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> Protein (NX_Q9UNA4)
Protein (NX_Q9UNA4)
Protein
Gene SymbolPOLI to neXtProt (NX_Q9UNA4)
DescriptionDNA polymerase iota
Chromosome18
Location18q21.2 (51795774 ~ 51847636) to Ensembl
Sequene Features : Isoforms 1, Variants 105, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.error-prone translesion synthesis
.translesion synthesis
.DNA repair
.DNA replication
.metal ion binding
.DNA-directed DNA polymerase activity
.damaged DNA binding
.intracellular membrane-bounded organelle
.nucleoplasm
.nucleus
.intracellular
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 105 6
2014-09-19protein level
1 91 6
2014-05-27protein level
1 91 6
2014-02-25protein level
1 91 6
2013-12-09protein level
1 67 6
2013-11-01protein level
1 66 3
2013-09-12protein level
1 66 3
2013-08-17protein level
1 66 3
2013-07-15protein level
1 52 0
2013-06-11protein level
1 52 0
2013-02-12protein level
1 30 0
2012-12-20protein level
1 30 0
2012-10-30protein level
1 36 0
2012-10-07protein level
1 36 0
2012-08-24protein level
1 36 0
2012-07-28protein level
1 36 0
2012-06-08protein level
1 40 0
2012-05-07protein level
1 32 0
2012-04-10protein level
1 32 0
2012-01-13protein level
1 21 0
2011-12-20protein level
1 21 0
2011-11-11protein level
1 21 0
2011-08-23protein level
1 21 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9UNA4-1
37 0 0 82953.406
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-741774,EBI-3390054 UBC  
  .programmed necrotic cell death
.apoptotic signaling pathway
.energy homeostasis
  + 90 more...
.poly(A) RNA binding
.protease binding
.extracellular exosome
.endocytic vesicle membrane
.endosome membrane
  + 3 more...
2 EBI-741774,EBI-947466 XRCC1  
  .response to drug
.hippocampus development
.response to organic substance
  + 4 more...
.enzyme binding
.damaged DNA binding
.nucleoplasm
.nucleus
3 EBI-741774,EBI-724310 DAZAP2  
  .N/A .WW domain binding .cytoplasm
.nucleus
4 EBI-741774,EBI-5658292 ZBTB44  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
5 EBI-741774,EBI-9675724 TMEM239  
  .N/A .N/A .integral component of membrane
6 EBI-741774,EBI-739510 TRIM39  
  .positive regulation of apoptotic signaling pathway
.negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.protein ubiquitination
.apoptotic process
.identical protein binding
.ligase activity
.zinc ion binding
.cytosol
.mitochondrion
7 EBI-741774,EBI-359276 TRAF6  
  .positive regulation of transcription regulatory region DNA binding
.apoptotic signaling pathway
.cellular response to lipopolysaccharide
  + 61 more...
.protein N-terminus binding
.protein kinase B binding
.histone deacetylase binding
  + 10 more...
.perinuclear region of cytoplasm
.protein complex
.CD40 receptor complex
  + 10 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites25
blood16
bone41
brain17
connective tissue26
ear62
embryonic tissue84
eye23
heart33
intestine17
kidney9
liver4
lung23
lymph node33
mammary gland26
muscle37
nerve64
ovary9
pancreas37
parathyroid97
placenta77
prostate21
skin14
spleen18
testis39
thymus37
trachea38
umbilical cord72
uterus47
Health State
TissuesTPM*
normal33
breast (mammary gland) tumor21
chondrosarcoma60
colorectal tumor26
gastrointestinal tumor16
germ cell tumor11
glioma9
kidney tumor14
leukemia10
lung tumor19
non-neoplasia10
ovarian tumor13
pancreatic tumor38
primitive neuroectodermal tumor of the CNS7
prostate cancer19
retinoblastoma43
skin tumor15
soft tissue/muscle tissue tumor15
uterine tumor66
Developmental Stage
TissuesTPM*
adult32
embryoid body114
blastocyst48
neonate64
fetus32
infant42
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue25.2
adrenal gland15.4
appendix14.9
bone marrow10.2
cerebral cortex11.6
colon8.4
duodenum12.6
esophagus10
gallbladder14.8
heart muscle11.8
kidney17.8
liver5.4
lung17.4
lymph node18
ovary25.7
pancreas10.3
placenta23.9
prostate26.7
salivary gland13.5
skin11.5
small intestine11.7
spleen16.8
stomach14.2
testis46.1
thyroid gland44.5
urinary bladder15.1
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*605252, gene) Polymerase, dna, iota; POLIOMIM


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