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> Protein (NX_Q9ULH1)
Protein (NX_Q9ULH1)
Protein
Gene SymbolASAP1 to neXtProt (NX_Q9ULH1)
DescriptionArf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1
Chromosome8
Location8q24.21 (131064353 ~ 131455906) to Ensembl
Sequene Features : Isoforms 2, Variants 136, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cilium morphogenesis
.organelle organization
.zinc ion binding
.phosphatidylinositol-3,4,5-trisphosphate binding
.phosphatidylinositol-4,5-bisphosphate binding
.GTPase activator activity
.membrane
.cytosol
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 136 9
2014-09-19protein level
2 93 9
2014-05-27protein level
2 93 9
2014-02-25protein level
2 92 9
2013-12-09protein level
2 76 9
2013-11-01protein level
2 74 9
2013-09-12protein level
2 74 9
2013-08-17protein level
2 74 9
2013-07-15protein level
2 52 9
2013-06-11protein level
2 52 9
2013-02-12protein level
2 18 10
2012-12-20protein level
2 19 10
2012-10-30protein level
2 23 10
2012-10-07protein level
2 23 5
2012-08-24protein level
2 14 5
2012-07-28protein level
2 14 5
2012-06-08protein level
2 1 5
2012-05-07protein level
2 1 5
2012-04-10protein level
2 1 5
2012-01-13protein level
2 1 5
2011-12-20protein level
2 1 5
2011-11-11protein level
2 1 5
2011-08-23protein level
2 1 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9ULH1-1
0 51 1 125419.9687
NX_Q9ULH1-2
0 51 1 125819.2015
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-346622,EBI-515315 FYN  
  .negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.positive regulation of protein localization to nucleus
.cellular response to peptide hormone stimulus
  + 47 more...
.growth factor receptor binding
.ephrin receptor binding
.metal ion binding
  + 4 more...
.extrinsic component of cytoplasmic side of plasma membrane
.postsynaptic density
.plasma membrane
  + 5 more...
2 EBI-346622,EBI-346340 HCK  
  .positive regulation of actin cytoskeleton reorganization
.regulation of podosome assembly
.cellular response to peptide hormone stimulus
  + 28 more...
.ATP binding
.receptor binding
.non-membrane spanning protein tyrosine kinase activity
.protein tyrosine kinase activity
.cell projection
.extrinsic component of cytoplasmic side of plasma membrane
.transport vesicle
  + 7 more...
3 EBI-346622,EBI-3390054 UBC  
  .programmed necrotic cell death
.apoptotic signaling pathway
.energy homeostasis
  + 90 more...
.poly(A) RNA binding
.protease binding
.extracellular exosome
.endocytic vesicle membrane
.endosome membrane
  + 3 more...
4 EBI-346622,EBI-621482 SRC  
  .regulation of caveolin-mediated endocytosis
.negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway
  + 100 more...
.scaffold protein binding
.growth factor receptor binding
.hormone receptor binding
  + 14 more...
.extracellular exosome
.perinuclear region of cytoplasm
.neuron projection
  + 13 more...
5 EBI-346622,EBI-389883 NCK1  
  .negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.negative regulation of PERK-mediated unfolded protein response
  + 23 more...
.eukaryotic initiation factor eIF2 binding
.receptor tyrosine kinase binding
.protein binding, bridging
  + 5 more...
.vesicle membrane
.cell-cell junction
.plasma membrane
  + 6 more...
6 EBI-346622,EBI-79387 PLCG1  
  .cellular response to epidermal growth factor stimulus
.positive regulation of release of sequestered calcium ion into cytosol
.leukocyte migration
  + 24 more...
.protein kinase binding
.calcium ion binding
.neurotrophin TRKA receptor binding
  + 3 more...
.cell projection
.lamellipodium
.COP9 signalosome
  + 5 more...
7 EBI-346622,EBI-886 CRK  
  .ephrin receptor signaling pathway
.neurotrophin TRK receptor signaling pathway
.vascular endothelial growth factor receptor signaling pathway
  + 9 more...
.ephrin receptor binding
.SH2 domain binding
.extracellular exosome
.actin cytoskeleton
.plasma membrane
  + 3 more...
8 EBI-346622,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
9 EBI-346622,EBI-744027 CBLB  
  .negative regulation of T cell receptor signaling pathway
.negative regulation of alpha-beta T cell proliferation
.positive regulation of protein catabolic process
  + 7 more...
.ligase activity
.zinc ion binding
.calcium ion binding
  + 2 more...
.plasma membrane
.cytosol
.cytoplasm
.nucleoplasm
10 EBI-346622,EBI-351886 CTTN  
  .negative regulation of extrinsic apoptotic signaling pathway
.lamellipodium organization
.dendritic spine maintenance
  + 12 more...
.profilin binding .mitotic spindle midzone
.extracellular exosome
.dendritic spine
  + 10 more...
11 EBI-346622,EBI-346595 SH3KBP1  
  .negative regulation of epidermal growth factor receptor signaling pathway
.cell migration
.regulation of cell shape
  + 5 more...
.N/A .synapse
.neuron projection
.cytoplasmic vesicle membrane
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
blood65
bone41
bone marrow20
brain41
cervix41
connective tissue46
ear248
embryonic tissue75
esophagus49
eye52
heart22
intestine12
kidney66
larynx85
liver58
lung44
lymph22
lymph node89
mammary gland92
mouth15
muscle65
nerve64
ovary49
pancreas65
pharynx24
placenta84
prostate26
skin94
spleen18
stomach52
testis48
thymus12
thyroid21
trachea19
uterus56
Health State
TissuesTPM*
normal66
breast (mammary gland) tumor107
cervical tumor57
chondrosarcoma72
colorectal tumor8
esophageal tumor57
gastrointestinal tumor42
germ cell tumor68
glioma37
head and neck tumor29
kidney tumor43
leukemia42
liver tumor83
lung tumor48
lymphoma13
non-neoplasia31
ovarian tumor26
pancreatic tumor57
primitive neuroectodermal tumor of the CNS31
prostate cancer19
skin tumor47
soft tissue/muscle tissue tumor39
uterine tumor77
Developmental Stage
TissuesTPM*
adult58
embryoid body85
blastocyst65
fetus116
infant42
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue20.4
adrenal gland24.4
appendix18.4
bone marrow41.4
cerebral cortex21.3
colon8.7
duodenum6.5
esophagus13.6
gallbladder27.7
heart muscle17.8
kidney8.1
liver7.1
lung21.2
lymph node25
ovary18.3
pancreas4.2
placenta33.6
prostate12.3
salivary gland4.2
skin14.3
small intestine7.7
spleen36.5
stomach7.3
testis43.3
thyroid gland20.6
urinary bladder22.2
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowMedium
breastHigh
bronchusHigh
cerebellumMedium
cerebral cortexMedium
cervix, uterineMedium
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2Medium
epididymisHigh
esophagusMedium
fallopian tubeMedium
gallbladderHigh
heart muscleHigh
hippocampusLow
kidneyHigh
lateral ventricleLow
liverHigh
lungMedium
lymph nodeMedium
nasopharynxHigh
oral mucosaMedium
ovaryLow
pancreasHigh
parathyroid glandMedium
placentaHigh
prostateHigh
rectumHigh
salivary glandHigh
seminal vesicleMedium
skin 1High
skin 2Medium
small intestineHigh
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Medium
spleenMedium
stomach 1High
stomach 2High
testisMedium
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*605953, gene) Development- and differentiation-enhancing factor 1; DDEF1OMIM


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