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> Protein (NX_Q9UNQ0)
Protein (NX_Q9UNQ0)
Protein
Gene SymbolABCG2 to neXtProt (NX_Q9UNQ0)
DescriptionATP-binding cassette sub-family G member 2
Chromosome4
Location4q22.1 (89011416 ~ 89152474) to Ensembl
Sequene Features : Isoforms 2, Variants 127, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.transmembrane transport
.urate metabolic process
.small molecule metabolic process
  + 6 more...
.protein homodimerization activity
.ATPase activity, coupled to transmembrane movement of substances
.heme transporter activity
  + 3 more...
.mitochondrial membrane
.integral component of membrane
.plasma membrane
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 127 3
2014-09-19protein level
2 105 3
2014-05-27protein level
2 104 3
2014-02-25protein level
2 104 3
2013-12-09protein level
2 82 3
2013-11-01protein level
2 76 3
2013-09-12protein level
2 76 3
2013-08-17protein level
2 76 3
2013-07-15protein level
2 53 3
2013-06-11protein level
2 53 3
2013-02-12protein level
2 31 3
2012-12-20protein level
2 31 3
2012-10-30protein level
2 38 3
2012-10-07protein level
2 38 3
2012-08-24protein level
2 29 3
2012-07-28protein level
2 29 3
2012-06-08protein level
2 44 3
2012-05-07protein level
2 44 3
2012-04-10protein level
2 41 3
2012-01-13protein level
2 35 3
2011-12-20protein level
2 35 3
2011-11-11protein level
2 35 3
2011-08-23protein level
2 35 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9UNQ0-1
4 25 0 72267.2795
NX_Q9UNQ0-2
3 25 0 67409.5102
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1569435,EBI-3390054 UBC  
  .programmed necrotic cell death
.apoptotic signaling pathway
.energy homeostasis
  + 90 more...
.poly(A) RNA binding
.protease binding
.extracellular exosome
.endocytic vesicle membrane
.endosome membrane
  + 3 more...
2 EBI-1569435,EBI-1018629 PIM1  
  .vitamin D receptor signaling pathway
.protein autophosphorylation
.negative regulation of sequence-specific DNA binding transcription factor activity
  + 9 more...
.ribosomal small subunit binding
.manganese ion binding
.transcription factor binding
  + 2 more...
.plasma membrane
.cytoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder66
brain62
connective tissue6
ear62
embryonic tissue14
intestine38
kidney9
liver4
lung2
mouth15
muscle9
pancreas9
pharynx73
placenta84
prostate47
skin4
stomach10
testis22
thyroid21
trachea19
uterus38
vascular19
Health State
TissuesTPM*
normal39
bladder carcinoma113
colorectal tumor8
germ cell tumor49
head and neck tumor14
kidney tumor14
liver tumor10
non-neoplasia41
pancreatic tumor9
prostate cancer9
skin tumor7
soft tissue/muscle tissue tumor7
uterine tumor33
Developmental Stage
TissuesTPM*
adult27
blastocyst16
fetus41
infant42
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue1.6
adrenal gland4.2
appendix1.4
bone marrow1.9
cerebral cortex17
colon20.5
duodenum49.5
esophagus2.6
gallbladder8
heart muscle5.1
kidney3.4
liver16.3
lung7.9
lymph node1.5
ovary9.1
placenta14.4
prostate7.1
salivary gland4.5
small intestine93
spleen2
stomach3
testis4.3
thyroid gland9.1
urinary bladder3.5
Tissues
TissuesExpression level
adrenal glandMedium
cerebral cortexHigh
colonMedium
duodenumMedium
heart muscleMedium
kidneyLow
lungLow
placentaMedium
rectumMedium
seminal vesicleHigh
skeletal muscleLow
small intestineMedium
smooth muscleMedium
testisLow
thyroid glandLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#138900, phenotype) Uric acid concentration, serum, quantitative trait locus 1; UAQTL1OMIM
2(*603756, gene) Atp-binding cassette, subfamily g, member 2; ABCG2OMIM
3(#614490, phenotype) Blood group, junior system; JROMIM


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