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> Protein (NX_Q9ULZ2)
Protein (NX_Q9ULZ2)
Protein
Gene SymbolSTAP1 to neXtProt (NX_Q9ULZ2)
DescriptionSignal-transducing adaptor protein 1
Chromosome4
Location4q13.2 (68424446 ~ 68473055) to Ensembl
Sequene Features : Isoforms 1, Variants 51, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of actin cytoskeleton reorganization
.positive regulation of non-membrane spanning protein tyrosine kinase activity
.positive regulation of microglial cell activation
  + 10 more...
.protein kinase binding
.phospholipid binding
.SH3/SH2 adaptor activity
  + 2 more...
.protein complex
.mitochondrion
.cytoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 51 1
2014-09-19protein level
1 39 1
2014-05-27protein level
1 39 1
2014-02-25protein level
1 36 1
2013-12-09protein level
1 30 1
2013-11-01protein level
1 28 1
2013-09-12protein level
1 28 1
2013-08-17protein level
1 28 1
2013-07-15protein level
1 14 1
2013-06-11protein level
1 14 1
2013-02-12protein level
1 6 2
2012-12-20protein level
1 5 2
2012-10-30protein level
1 5 2
2012-10-07protein level
1 5 2
2012-08-24protein level
1 3 2
2012-07-28protein level
1 3 2
2012-06-08protein level
1 3 2
2012-05-07protein level
1 2 2
2012-04-10protein level
1 2 2
2012-01-13protein level
1 1 2
2011-12-20protein level
1 1 2
2011-11-11protein level
1 1 2
2011-08-23protein level
1 1 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9ULZ2-1
13 0 0 34269.6706
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-6083058,EBI-1039152 MET  
  .positive regulation of endothelial cell chemotaxis
.negative regulation of hydrogen peroxide-mediated programmed cell death
.semaphorin-plexin signaling pathway
  + 22 more...
.protein phosphatase binding
.ATP binding
.hepatocyte growth factor-activated receptor activity
.protein tyrosine kinase activity
.integral component of membrane
.cell surface
.basal plasma membrane
  + 3 more...
2 EBI-6083058,EBI-608057 AR  
  .negative regulation of extrinsic apoptotic signaling pathway
.regulation of establishment of protein localization to plasma membrane
.protein oligomerization
  + 21 more...
.ATPase binding
.protein dimerization activity
.transcription regulatory region DNA binding
  + 14 more...
.protein complex
.cytosol
.cytoplasm
  + 3 more...
3 EBI-6083058,EBI-1379503 KIT  
  .melanocyte adhesion
.melanocyte migration
.cellular response to thyroid hormone stimulus
  + 69 more...
.metal ion binding
.protein homodimerization activity
.cytokine binding
  + 5 more...
.mast cell granule
.integral component of membrane
.cytoplasmic side of plasma membrane
  + 5 more...
4 EBI-6083058,EBI-517684 GAB1  
  .interleukin-6-mediated signaling pathway
.labyrinthine layer development
.phosphatidylinositol-mediated signaling
  + 13 more...
.SH3/SH2 adaptor activity
.signal transducer activity
.cytosol
5 EBI-6083058,EBI-10192441 FAM134C  
  .N/A .N/A .integral component of membrane
6 EBI-6083058,EBI-346595 SH3KBP1  
  .negative regulation of epidermal growth factor receptor signaling pathway
.cell migration
.regulation of cell shape
  + 5 more...
.N/A .synapse
.neuron projection
.cytoplasmic vesicle membrane
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood40
bone marrow41
connective tissue33
kidney61
lung2
lymph112
lymph node77
prostate15
spleen18
testis2
thymus12
tonsil176
uterus4
Health State
TissuesTPM*
normal4
chondrosarcoma24
leukemia42
lymphoma193
prostate cancer28
soft tissue/muscle tissue tumor23
uterine tumor11
Developmental Stage
TissuesTPM*
adult8
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
appendix15.9
bone marrow2.9
colon2
duodenum1.7
gallbladder1.7
kidney9.2
lung1.3
lymph node40.4
small intestine1.5
spleen16.2
stomach2.6
testis2.5
urinary bladder3.1
Tissues
TissuesExpression level
appendixMedium
bone marrowLow
breastLow
bronchusLow
cerebellumMedium
cervix, uterineLow
colonLow
duodenumMedium
endometrium 1Low
endometrium 2Medium
epididymisLow
fallopian tubeMedium
gallbladderLow
heart muscleLow
kidneyMedium
lateral ventricleLow
lungLow
lymph nodeHigh
pancreasMedium
rectumMedium
seminal vesicleMedium
skeletal muscleMedium
skin 1Medium
small intestineMedium
soft tissue 1Low
spleenMedium
stomach 1Medium
stomach 2Medium
testisLow
tonsilHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604298, gene) Signal transducing adaptor family member 1; STAP1OMIM


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