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> Protein (NX_Q9ULP0)
Protein (NX_Q9ULP0)
Protein
Gene SymbolNDRG4 to neXtProt (NX_Q9ULP0)
DescriptionProtein NDRG4
Chromosome16
Location16q21 (58496750 ~ 58547532) to Ensembl
Sequene Features : Isoforms 8, Variants 45, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of ERK1 and ERK2 cascade
.cardiac muscle cell proliferation
.negative regulation of smooth muscle cell proliferation
  + 9 more...
.N/A .basolateral plasma membrane
.cytosol
.endoplasmic reticulum membrane
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
8 45 1
2014-09-19protein level
8 40 1
2014-05-27protein level
8 40 1
2014-02-25protein level
8 40 1
2013-12-09protein level
8 29 1
2013-11-01protein level
8 27 1
2013-09-12protein level
8 27 1
2013-08-17protein level
8 27 1
2013-07-15protein level
8 20 1
2013-06-11protein level
8 20 1
2013-02-12protein level
6 9 1
2012-12-20protein level
6 9 1
2012-10-30protein level
6 9 1
2012-10-07protein level
6 9 1
2012-08-24protein level
6 9 1
2012-07-28protein level
6 9 1
2012-06-08protein level
6 9 1
2012-05-07protein level
6 7 1
2012-04-10protein level
6 7 1
2012-01-13protein level
6 0 1
2011-12-20protein level
6 3 1
2011-11-11transcript level
6 3 1
2011-08-23transcript level
6 3 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9ULP0-1
2 14 0 38434.029
NX_Q9ULP0-2
0 15 0 37065.2166
NX_Q9ULP0-3
1 17 0 40619.1021
NX_Q9ULP0-4
1 14 0 37021.2445
NX_Q9ULP0-5
2 14 0 38875.1409
NX_Q9ULP0-6
1 17 0 42858.3828
NX_Q9ULP0-7
3 14 0 40023.7292
NX_Q9ULP0-8
2 14 0 39142.3605
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-10323810,EBI-714543 ARL6IP1  
  .cotranslational protein targeting to membrane .N/A .integral component of membrane
.membrane
.cytosol
.Sec61 translocon complex
2 EBI-10323810,EBI-741181 AGTRAP  
  .regulation of blood pressure
.response to hypoxia
.angiotensin type II receptor activity .intracellular membrane-bounded organelle
.cytoplasmic vesicle membrane
.integral component of membrane
  + 6 more...
3 EBI-10323810,EBI-2548702 CMTM5  
  .negative regulation of myoblast differentiation
.chemotaxis
.N/A .integral component of membrane
.extracellular space
4 EBI-10323810,EBI-712367 RABAC1  
  .N/A .identical protein binding .cell junction
.integral component of membrane
.membrane
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland121
brain1249
connective tissue13
embryonic tissue46
esophagus49
eye138
heart122
intestine12
kidney256
larynx383
lung32
lymph node11
mammary gland6
mouth105
muscle65
nerve708
pancreas46
pituitary gland60
placenta3
prostate21
spleen149
stomach20
testis188
thymus87
umbilical cord145
uterus30
vascular38
Health State
TissuesTPM*
normal434
breast (mammary gland) tumor10
chondrosarcoma24
colorectal tumor26
esophageal tumor57
gastrointestinal tumor16
germ cell tumor94
glioma93
head and neck tumor119
kidney tumor769
lung tumor9
lymphoma13
non-neoplasia103
pancreatic tumor76
primitive neuroectodermal tumor of the CNS94
soft tissue/muscle tissue tumor39
Developmental Stage
TissuesTPM*
adult69
embryoid body14
blastocyst65
neonate64
fetus337
infant212
juvenile233
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue7.6
adrenal gland150.3
appendix4.4
cerebral cortex282.4
colon4.7
duodenum4.7
esophagus16.8
gallbladder4.8
heart muscle220.8
kidney3.1
lung19.3
lymph node6
ovary1.6
pancreas3.2
placenta2.8
prostate2.8
salivary gland4
skin8.3
small intestine5.6
spleen36.6
stomach3.8
testis67.5
thyroid gland3.3
urinary bladder3.5
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowLow
breastMedium
bronchusHigh
cerebellumHigh
cerebral cortexMedium
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Low
endometrium 2Low
epididymisMedium
esophagusLow
fallopian tubeLow
gallbladderMedium
heart muscleMedium
hippocampusHigh
kidneyHigh
lateral ventricleHigh
liverLow
lungMedium
lymph nodeHigh
nasopharynxHigh
ovaryMedium
pancreasMedium
parathyroid glandMedium
placentaLow
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleMedium
skeletal muscleLow
skin 2Low
small intestineMedium
soft tissue 1Medium
soft tissue 2Low
spleenHigh
stomach 1High
stomach 2High
testisMedium
thyroid glandMedium
tonsilHigh
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*614463, gene) Nmyc downstream-regulated gene 4; NDRG4OMIM


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