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> Protein (NX_Q9UMX1)
Protein (NX_Q9UMX1)
Protein
Gene SymbolSUFU to neXtProt (NX_Q9UMX1)
DescriptionSuppressor of fused homolog
Chromosome10
Location10q24.32 (104263744 ~ 104393292) to Ensembl
Sequene Features : Isoforms 3, Variants 56, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
.negative regulation of smoothened signaling pathway
  + 15 more...
.protein kinase binding
.transcription factor binding
.signal transducer activity
.transcription corepressor activity
.ciliary base
.ciliary tip
.primary cilium
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 56 3
2014-09-19protein level
3 44 3
2014-05-27protein level
3 44 3
2014-02-25protein level
3 44 3
2013-12-09protein level
3 33 3
2013-11-01protein level
3 29 2
2013-09-12protein level
3 29 2
2013-08-17protein level
3 29 2
2013-07-15protein level
3 23 2
2013-06-11protein level
3 23 2
2013-02-12protein level
3 12 4
2012-12-20protein level
3 13 4
2012-10-30protein level
3 14 4
2012-10-07protein level
3 14 2
2012-08-24protein level
3 13 2
2012-07-28protein level
3 13 2
2012-06-08protein level
3 23 2
2012-05-07protein level
3 19 2
2012-04-10protein level
3 19 2
2012-01-13protein level
3 16 2
2011-12-20protein level
3 16 2
2011-11-11protein level
3 16 2
2011-08-23protein level
3 12 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9UMX1-1
3 18 0 53912.85
NX_Q9UMX1-2
1 18 0 47901.7567
NX_Q9UMX1-3
2 18 0 52943.1573
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-740595,EBI-308084 GLI1  
  .negative regulation of canonical Wnt signaling pathway
.notochord regression
.digestive tract morphogenesis
  + 17 more...
.metal ion binding
.transcription regulatory region DNA binding
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
  + 2 more...
.ciliary base
.ciliary tip
.primary cilium
  + 5 more...
2 EBI-740595,EBI-308055 GLI3  
  .negative regulation of canonical Wnt signaling pathway
.thymocyte apoptotic process
.cell differentiation involved in kidney development
  + 58 more...
.metal ion binding
.histone deacetylase binding
.histone acetyltransferase binding
  + 5 more...
.ciliary base
.ciliary tip
.primary cilium
  + 7 more...
3 EBI-740595,EBI-752057 PEX26  
  .protein import into peroxisome membrane
.protein import into peroxisome matrix
.ATPase binding
.protein complex binding
.protein C-terminus binding
.integral component of peroxisomal membrane
.peroxisome
4 EBI-740595,EBI-746283 RCN3  
  .N/A .calcium ion binding .endoplasmic reticulum lumen
5 EBI-740595,EBI-4395497 ZNF747  
  .regulation of transcription, DNA-templated .nucleic acid binding .intracellular
6 EBI-740595,EBI-863797 STK36  
  .regulation of sequence-specific DNA binding transcription factor activity
.positive regulation of smoothened signaling pathway
.cilium assembly
  + 5 more...
.transcription factor binding
.ATP binding
.protein serine/threonine kinase activity
.magnesium ion binding
.cytoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood8
bone55
bone marrow20
brain37
connective tissue13
ear62
embryonic tissue32
eye9
heart44
intestine17
kidney23
liver29
lung35
lymph node89
mammary gland39
mouth45
muscle75
ovary39
pancreas9
placenta14
prostate42
skin14
spleen74
testis29
thymus62
thyroid21
trachea19
umbilical cord72
uterus73
vascular19
Health State
TissuesTPM*
normal30
breast (mammary gland) tumor64
chondrosarcoma60
colorectal tumor8
germ cell tumor53
glioma74
head and neck tumor22
kidney tumor14
leukemia21
liver tumor52
lung tumor19
lymphoma13
non-neoplasia10
pancreatic tumor9
primitive neuroectodermal tumor of the CNS7
prostate cancer48
skin tumor15
soft tissue/muscle tissue tumor71
uterine tumor99
Developmental Stage
TissuesTPM*
adult23
embryoid body28
blastocyst32
neonate32
fetus39
infant42
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue4.7
adrenal gland4.7
appendix6.7
bone marrow1.2
cerebral cortex5.5
colon3.9
duodenum3.4
esophagus6.1
gallbladder7.1
heart muscle4.6
kidney5.4
liver2.2
lung5.8
lymph node7
ovary8.8
pancreas1.7
placenta6.1
prostate7.2
salivary gland4.8
skin10.3
small intestine3.9
spleen7
stomach3.5
testis8.2
thyroid gland2.3
urinary bladder7.5
Tissues
TissuesExpression level
adrenal glandHigh
appendixMedium
bone marrowLow
breastHigh
bronchusMedium
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderHigh
heart muscleMedium
hippocampusMedium
kidneyMedium
lateral ventricleMedium
liverLow
lungLow
lymph nodeMedium
nasopharynxHigh
oral mucosaMedium
ovaryLow
pancreasMedium
parathyroid glandMedium
placentaHigh
prostateMedium
rectumHigh
salivary glandLow
seminal vesicleMedium
skeletal muscleMedium
skin 1High
skin 2Medium
small intestineMedium
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Medium
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#155255, phenotype) Medulloblastoma; MDBOMIM
2(*607035, gene) Suppressor of fused, drosophila, homolog of; SUFUOMIM
3medulloblastoma;Medulloblastoma predispositionCGP


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