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Protein |
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Gene Symbol | TRIM33 to neXtProt (NX_Q9UPN9) |
Description | E3 ubiquitin-protein ligase TRIM33 |
Chromosome | 1 |
Location | 1p13.2 (114935399 ~ 115053781) to Ensembl |
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Sequene Features : Isoforms 2, Variants 98, PTMs 22 to neXtProt Sequence Features
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Gene Ontologies |
GO: Biological Process |
GO: Mulecular Function |
GO: Cellular Component |
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.negative regulation of transcription, DNA-templated .negative regulation of BMP signaling pathway .regulation of transforming growth factor beta receptor signaling pathway + 6 more... |
.R-SMAD binding .co-SMAD binding .ligase activity + 3 more... |
.intracellular membrane-bounded organelle .nucleoplasm .nucleus |
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Proteomic Evidences |
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Release | | Protein Evidence | | Pr | | Ab | | Isoforms | | Variants | | PTMs |
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2015-01-01 | | protein level | | | | | | | 2 |
| 98 |
| 22 |
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2014-09-19 | | protein level | | | | | | | 2 |
| 78 |
| 22 |
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2014-05-27 | | protein level | | | | | | | 2 |
| 78 |
| 22 |
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2014-02-25 | | protein level | | | | | | | 2 |
| 76 |
| 16 |
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2013-12-09 | | protein level | | | | | | | 2 |
| 69 |
| 16 |
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2013-11-01 | | protein level | | | | | | | 2 |
| 68 |
| 14 |
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2013-09-12 | | protein level | | | | | | | 2 |
| 68 |
| 14 |
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2013-08-17 | | protein level | | | | | | | 2 |
| 68 |
| 14 |
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2013-07-15 | | protein level | | | | | | | 2 |
| 40 |
| 13 |
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2013-06-11 | | protein level | | | | | | | 2 |
| 40 |
| 13 |
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2013-02-12 | | protein level | | | | | | | 2 |
| 21 |
| 26 |
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2012-12-20 | | protein level | | | | | | | 2 |
| 21 |
| 26 |
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2012-10-30 | | protein level | | | | | | | 2 |
| 25 |
| 26 |
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2012-10-07 | | protein level | | | | | | | 2 |
| 25 |
| 13 |
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2012-08-24 | | protein level | | | | | | | 2 |
| 13 |
| 13 |
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2012-07-28 | | protein level | | | | | | | 2 |
| 13 |
| 13 |
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2012-06-08 | | protein level | | | | | | | 2 |
| 19 |
| 13 |
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2012-05-07 | | protein level | | | | | | | 2 |
| 19 |
| 13 |
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2012-04-10 | | protein level | | | | | | | 2 |
| 19 |
| 13 |
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2012-01-13 | | protein level | | | | | | | 2 |
| 22 |
| 13 |
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2011-12-20 | | protein level | | | | | | | 2 |
| 22 |
| 13 |
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2011-11-11 | | protein level | | | | | | | 2 |
| 22 |
| 10 |
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2011-08-23 | | protein level | | | | | | | 2 |
| 22 |
| 10 |
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Protein Isoforms |
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| : Uniquely mapped peptide | | : Gene-specific peptide | | : Shared peptide |
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Interacting Partners |
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No. |
Exp. ref. |
Symbol |
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PE |
Pr |
Ab |
Di |
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GO: Biological Process |
GO: Mulecular Function |
GO: Cellular Component |
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1 |
EBI-2214398,EBI-347263 |
SMAD4 |
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.nephrogenic mesenchyme morphogenesis .metanephric mesenchyme morphogenesis .response to transforming growth factor beta + 49 more... |
.R-SMAD binding .I-SMAD binding .metal ion binding + 9 more... |
.SMAD protein complex .activin responsive factor complex .cytosol + 6 more... |
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2 |
EBI-2214398,EBI-1040141 |
SMAD2 |
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.positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry .response to cholesterol .SMAD protein signal transduction + 42 more... |
.R-SMAD binding .I-SMAD binding .co-SMAD binding + 15 more... |
.SMAD2-SMAD3 protein complex .SMAD protein complex .activin responsive factor complex + 6 more... |
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EST expression level of Protein Coding Gene (ref. NCBI UniGene EST) |
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Body Sites | |
Tissues | TPM* | |
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ascites | 25 | |
bladder | 167 | |
blood | 49 | |
bone | 41 | |
bone marrow | 61 | |
brain | 44 | |
cervix | 144 | |
connective tissue | 80 | |
ear | 62 | |
embryonic tissue | 98 | |
eye | 90 | |
heart | 22 | |
intestine | 77 | |
kidney | 61 | |
larynx | 383 | |
liver | 53 | |
lung | 62 | |
lymph node | 189 | |
mammary gland | 152 | |
muscle | 75 | |
ovary | 29 | |
pancreas | 65 | |
parathyroid | 48 | |
placenta | 113 | |
prostate | 89 | |
salivary gland | 296 | |
skin | 156 | |
spleen | 18 | |
stomach | 31 | |
testis | 193 | |
thymus | 87 | |
thyroid | 128 | |
trachea | 57 | |
uterus | 116 | |
vascular | 96 | |
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Health State | |
Tissues | TPM* | |
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normal | 85 | |
bladder carcinoma | 56 | |
breast (mammary gland) tumor | 139 | |
cervical tumor | 173 | |
chondrosarcoma | 48 | |
colorectal tumor | 106 | |
gastrointestinal tumor | 42 | |
germ cell tumor | 56 | |
glioma | 27 | |
head and neck tumor | 82 | |
kidney tumor | 29 | |
leukemia | 74 | |
liver tumor | 83 | |
lung tumor | 9 | |
lymphoma | 13 | |
non-neoplasia | 103 | |
ovarian tumor | 26 | |
primitive neuroectodermal tumor of the CNS | 23 | |
prostate cancer | 38 | |
retinoblastoma | 129 | |
skin tumor | 183 | |
soft tissue/muscle tissue tumor | 111 | |
uterine tumor | 144 | |
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Developmental Stage | |
Tissues | TPM* | |
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adult | 99 | |
embryoid body | 100 | |
blastocyst | 65 | |
fetus | 73 | |
juvenile | 35 | |
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TPM*: Transcripts per million; transcript expression level measured by expression sequence tags. |
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Expression level of Protein (ref. Human Protein Atlas) |
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RNA-Seq. | |
Tissues | FPKM | |
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adipose tissue | 8.2 | |
adrenal gland | 9.3 | |
appendix | 14.3 | |
bone marrow | 16.5 | |
cerebral cortex | 12.2 | |
colon | 11 | |
duodenum | 8.4 | |
esophagus | 12.2 | |
gallbladder | 12.8 | |
heart muscle | 7.3 | |
kidney | 13 | |
liver | 7.4 | |
lung | 11.3 | |
lymph node | 15.1 | |
ovary | 15.3 | |
pancreas | 6.2 | |
placenta | 17.2 | |
prostate | 16 | |
salivary gland | 9 | |
skin | 14.8 | |
small intestine | 8.8 | |
spleen | 13.8 | |
stomach | 11.9 | |
testis | 28.7 | |
thyroid gland | 15.8 | |
urinary bladder | 12.6 | |
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Tissues | |
Tissues | Expression level |
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adrenal gland | High | |
appendix | Medium | |
bone marrow | High | |
breast | Medium | |
bronchus | Medium | |
cerebellum | High | |
cerebral cortex | High | |
cervix, uterine | Medium | |
colon | Medium | |
duodenum | Medium | |
endometrium 1 | Medium | |
endometrium 2 | High | |
epididymis | Medium | |
esophagus | Medium | |
fallopian tube | Medium | |
gallbladder | High | |
heart muscle | Low | |
hippocampus | High | |
kidney | Medium | |
lateral ventricle | Medium | |
lung | Medium | |
lymph node | Medium | |
nasopharynx | Medium | |
oral mucosa | Medium | |
ovary | Medium | |
pancreas | High | |
parathyroid gland | Medium | |
placenta | High | |
prostate | Medium | |
rectum | Medium | |
salivary gland | Medium | |
seminal vesicle | Low | |
skin 1 | Medium | |
skin 2 | High | |
small intestine | Medium | |
smooth muscle | Low | |
soft tissue 1 | Medium | |
soft tissue 2 | Medium | |
spleen | Low | |
stomach 1 | Medium | |
stomach 2 | Medium | |
testis | Medium | |
thyroid gland | High | |
tonsil | High | |
urinary bladder | High | |
vagina | Medium | |
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Cancer | |
Tumor | Number of patients and Staining levels | |
breast cancer | |
carcinoid | |
cervical cancer | |
colorectal cancer | |
endometrial cancer | |
glioma | |
head and neck cancer | |
liver cancer | |
lung cancer | |
lymphoma | |
melanoma | |
ovarian cancer | |
pancreatic cancer | |
prostate cancer | |
renal cancer | |
skin cancer | |
stomach cancer | |
testis cancer | |
thyroid cancer | |
urothelial cancer | |
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RNA-seq colour codes |
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Highly expressed RNAs (FPKM >50) |
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Moderately expressed RNAs (50> FPKM >10) |
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Lower expressed RNAs (10> FPKM >1) |
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The lowest expressed RNAs (FPKM value of 0 or 1) |
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Expression level colour codes |
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Highly expressed protein |
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Moderately expressed protein |
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Lower expressed protein |
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Staining level colour codes |
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Highly expressed protein |
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Moderately expressed protein |
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Lower expressed protein |
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Not Detected |
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Disease |
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No. | Disease Description | Ref. |
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1 | (#188550, phenotype) Thyroid carcinoma, papillary | OMIM |
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2 | (*605769, gene) Tripartite motif-containing protein 33; TRIM33 | OMIM |
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3 | papillary thyroid | CGP |
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