Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_Q9UNH7)
Protein (NX_Q9UNH7)
Protein
Gene SymbolSNX6 to neXtProt (NX_Q9UNH7)
DescriptionSorting nexin-6
Chromosome14
Location14q13.1 (35030300 ~ 35099389) to Ensembl
Sequene Features : Isoforms 2, Variants 19, PTMs 11 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of transcription, DNA-templated
.retrograde transport, endosome to Golgi
.negative regulation of transforming growth factor beta receptor signaling pathway
  + 4 more...
.protein homodimerization activity
.phosphatidylinositol binding
.dynactin binding
.tubular endosome
.early endosome membrane
.retromer complex
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 19 11
2014-09-19protein level
2 14 11
2014-05-27protein level
2 14 12
2014-02-25protein level
2 14 12
2013-12-09protein level
2 12 12
2013-11-01protein level
2 11 8
2013-09-12protein level
2 11 8
2013-08-17protein level
2 11 8
2013-07-15protein level
2 5 2
2013-06-11protein level
2 5 2
2013-02-12protein level
2 1 0
2012-12-20protein level
1 1 0
2012-10-30protein level
1 2 0
2012-10-07protein level
1 2 0
2012-08-24protein level
1 3 0
2012-07-28protein level
1 3 0
2012-06-08protein level
1 6 0
2012-05-07protein level
1 5 0
2012-04-10protein level
1 5 0
2012-01-13protein level
1 3 0
2011-12-20protein level
1 3 0
2011-11-11protein level
1 3 0
2011-08-23protein level
1 3 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9UNH7-1
4 13 2 46619.6229
NX_Q9UNH7-2
0 13 1 33549.2854
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-949294,EBI-748974 OPTN  
  .Golgi ribbon formation
.defense response to Gram-negative bacterium
.negative regulation of I-kappaB kinase/NF-kappaB signaling
  + 10 more...
.K63-linked polyubiquitin binding
.identical protein binding
.polyubiquitin binding
  + 2 more...
.recycling endosome
.perinuclear region of cytoplasm
.cytoplasmic membrane-bounded vesicle
  + 8 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland60
ascites125
bladder200
blood81
bone83
bone marrow164
brain98
cervix123
connective tissue167
embryonic tissue103
esophagus297
eye62
heart67
intestine47
kidney90
liver126
lung47
lymph22
lymph node44
mammary gland39
mouth105
muscle37
nerve128
ovary49
pancreas28
parathyroid631
pharynx98
pituitary gland121
placenta201
prostate21
skin75
spleen56
stomach73
testis114
thymus200
thyroid42
umbilical cord72
uterus86
vascular38
Health State
TissuesTPM*
normal94
adrenal tumor79
bladder carcinoma56
breast (mammary gland) tumor32
cervical tumor173
chondrosarcoma193
colorectal tumor53
esophageal tumor347
gastrointestinal tumor59
germ cell tumor94
glioma18
head and neck tumor67
kidney tumor72
leukemia52
liver tumor145
lung tumor38
lymphoma55
non-neoplasia93
ovarian tumor65
pancreatic tumor19
primitive neuroectodermal tumor of the CNS102
prostate cancer28
retinoblastoma86
skin tumor15
soft tissue/muscle tissue tumor103
uterine tumor33
Developmental Stage
TissuesTPM*
adult92
embryoid body142
blastocyst97
neonate160
fetus80
infant42
juvenile125
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue51.8
adrenal gland49.5
appendix63.7
bone marrow30.8
cerebral cortex33.1
colon60.3
duodenum82.4
esophagus54.9
gallbladder56.3
heart muscle40.2
kidney46.7
liver22.8
lung38
lymph node71.4
ovary38.5
pancreas15.7
placenta87.5
prostate32.6
salivary gland28
skin30.9
small intestine55.8
spleen49.7
stomach42.5
testis50.5
thyroid gland48.9
urinary bladder80.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*606098, gene) Sorting nexin 6; SNX6OMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center