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> Protein (NX_Q9ULV0)
Protein (NX_Q9ULV0)
Protein
Gene SymbolMYO5B to neXtProt (NX_Q9ULV0)
DescriptionUnconventional myosin-Vb
Chromosome18
Location18q21.1 (47349183 ~ 47721463) to Ensembl
Sequene Features : Isoforms 3, Variants 300, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.transmembrane transport
.endosome localization
.vesicle-mediated transport
  + 4 more...
.Rab GTPase binding
.ATP binding
.microfilament motor activity
.extracellular exosome
.apical cortex
.protein complex
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 300 2
2014-09-19protein level
1 210 2
2014-05-27protein level
1 210 2
2014-02-25protein level
1 209 2
2013-12-09protein level
1 134 2
2013-11-01protein level
1 131 2
2013-09-12protein level
1 131 2
2013-08-17protein level
1 131 2
2013-07-15protein level
1 93 2
2013-06-11protein level
1 93 2
2013-02-12protein level
1 49 2
2012-12-20protein level
1 43 2
2012-10-30protein level
1 66 2
2012-10-07protein level
1 66 2
2012-08-24protein level
1 49 2
2012-07-28protein level
1 48 2
2012-06-08protein level
1 52 2
2012-05-07protein level
1 52 2
2012-04-10protein level
1 52 2
2012-01-13protein level
1 41 2
2011-12-20protein level
1 41 2
2011-11-11protein level
1 41 2
2011-08-23protein level
1 41 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9ULV0-1
40 43 7 213537.6783
NX_Q9ULV0-2
1 43 1 111688.8599
NX_Q9ULV0-3
0 22 0 47952.2421
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-311356,EBI-533224 TCF4  
  .protein-DNA complex assembly
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 3 more...
.E-box binding
.protein heterodimerization activity
.bHLH transcription factor binding
  + 9 more...
.transcription factor complex
.nucleus
2 EBI-311356,EBI-752094 BNIP2  
  .positive regulation of muscle cell differentiation
.positive regulation of GTPase activity
.negative regulation of apoptotic process
  + 2 more...
.identical protein binding
.calcium ion binding
.GTPase activator activity
.perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.cytosol
  + 2 more...
3 EBI-311356,EBI-2130429 TRIM54  
  .cell differentiation
.multicellular organismal development
.signal transduction
  + 2 more...
.zinc ion binding
.signal transducer activity
.Z disc
.microtubule associated complex
.microtubule
4 EBI-311356,EBI-10187270 AMOTL2  
  .hippo signaling
.Wnt signaling pathway
.N/A .recycling endosome
.cytoplasmic vesicle
.apical plasma membrane
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
ascites150
bladder33
brain8
cervix103
connective tissue33
embryonic tissue28
eye52
heart11
intestine68
kidney28
liver19
lung26
lymph node11
mammary gland132
muscle9
ovary39
pancreas23
parathyroid48
pharynx24
placenta31
prostate26
stomach31
testis34
thyroid107
trachea38
uterus25
Health State
TissuesTPM*
normal27
bladder carcinoma56
breast (mammary gland) tumor75
cervical tumor28
chondrosarcoma24
colorectal tumor97
gastrointestinal tumor67
germ cell tumor7
head and neck tumor29
kidney tumor14
liver tumor20
lung tumor48
non-neoplasia20
ovarian tumor52
prostate cancer19
retinoblastoma43
soft tissue/muscle tissue tumor23
uterine tumor66
Developmental Stage
TissuesTPM*
adult36
embryoid body42
fetus23
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adrenal gland1.8
appendix8
cerebral cortex1.2
colon41
duodenum48.6
esophagus22.5
gallbladder11.5
heart muscle1.3
kidney16.6
liver8.2
lung12.3
lymph node2.4
pancreas8
placenta6.2
prostate11.2
salivary gland15.4
skin14.7
small intestine49.9
spleen1.2
stomach31.2
testis13.2
thyroid gland28.4
urinary bladder9.2
Tissues
TissuesExpression level
adrenal glandLow
appendixHigh
breastHigh
bronchusHigh
cerebral cortexLow
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1High
endometrium 2High
epididymisHigh
esophagusMedium
fallopian tubeHigh
gallbladderHigh
heart muscleLow
hippocampusLow
kidneyHigh
lateral ventricleLow
liverMedium
lungMedium
nasopharynxHigh
oral mucosaMedium
ovaryHigh
pancreasHigh
parathyroid glandMedium
placentaHigh
prostateMedium
rectumHigh
salivary glandHigh
seminal vesicleHigh
skin 1Medium
skin 2High
small intestineHigh
smooth muscleMedium
stomach 1High
stomach 2High
testisLow
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#251850, phenotype) Diarrhea 2, with microvillus atrophy; DIAR2OMIM
2(*606540, gene) Myosin vb; MYO5BOMIM


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