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> Protein (NX_Q9ULW0)
Protein (NX_Q9ULW0)
Protein
Gene SymbolTPX2 to neXtProt (NX_Q9ULW0)
DescriptionTargeting protein for Xklp2
Chromosome20
Location20q11.21 (30327074 ~ 30389608) to Ensembl
Sequene Features : Isoforms 2, Variants 77, PTMs 23 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of mitotic spindle organization
.cell division
.activation of protein kinase activity
  + 3 more...
.protein kinase binding
.GTP binding
.ATP binding
.axon hillock
.microtubule cytoskeleton
.microtubule
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 77 23
2014-09-19protein level
1 59 23
2014-05-27protein level
1 59 23
2014-02-25protein level
1 59 21
2013-12-09protein level
1 46 21
2013-11-01protein level
1 45 15
2013-09-12protein level
1 45 15
2013-08-17protein level
1 45 15
2013-07-15protein level
1 32 15
2013-06-11protein level
1 32 15
2013-02-12protein level
1 14 34
2012-12-20protein level
1 14 34
2012-10-30protein level
1 17 34
2012-10-07protein level
1 17 34
2012-08-24protein level
1 17 34
2012-07-28protein level
1 17 34
2012-06-08protein level
1 21 34
2012-05-07protein level
1 14 34
2012-04-10protein level
1 14 34
2012-01-13protein level
1 8 34
2011-12-20protein level
1 8 34
2011-11-11protein level
1 8 33
2011-08-23protein level
1 8 33
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9ULW0-1
1 31 0 85599.7393
NX_Q9ULW0-2
3 31 0 89337.5363
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1037322,EBI-448680 AURKA  
  .neuron projection extension
.positive regulation of oocyte maturation
.negative regulation of spindle checkpoint
  + 21 more...
.histone serine kinase activity
.protein kinase binding
.ATP binding
  + 3 more...
.meiotic spindle
.mitotic spindle
.spindle midzone
  + 14 more...
2 EBI-1037322,EBI-389883 NCK1  
  .negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.negative regulation of PERK-mediated unfolded protein response
  + 23 more...
.eukaryotic initiation factor eIF2 binding
.receptor tyrosine kinase binding
.protein binding, bridging
  + 5 more...
.vesicle membrane
.cell-cell junction
.plasma membrane
  + 6 more...
3 EBI-1037322,EBI-79464 PIK3R1  
  .positive regulation of endoplasmic reticulum unfolded protein response
.positive regulation of establishment of protein localization to plasma membrane
.growth hormone receptor signaling pathway
  + 41 more...
.1-phosphatidylinositol-3-kinase regulator activity
.insulin receptor substrate binding
.insulin binding
  + 9 more...
.membrane
.phosphatidylinositol 3-kinase complex, class IA
.phosphatidylinositol 3-kinase complex
  + 5 more...
4 EBI-1037322,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
ascites552
bladder66
blood98
bone181
bone marrow61
brain43
cervix103
connective tissue87
ear186
embryonic tissue164
esophagus198
eye57
heart67
intestine219
kidney90
larynx42
liver228
lung77
lymph248
lymph node167
mammary gland112
mouth302
muscle56
nerve64
ovary197
pancreas107
pharynx49
placenta81
prostate89
salivary gland49
skin151
spleen93
stomach125
testis225
thymus426
thyroid42
tonsil293
trachea57
uterus103
vascular96
Health State
TissuesTPM*
normal65
adrenal tumor79
bladder carcinoma170
breast (mammary gland) tumor182
cervical tumor115
chondrosarcoma120
colorectal tumor337
esophageal tumor231
gastrointestinal tumor295
germ cell tumor227
glioma93
head and neck tumor171
kidney tumor101
leukemia127
liver tumor354
lung tumor165
lymphoma235
non-neoplasia10
ovarian tumor262
pancreatic tumor219
primitive neuroectodermal tumor of the CNS133
prostate cancer163
retinoblastoma150
skin tumor199
soft tissue/muscle tissue tumor223
uterine tumor55
Developmental Stage
TissuesTPM*
adult104
embryoid body200
blastocyst227
neonate225
fetus104
infant85
juvenile287
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue1.7
appendix13.3
bone marrow28.8
cerebral cortex1.7
colon11.2
duodenum8.1
esophagus7.8
gallbladder2
liver2.5
lung1.3
lymph node25.2
placenta8.6
skin8.2
small intestine8.7
spleen4
stomach6.5
testis28.7
urinary bladder5.4
Tissues
TissuesExpression level
adrenal glandHigh
appendixMedium
bone marrowHigh
breastMedium
bronchusMedium
cerebellumMedium
cerebral cortexMedium
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Low
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderLow
hippocampusMedium
kidneyLow
lateral ventricleMedium
liverLow
lungMedium
lymph nodeLow
nasopharynxMedium
oral mucosaMedium
pancreasMedium
parathyroid glandMedium
placentaMedium
rectumMedium
seminal vesicleLow
skeletal muscleLow
skin 1High
skin 2Medium
small intestineLow
smooth muscleLow
soft tissue 2Medium
stomach 1High
stomach 2High
testisHigh
thyroid glandMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*605917, gene) Chromosome 20 open reading frame 1; C20ORF1OMIM


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