOC1S1  
  .activation of mitophagy in response to mitochondrial depolarization
.membrane organization
.platelet dense granule organization
  + 7 more...
.N/A .extracellular exosome
.BLOC-1 complex
.cytosol
  + 4 more...
6 EBI-465781,EBI-394678 MED21  
  .positive regulation of transcription from RNA polymerase II promoter
.stem cell maintenance
.regulation of transcription from RNA polymerase II promoter
  + 2 more...
.DNA-directed RNA polymerase activity
.transcription coactivator activity
.mediator complex
7 EBI-465781,EBI-715074 DCTN2  
  .melanosome transport
.antigen processing and presentation of exogenous peptide antigen via MHC class II
.cell proliferation
  + 5 more...
.spectrin binding
.motor activity
.extracellular exosome
.vesicle
.growth cone
  + 8 more...
8 EBI-465781,EBI-395421 SMN2  
  .ncRNA metabolic process
.gene expression
.nervous system development
  + 2 more...
.identical protein binding
.RNA binding
.Gemini of coiled bodies
.SMN-Sm protein complex
.SMN complex
  + 7 more...
9 EBI-465781,EBI-10254194 CORO6  
  .actin cytoskeleton organization .actin filament binding .actin cytoskeleton
10 EBI-465781,EBI-465930 BLOC1S3  
  .membrane organization
.platelet dense granule organization
.anterograde synaptic vesicle transport
  + 12 more...
.N/A .BLOC-1 complex
.transport vesicle
.cytosol
11 EBI-465781,EBI-465872 BLOC1S2  
  .mitochondrial outer membrane permeabilization
.platelet dense granule organization
.anterograde synaptic vesicle transport
  + 8 more...
.gamma-tubulin binding
.protein C-terminus binding
.recycling endosome
.BLOC-1 complex
.centrosome
  + 3 more...
12 EBI-465781,EBI-10175300 CCHCR1  
  .cell differentiation
.multicellular organismal development
.protein export from nucleus
.N/A .centriole
.cytoplasm
.nucleus
13 EBI-465781,EBI-465861 BLOC1S5  
  .positive regulation of pigment cell differentiation
.anterograde synaptic vesicle transport
.endosome to melanosome transport
  + 5 more...
.N/A .BLOC-1 complex
.transport vesicle
14 EBI-465781,EBI-741854 SKA1  
  .cell division
.regulation of microtubule polymerization or depolymerization
.small GTPase mediated signal transduction
  + 3 more...
.microtubule binding .microtubule cytoskeleton
.spindle microtubule
.cytosol
.condensed chromosome outer kinetochore
15 EBI-465781,EBI-2514791 HAUS1  
  .cell division
.centrosome organization
.spindle assembly
.mitotic nuclear division
.N/A .HAUS complex
.microtubule
.centrosome
  + 2 more...
16 EBI-465781,EBI-465804 DTNBP1  
  .membrane organization
.regulation of dopamine receptor signaling pathway
.platelet dense granule organization
  + 11 more...
.N/A .postsynaptic membrane
.dendritic spine
.neuron projection
  + 14 more...
17 EBI-465781,EBI-10171416 CCDC136  
  .N/A .N/A .integral component of membrane
.mitochondrion
18 EBI-465781,EBI-465852 BLOC1S4  
  .platelet aggregation
.membrane organization
.neuromuscular process controlling balance
  + 5 more...
.N/A .BLOC-1 complex
.cytosol
.cytoplasm
19 EBI-465781,EBI-743598 ABI2  
  .positive regulation of Arp2/3 complex-mediated actin nucleation
.peptidyl-tyrosine phosphorylation
.Rac protein signal transduction
  + 5 more...
.proline-rich region binding
.protein complex binding
.ubiquitin protein ligase binding
  + 4 more...
.SCAR complex
.filopodium
.lamellipodium
  + 3 more...
20 EBI-465781,EBI-913954 RABGEF1  
  .negative regulation of Kit signaling pathway
.negative regulation of interleukin-6 secretion
.regulation of Fc receptor mediated stimulatory signaling pathway
  + 9 more...
.Rab GTPase binding
.Rab guanyl-nucleotide exchange factor activity
.zinc ion binding
  + 2 more...
.recycling endosome
.vesicle
.early endosome
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland151
bladder100
blood89
bone13
bone marrow20
brain105
cervix41
connective tissue46
embryonic tissue89
esophagus248
eye67
heart44
intestine34
kidney66
liver58
lung47
lymph45
lymph node256
mammary gland13
mouth45
muscle65
ovary39
pancreas70
parathyroid48
pharynx24
placenta70
prostate158
salivary gland148
skin142
spleen37
testis96
thymus163
thyroid42
tonsil176
trachea251
uterus120
vascular96
Health State
TissuesTPM*
normal88
adrenal tumor316
bladder carcinoma113
breast (mammary gland) tumor21
cervical tumor28
chondrosarcoma36
colorectal tumor26
esophageal tumor231
germ cell tumor91
glioma18
head and neck tumor44
kidney tumor87
leukemia10
liver tumor93
lung tumor48
lymphoma55
non-neoplasia62
ovarian tumor39
pancreatic tumor19
primitive neuroectodermal tumor of the CNS55
prostate cancer279
retinoblastoma129
skin tumor79
soft tissue/muscle tissue tumor31
uterine tumor44
Developmental Stage
TissuesTPM*
adult64
embryoid body157
blastocyst48
neonate225
fetus78
infant170
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue26.5
adrenal gland34.5
appendix35.7
bone marrow30.5
cerebral cortex38.5
colon22.4
duodenum22
esophagus22.3
gallbladder31
heart muscle24.9
kidney23.3
liver15.5
lung19.7
lymph node43.1
ovary40.7
pancreas9.9
placenta22.9
prostate37.2
salivary gland16.4
skin13.4
small intestine20.9
spleen24.2
stomach20.9
testis21.4
thyroid gland46.6
urinary bladder35.9
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604310, gene) Pallidin; PLDNOMIM
2(#614171, phenotype) Hermansky-pudlak syndrome 9; HPS9OMIM


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