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> Protein (NX_Q9ULM6)
Protein (NX_Q9ULM6)
Protein
Gene SymbolCNOT6 to neXtProt (NX_Q9ULM6)
DescriptionCCR4-NOT transcription complex subunit 6
Chromosome5
Location5q35.3 (179921412 ~ 180005405) to Ensembl
Sequene Features : Isoforms 1, Variants 59, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of ligand-dependent nuclear receptor transcription coactivator activity
.RNA phosphodiester bond hydrolysis, exonucleolytic
.nuclear-transcribed mRNA catabolic process, no-go decay
  + 10 more...
.metal ion binding
.poly(A)-specific ribonuclease activity
.exoribonuclease activity
.RNA binding
.CCR4-NOT complex
.membrane
.cytosol
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 59 1
2014-09-19protein level
1 44 1
2014-05-27protein level
1 44 1
2014-02-25protein level
1 44 1
2013-12-09protein level
1 37 1
2013-11-01protein level
1 37 1
2013-09-12protein level
1 37 2
2013-08-17protein level
1 37 2
2013-07-15protein level
1 23 1
2013-06-11protein level
1 23 1
2013-02-12protein level
1 8 1
2012-12-20protein level
1 7 1
2012-10-30protein level
1 9 1
2012-10-07protein level
1 9 1
2012-08-24protein level
1 9 1
2012-07-28protein level
1 9 1
2012-06-08protein level
1 9 1
2012-05-07protein level
1 8 1
2012-04-10protein level
1 8 1
2012-01-13protein level
1 3 1
2011-12-20protein level
1 3 1
2011-11-11protein level
1 3 1
2011-08-23protein level
1 3 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9ULM6-1
22 0 4 63266.1585
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2104530,EBI-1222758 CNOT1  
  .regulation of stem cell maintenance
.positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.RNA phosphodiester bond hydrolysis, exonucleolytic
  + 13 more...
.armadillo repeat domain binding
.poly(A) RNA binding
.retinoic acid receptor binding
  + 3 more...
.CCR4-NOT complex
.membrane
.cytosol
  + 4 more...
2 EBI-2104530,EBI-6507625 TNRC6C  
  .positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.regulation of gene silencing by miRNA
.positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
  + 13 more...
.RNA binding
.nucleotide binding
.cytosol
3 EBI-2104530,EBI-742299 CNOT8  
  .RNA phosphodiester bond hydrolysis, exonucleolytic
.positive regulation of mRNA catabolic process
.exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
  + 9 more...
.metal ion binding
.poly(A)-specific ribonuclease activity
.RNA binding
  + 2 more...
.CCR4-NOT complex
.cytosol
.nucleus
.intracellular
4 EBI-2104530,EBI-2105113 CNOT7  
  .positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.RNA phosphodiester bond hydrolysis, exonucleolytic
.positive regulation of mRNA catabolic process
  + 17 more...
.metal ion binding
.signal transducer activity
.poly(A)-specific ribonuclease activity
  + 4 more...
.CCR4-NOT complex
.membrane
.cytosol
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
ascites25
bladder33
blood32
bone41
bone marrow61
brain31
cervix82
connective tissue33
ear310
embryonic tissue103
eye52
heart22
intestine38
kidney9
liver48
lung53
lymph node100
mammary gland46
mouth15
muscle18
ovary49
pancreas37
parathyroid97
pharynx24
placenta28
prostate52
skin66
stomach20
testis27
thymus37
thyroid21
trachea38
uterus94
Health State
TissuesTPM*
normal48
adrenal tumor158
breast (mammary gland) tumor32
cervical tumor115
chondrosarcoma72
colorectal tumor17
gastrointestinal tumor8
germ cell tumor45
glioma18
head and neck tumor14
kidney tumor14
leukemia42
liver tumor104
lung tumor19
lymphoma13
non-neoplasia41
ovarian tumor78
pancreatic tumor19
primitive neuroectodermal tumor of the CNS39
prostate cancer19
retinoblastoma86
skin tumor55
soft tissue/muscle tissue tumor71
uterine tumor77
Developmental Stage
TissuesTPM*
adult37
embryoid body128
blastocyst97
fetus91
infant42
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue5.8
adrenal gland7.3
appendix12.2
bone marrow5.7
cerebral cortex7.7
colon10.8
duodenum10.7
esophagus11.1
gallbladder8.4
heart muscle4.8
kidney9.2
liver2.9
lung9.9
lymph node11.4
ovary9.8
pancreas2.8
placenta12
prostate10.6
salivary gland4.9
skin8.2
small intestine11.9
spleen10
stomach10.6
testis14.3
thyroid gland9.9
urinary bladder15.1
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*608951, gene) Ccr4-not transcription complex, subunit 6; CNOT6OMIM


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