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> Protein (NX_Q9UPQ9)
Protein (NX_Q9UPQ9)
Protein
Gene SymbolTNRC6B to neXtProt (NX_Q9UPQ9)
DescriptionTrinucleotide repeat-containing gene 6B protein
Chromosome22
Location22q13.1 (40440821 ~ 40731812) to Ensembl
Sequene Features : Isoforms 3, Variants 146, PTMs 11 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
.phosphatidylinositol-mediated signaling
  + 10 more...
.poly(A) RNA binding
.nucleotide binding
.cytosol
.cytoplasmic mRNA processing body
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 146 11
2014-09-19protein level
3 102 11
2014-05-27protein level
3 102 11
2014-02-25protein level
3 102 10
2013-12-09protein level
3 72 10
2013-11-01protein level
3 70 10
2013-09-12protein level
3 70 10
2013-08-17protein level
3 70 10
2013-07-15protein level
3 35 10
2013-06-11protein level
3 35 10
2013-02-12protein level
3 13 27
2012-12-20protein level
3 12 27
2012-10-30protein level
3 24 27
2012-10-07protein level
3 24 10
2012-08-24protein level
3 24 10
2012-07-28protein level
3 23 10
2012-06-08protein level
3 24 10
2012-05-07protein level
3 21 10
2012-04-10protein level
3 21 10
2012-01-13protein level
3 12 10
2011-12-20protein level
3 12 10
2011-11-11protein level
3 12 5
2011-08-23protein level
3 12 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9UPQ9-1
0 75 0 182702.5905
NX_Q9UPQ9-2
4 34 0 109276.989
NX_Q9UPQ9-3
3 75 0 193882.7277
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-947158,EBI-1222758 CNOT1  
  .regulation of stem cell maintenance
.positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.RNA phosphodiester bond hydrolysis, exonucleolytic
  + 13 more...
.armadillo repeat domain binding
.poly(A) RNA binding
.retinoic acid receptor binding
  + 3 more...
.CCR4-NOT complex
.membrane
.cytosol
  + 4 more...
2 EBI-947158,EBI-81531 PABPC1  
  .negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
.positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
  + 12 more...
.poly(A) RNA binding
.translation activator activity
.poly(U) RNA binding
  + 4 more...
.catalytic step 2 spliceosome
.extracellular exosome
.cytoplasmic ribonucleoprotein granule
  + 7 more...
3 EBI-947158,EBI-2513054 PAN3  
  .RNA phosphodiester bond hydrolysis, exonucleolytic
.positive regulation of cytoplasmic mRNA processing body assembly
.gene expression
  + 4 more...
.metal ion binding
.transferase activity, transferring phosphorus-containing groups
.ATP binding
.PAN complex
.cytosol
.cytoplasmic mRNA processing body
4 EBI-947158,EBI-528269 AGO2  
  .positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.mRNA cleavage involved in gene silencing by siRNA
.RNA phosphodiester bond hydrolysis, endonucleolytic
  + 25 more...
.endoribonuclease activity, cleaving miRNA-paired mRNA
.pre-miRNA binding
.endoribonuclease activity, cleaving siRNA-paired mRNA
  + 12 more...
.RISC-loading complex
.micro-ribonucleoprotein complex
.ribonucleoprotein complex
  + 9 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
blood81
bone41
bone marrow41
brain30
connective tissue46
embryonic tissue28
eye134
heart44
intestine60
kidney37
larynx42
liver58
lung53
lymph22
lymph node155
mammary gland59
mouth75
muscle75
nerve257
ovary29
pancreas32
parathyroid48
pharynx24
pituitary gland181
prostate73
skin28
spleen37
stomach10
testis27
thymus37
thyroid64
trachea19
uterus8
vascular19
Health State
TissuesTPM*
normal54
breast (mammary gland) tumor53
chondrosarcoma48
colorectal tumor62
gastrointestinal tumor8
germ cell tumor37
glioma18
head and neck tumor37
kidney tumor29
leukemia105
liver tumor62
lung tumor29
lymphoma27
non-neoplasia124
ovarian tumor39
pancreatic tumor9
primitive neuroectodermal tumor of the CNS15
prostate cancer77
retinoblastoma21
skin tumor23
soft tissue/muscle tissue tumor15
Developmental Stage
TissuesTPM*
adult60
embryoid body28
blastocyst65
fetus95
infant85
juvenile125
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue2.9
adrenal gland3.5
appendix4.3
bone marrow10.7
cerebral cortex3.1
colon4.9
duodenum2.6
esophagus2.6
gallbladder4.9
heart muscle3.7
kidney4.3
liver4
lung3
lymph node6.2
ovary3.5
pancreas2.1
placenta3
prostate3.6
salivary gland2.2
skin3.4
small intestine2.6
spleen5.1
stomach3.5
testis16.4
thyroid gland5.4
urinary bladder3.8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*610740, gene) Trinucleotide repeat-containing gene 6b; TNRC6BOMIM


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