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> Protein (NX_Q9UMS0)
Protein (NX_Q9UMS0)
Protein
Gene SymbolNFU1 to neXtProt (NX_Q9UMS0)
DescriptionNFU1 iron-sulfur cluster scaffold homolog, mitochondrial
Chromosome2
Location2p13.3 (69622882 ~ 69664760) to Ensembl
Sequene Features : Isoforms 3, Variants 24, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.iron-sulfur cluster assembly .4 iron, 4 sulfur cluster binding
.iron ion binding
.cytosol
.mitochondrion
.cytoplasm
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 24 1
2014-09-19protein level
3 20 1
2014-05-27protein level
3 20 1
2014-02-25protein level
3 20 0
2013-12-09protein level
3 17 0
2013-11-01protein level
3 16 0
2013-09-12protein level
3 16 0
2013-08-17protein level
3 16 0
2013-07-15protein level
3 12 0
2013-06-11protein level
3 12 0
2013-02-12protein level
3 5 0
2012-12-20protein level
3 5 0
2012-10-30protein level
3 5 0
2012-10-07protein level
3 5 0
2012-08-24protein level
3 4 0
2012-07-28protein level
3 4 0
2012-06-08protein level
3 5 0
2012-05-07protein level
3 5 0
2012-04-10protein level
3 5 0
2012-01-13protein level
3 6 0
2011-12-20protein level
3 5 0
2011-11-11protein level
3 5 0
2011-08-23protein level
3 5 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9UMS0-1
1 10 0 28444.2842
NX_Q9UMS0-2
1 4 0 12338.838
NX_Q9UMS0-3
0 10 0 25906.9687
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-725252,EBI-740098 TRIM23  
  .positive regulation of catalytic activity
.protein ubiquitination
.viral process
.small GTPase mediated signal transduction
.identical protein binding
.GDP binding
.ligase activity
  + 5 more...
.extracellular exosome
.lysosomal membrane
.nucleus
.Golgi membrane
2 EBI-725252,EBI-739580 CALCOCO2  
  .response to interferon-gamma
.viral process
.protein homodimerization activity .perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.membrane
  + 4 more...
3 EBI-725252,EBI-741181 AGTRAP  
  .regulation of blood pressure
.response to hypoxia
.angiotensin type II receptor activity .intracellular membrane-bounded organelle
.cytoplasmic vesicle membrane
.integral component of membrane
  + 6 more...
4 EBI-725252,EBI-1105213 TFIP11  
  .biomineral tissue development
.RNA processing
.regulation of transcription, DNA-templated
  + 2 more...
.DNA binding .catalytic step 2 spliceosome
.U2-type post-mRNA release spliceosomal complex
.nuclear speck
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
ascites25
blood32
bone55
brain21
connective tissue53
embryonic tissue23
eye71
heart33
intestine38
kidney33
liver4
lung38
lymph22
lymph node22
mammary gland6
mouth181
muscle47
nerve64
ovary19
pancreas74
placenta21
prostate10
skin9
stomach62
testis20
uterus30
vascular19
Health State
TissuesTPM*
normal26
breast (mammary gland) tumor10
chondrosarcoma48
colorectal tumor44
gastrointestinal tumor50
germ cell tumor26
glioma27
head and neck tumor89
kidney tumor14
leukemia42
liver tumor10
lung tumor19
lymphoma13
primitive neuroectodermal tumor of the CNS31
prostate cancer19
retinoblastoma64
skin tumor7
soft tissue/muscle tissue tumor79
uterine tumor22
Developmental Stage
TissuesTPM*
adult36
embryoid body28
blastocyst48
fetus30
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue54.7
adrenal gland45.1
appendix21.3
bone marrow19
cerebral cortex31.2
colon36.2
duodenum23.1
esophagus23.9
gallbladder26.3
heart muscle54.4
kidney50.1
liver21.2
lung26.5
lymph node27
ovary30
pancreas14.8
placenta35
prostate35.4
salivary gland26
skin12.4
small intestine25.5
spleen24.5
stomach26.9
testis30.4
thyroid gland37.9
urinary bladder28.8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#605711, phenotype) Multiple mitochondrial dysfunctions syndrome 1; MMDS1OMIM
2(*608100, gene) Nfu1, s. cerevisiae, homolog of; NFU1OMIM


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