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	> Protein (NX_Q9UPN9) Protein (NX_Q9UPN9) Protein Gene Symbol TRIM33 to neXtProt (NX_Q9UPN9) Description E3 ubiquitin-protein ligase TRIM33 Chromosome 1 Location 1p13.2 (114935399 ~ 115053781) to Ensembl Sequene Features : Isoforms 2, Variants 98, PTMs 22 to neXtProt Sequence Features Gene Ontologies GO: Biological Process GO: Mulecular Function GO: Cellular Component .negative regulation of transcription, DNA-templated .negative regulation of BMP signaling pathway .regulation of transforming growth factor beta receptor signaling pathway   + 6 more... .R-SMAD binding .co-SMAD binding .ligase activity   + 3 more... .intracellular membrane-bounded organelle .nucleoplasm .nucleus Proteomic Evidences Release Protein Evidence Pr Ab Isoforms Variants PTMs 2015-01-01 protein level 2 98 22 2014-09-19 protein level 2 78 22 2014-05-27 protein level 2 78 22 2014-02-25 protein level 2 76 16 2013-12-09 protein level 2 69 16 2013-11-01 protein level 2 68 14 2013-09-12 protein level 2 68 14 2013-08-17 protein level 2 68 14 2013-07-15 protein level 2 40 13 2013-06-11 protein level 2 40 13 2013-02-12 protein level 2 21 26 2012-12-20 protein level 2 21 26 2012-10-30 protein level 2 25 26 2012-10-07 protein level 2 25 13 2012-08-24 protein level 2 13 13 2012-07-28 protein level 2 13 13 2012-06-08 protein level 2 19 13 2012-05-07 protein level 2 19 13 2012-04-10 protein level 2 19 13 2012-01-13 protein level 2 22 13 2011-12-20 protein level 2 22 13 2011-11-11 protein level 2 22 10 2011-08-23 protein level 2 22 10 Protein Isoforms Isoform Ac   U G S Mw (Da) NX_Q9UPN9-1 2 48 1 122455.3657 NX_Q9UPN9-2 1 48 1 120464.3493 : Uniquely mapped peptide : Gene-specific peptide : Shared peptide Interacting Partners No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component 1 EBI-2214398,EBI-347263 SMAD4     .nephrogenic mesenchyme morphogenesis .metanephric mesenchyme morphogenesis .response to transforming growth factor beta   + 49 more... .R-SMAD binding .I-SMAD binding .metal ion binding   + 9 more... .SMAD protein complex .activin responsive factor complex .cytosol   + 6 more... 2 EBI-2214398,EBI-1040141 SMAD2     .positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry .response to cholesterol .SMAD protein signal transduction   + 42 more... .R-SMAD binding .I-SMAD binding .co-SMAD binding   + 15 more... .SMAD2-SMAD3 protein complex .SMAD protein complex .activin responsive factor complex   + 6 more... EST expression level of Protein Coding Gene (ref. NCBI UniGene EST) Body Sites Tissues TPM* ascites 25 bladder 167 blood 49 bone 41 bone marrow 61 brain 44 cervix 144 connective tissue 80 ear 62 embryonic tissue 98 eye 90 heart 22 intestine 77 kidney 61 larynx 383 liver 53 lung 62 lymph node 189 mammary gland 152 muscle 75 ovary 29 pancreas 65 parathyroid 48 placenta 113 prostate 89 salivary gland 296 skin 156 spleen 18 stomach 31 testis 193 thymus 87 thyroid 128 trachea 57 uterus 116 vascular 96 Health State Tissues TPM* normal 85 bladder carcinoma 56 breast (mammary gland) tumor 139 cervical tumor 173 chondrosarcoma 48 colorectal tumor 106 gastrointestinal tumor 42 germ cell tumor 56 glioma 27 head and neck tumor 82 kidney tumor 29 leukemia 74 liver tumor 83 lung tumor 9 lymphoma 13 non-neoplasia 103 ovarian tumor 26 primitive neuroectodermal tumor of the CNS 23 prostate cancer 38 retinoblastoma 129 skin tumor 183 soft tissue/muscle tissue tumor 111 uterine tumor 144 Developmental Stage Tissues TPM* adult 99 embryoid body 100 blastocyst 65 fetus 73 juvenile 35 TPM*: Transcripts per million; transcript expression level measured by expression sequence tags. Expression level of Protein (ref. Human Protein Atlas) RNA-Seq. Tissues FPKM adipose tissue 8.2 adrenal gland 9.3 appendix 14.3 bone marrow 16.5 cerebral cortex 12.2 colon 11 duodenum 8.4 esophagus 12.2 gallbladder 12.8 heart muscle 7.3 kidney 13 liver 7.4 lung 11.3 lymph node 15.1 ovary 15.3 pancreas 6.2 placenta 17.2 prostate 16 salivary gland 9 skin 14.8 small intestine 8.8 spleen 13.8 stomach 11.9 testis 28.7 thyroid gland 15.8 urinary bladder 12.6 Tissues Tissues Expression level adrenal gland High appendix Medium bone marrow High breast Medium bronchus Medium cerebellum High cerebral cortex High cervix, uterine Medium colon Medium duodenum Medium endometrium 1 Medium endometrium 2 High epididymis Medium esophagus Medium fallopian tube Medium gallbladder High heart muscle Low hippocampus High kidney Medium lateral ventricle Medium lung Medium lymph node Medium nasopharynx Medium oral mucosa Medium ovary Medium pancreas High parathyroid gland Medium placenta High prostate Medium rectum Medium salivary gland Medium seminal vesicle Low skin 1 Medium skin 2 High small intestine Medium smooth muscle Low soft tissue 1 Medium soft tissue 2 Medium spleen Low stomach 1 Medium stomach 2 Medium testis Medium thyroid gland High tonsil High urinary bladder High vagina Medium Cancer Tumor Number of patients and Staining levels breast cancer carcinoid cervical cancer colorectal cancer endometrial cancer glioma head and neck cancer liver cancer lung cancer lymphoma melanoma ovarian cancer pancreatic cancer prostate cancer renal cancer skin cancer stomach cancer testis cancer thyroid cancer urothelial cancer RNA-seq colour codes Highly expressed RNAs (FPKM >50) Moderately expressed RNAs (50> FPKM >10) Lower expressed RNAs (10> FPKM >1) The lowest expressed RNAs (FPKM value of 0 or 1) Expression level colour codes Highly expressed protein Moderately expressed protein Lower expressed protein Staining level colour codes Highly expressed protein Moderately expressed protein Lower expressed protein Not Detected Disease No. Disease Description Ref. 1 (#188550, phenotype) Thyroid carcinoma, papillary OMIM 2 (*605769, gene) Tripartite motif-containing protein 33; TRIM33 OMIM 3 papillary thyroid CGP

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