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> Protein (NX_Q9UMN6)
Protein (NX_Q9UMN6)
Protein
Gene SymbolKMT2B to neXtProt (NX_Q9UMN6)
DescriptionHistone-lysine N-methyltransferase 2B
Chromosome19
Location19q13.12 (36208921 ~ 36229779) to Ensembl
Sequene Features : Isoforms 2, Variants 63, PTMs 22 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.histone H3-K4 trimethylation
.regulation of histone H3-K4 methylation
.histone H3-K4 methylation
  + 7 more...
.histone methyltransferase activity (H3-K4 specific)
.zinc ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.histone methyltransferase complex
.nucleoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 63 22
2014-09-19protein level
2 63 22
2014-05-27protein level
2 63 23
2014-02-25protein level
2 187 23
2013-12-09protein level
2 143 23
2013-11-01protein level
2 141 21
2013-09-12protein level
2 141 22
2013-08-17protein level
2 142 22
2013-07-15protein level
2 72 21
2013-06-11protein level
2 72 21
2013-02-12protein level
2 26 26
2012-12-20protein level
2 26 26
2012-10-30protein level
2 36 26
2012-10-07protein level
2 36 20
2012-08-24protein level
2 35 20
2012-07-28protein level
2 35 20
2012-06-08protein level
2 43 20
2012-05-07protein level
2 33 20
2012-04-10protein level
2 33 20
2012-01-13protein level
2 25 20
2011-12-20protein level
2 25 20
2011-11-11protein level
2 25 20
2011-08-23protein level
2 25 20
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9UMN6-1
92 20 5 293329.3948
NX_Q9UMN6-2
2 20 0 61523.7025
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-765774,EBI-389883 NCK1  
  .negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.negative regulation of PERK-mediated unfolded protein response
  + 23 more...
.eukaryotic initiation factor eIF2 binding
.receptor tyrosine kinase binding
.protein binding, bridging
  + 5 more...
.vesicle membrane
.cell-cell junction
.plasma membrane
  + 6 more...
2 EBI-765774,EBI-540834 WDR5  
  .histone H3-K4 methylation
.histone H4-K16 acetylation
.histone H4-K8 acetylation
  + 6 more...
.N/A .MLL1 complex
.Set1C/COMPASS complex
.histone methyltransferase complex
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites75
blood73
bone41
brain26
connective tissue33
embryonic tissue70
eye47
heart33
intestine25
kidney14
larynx127
liver24
lung35
lymph node77
mammary gland19
mouth15
muscle9
nerve64
ovary59
pancreas37
pituitary gland60
placenta28
prostate15
skin42
spleen56
testis48
thymus37
thyroid21
umbilical cord72
uterus12
Health State
TissuesTPM*
normal32
adrenal tumor79
bladder carcinoma56
breast (mammary gland) tumor21
chondrosarcoma84
colorectal tumor44
gastrointestinal tumor25
germ cell tumor45
glioma65
head and neck tumor44
kidney tumor43
leukemia84
liver tumor31
lung tumor48
lymphoma13
non-neoplasia20
ovarian tumor52
pancreatic tumor9
primitive neuroectodermal tumor of the CNS39
prostate cancer19
retinoblastoma43
skin tumor47
soft tissue/muscle tissue tumor7
uterine tumor33
Developmental Stage
TissuesTPM*
adult38
embryoid body85
blastocyst97
neonate32
fetus32
infant42
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Disease
No.Disease DescriptionRef.
1(*606834, gene) Myeloid/lymphoid or mixed-lineage leukemia 4OMIM


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