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> Protein (NX_Q9UPN9)
Protein (NX_Q9UPN9)
Protein
Gene SymbolTRIM33 to neXtProt (NX_Q9UPN9)
DescriptionE3 ubiquitin-protein ligase TRIM33
Chromosome1
Location1p13.2 (114935399 ~ 115053781) to Ensembl
Sequene Features : Isoforms 2, Variants 98, PTMs 22 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of transcription, DNA-templated
.negative regulation of BMP signaling pathway
.regulation of transforming growth factor beta receptor signaling pathway
  + 6 more...
.R-SMAD binding
.co-SMAD binding
.ligase activity
  + 3 more...
.intracellular membrane-bounded organelle
.nucleoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 98 22
2014-09-19protein level
2 78 22
2014-05-27protein level
2 78 22
2014-02-25protein level
2 76 16
2013-12-09protein level
2 69 16
2013-11-01protein level
2 68 14
2013-09-12protein level
2 68 14
2013-08-17protein level
2 68 14
2013-07-15protein level
2 40 13
2013-06-11protein level
2 40 13
2013-02-12protein level
2 21 26
2012-12-20protein level
2 21 26
2012-10-30protein level
2 25 26
2012-10-07protein level
2 25 13
2012-08-24protein level
2 13 13
2012-07-28protein level
2 13 13
2012-06-08protein level
2 19 13
2012-05-07protein level
2 19 13
2012-04-10protein level
2 19 13
2012-01-13protein level
2 22 13
2011-12-20protein level
2 22 13
2011-11-11protein level
2 22 10
2011-08-23protein level
2 22 10
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9UPN9-1
2 48 1 122455.3657
NX_Q9UPN9-2
1 48 1 120464.3493
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2214398,EBI-347263 SMAD4  
  .nephrogenic mesenchyme morphogenesis
.metanephric mesenchyme morphogenesis
.response to transforming growth factor beta
  + 49 more...
.R-SMAD binding
.I-SMAD binding
.metal ion binding
  + 9 more...
.SMAD protein complex
.activin responsive factor complex
.cytosol
  + 6 more...
2 EBI-2214398,EBI-1040141 SMAD2  
  .positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
.response to cholesterol
.SMAD protein signal transduction
  + 42 more...
.R-SMAD binding
.I-SMAD binding
.co-SMAD binding
  + 15 more...
.SMAD2-SMAD3 protein complex
.SMAD protein complex
.activin responsive factor complex
  + 6 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites25
bladder167
blood49
bone41
bone marrow61
brain44
cervix144
connective tissue80
ear62
embryonic tissue98
eye90
heart22
intestine77
kidney61
larynx383
liver53
lung62
lymph node189
mammary gland152
muscle75
ovary29
pancreas65
parathyroid48
placenta113
prostate89
salivary gland296
skin156
spleen18
stomach31
testis193
thymus87
thyroid128
trachea57
uterus116
vascular96
Health State
TissuesTPM*
normal85
bladder carcinoma56
breast (mammary gland) tumor139
cervical tumor173
chondrosarcoma48
colorectal tumor106
gastrointestinal tumor42
germ cell tumor56
glioma27
head and neck tumor82
kidney tumor29
leukemia74
liver tumor83
lung tumor9
lymphoma13
non-neoplasia103
ovarian tumor26
primitive neuroectodermal tumor of the CNS23
prostate cancer38
retinoblastoma129
skin tumor183
soft tissue/muscle tissue tumor111
uterine tumor144
Developmental Stage
TissuesTPM*
adult99
embryoid body100
blastocyst65
fetus73
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue8.2
adrenal gland9.3
appendix14.3
bone marrow16.5
cerebral cortex12.2
colon11
duodenum8.4
esophagus12.2
gallbladder12.8
heart muscle7.3
kidney13
liver7.4
lung11.3
lymph node15.1
ovary15.3
pancreas6.2
placenta17.2
prostate16
salivary gland9
skin14.8
small intestine8.8
spleen13.8
stomach11.9
testis28.7
thyroid gland15.8
urinary bladder12.6
Tissues
TissuesExpression level
adrenal glandHigh
appendixMedium
bone marrowHigh
breastMedium
bronchusMedium
cerebellumHigh
cerebral cortexHigh
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2High
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderHigh
heart muscleLow
hippocampusHigh
kidneyMedium
lateral ventricleMedium
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaMedium
ovaryMedium
pancreasHigh
parathyroid glandMedium
placentaHigh
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleLow
skin 1Medium
skin 2High
small intestineMedium
smooth muscleLow
soft tissue 1Medium
soft tissue 2Medium
spleenLow
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#188550, phenotype) Thyroid carcinoma, papillaryOMIM
2(*605769, gene) Tripartite motif-containing protein 33; TRIM33OMIM
3papillary thyroidCGP


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