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> Protein (NX_Q9UPX8)
Protein (NX_Q9UPX8)
Protein
Gene SymbolSHANK2 to neXtProt (NX_Q9UPX8)
DescriptionSH3 and multiple ankyrin repeat domains protein 2
Chromosome11
Location11q13.3 (70313961 ~ 70963623) to Ensembl
Sequene Features : Isoforms 4, Variants 196, PTMs 12 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.vocalization behavior
.long term synaptic depression
.long-term synaptic potentiation
  + 6 more...
.ionotropic glutamate receptor binding
.GKAP/Homer scaffold activity
.ciliary membrane
.postsynaptic membrane
.dendritic spine
  + 12 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 196 12
2014-09-19protein level
4 127 12
2014-05-27protein level
4 127 12
2014-02-25protein level
4 126 12
2013-12-09protein level
4 116 12
2013-11-01protein level
4 107 12
2013-09-12protein level
4 107 13
2013-08-17protein level
4 107 13
2013-07-15protein level
4 73 13
2013-06-11protein level
4 73 13
2013-02-12protein level
4 31 24
2012-12-20protein level
4 34 24
2012-10-30protein level
4 34 24
2012-10-07protein level
4 34 8
2012-08-24protein level
4 19 8
2012-07-28protein level
4 19 8
2012-06-08protein level
4 0 8
2012-05-07protein level
4 0 8
2012-04-10protein level
4 0 8
2012-01-13protein level
4 0 8
2011-12-20protein level
4 0 8
2011-11-11protein level
4 0 8
2011-08-23protein level
4 0 8
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9UPX8-1
1 66 1 158723.0877
NX_Q9UPX8-2
1 14 0 30544.7359
NX_Q9UPX8-3
17 66 3 201135.1345
NX_Q9UPX8-4
0 56 0 134846.608
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1570571,EBI-389883 NCK1  
  .negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.negative regulation of PERK-mediated unfolded protein response
  + 23 more...
.eukaryotic initiation factor eIF2 binding
.receptor tyrosine kinase binding
.protein binding, bridging
  + 5 more...
.vesicle membrane
.cell-cell junction
.plasma membrane
  + 6 more...
2 EBI-1570571,EBI-79387 PLCG1  
  .cellular response to epidermal growth factor stimulus
.positive regulation of release of sequestered calcium ion into cytosol
.leukocyte migration
  + 24 more...
.protein kinase binding
.calcium ion binding
.neurotrophin TRKA receptor binding
  + 3 more...
.cell projection
.lamellipodium
.COP9 signalosome
  + 5 more...
3 EBI-1570571,EBI-79464 PIK3R1  
  .positive regulation of endoplasmic reticulum unfolded protein response
.positive regulation of establishment of protein localization to plasma membrane
.growth hormone receptor signaling pathway
  + 41 more...
.1-phosphatidylinositol-3-kinase regulator activity
.insulin receptor substrate binding
.insulin binding
  + 9 more...
.membrane
.phosphatidylinositol 3-kinase complex, class IA
.phosphatidylinositol 3-kinase complex
  + 5 more...
4 EBI-1570571,EBI-886 CRK  
  .ephrin receptor signaling pathway
.neurotrophin TRK receptor signaling pathway
.vascular endothelial growth factor receptor signaling pathway
  + 9 more...
.ephrin receptor binding
.SH2 domain binding
.extracellular exosome
.actin cytoskeleton
.plasma membrane
  + 3 more...
5 EBI-1570571,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bone27
brain30
connective tissue13
ear124
embryonic tissue9
eye38
intestine8
kidney37
larynx42
liver9
lung2
mammary gland39
muscle28
ovary19
pancreas4
placenta17
prostate10
skin4
spleen18
testis4
trachea57
uterus25
Health State
TissuesTPM*
normal26
breast (mammary gland) tumor42
chondrosarcoma24
colorectal tumor8
germ cell tumor3
glioma9
head and neck tumor7
kidney tumor14
liver tumor10
ovarian tumor26
prostate cancer9
uterine tumor55
Developmental Stage
TissuesTPM*
adult17
embryoid body14
blastocyst16
fetus19
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue1.6
adrenal gland1.2
appendix1.4
cerebral cortex12.5
colon6.7
duodenum5.2
esophagus14.8
gallbladder5.5
kidney19.8
liver7.5
lung15.6
pancreas17.7
placenta11.2
prostate11.8
salivary gland22.1
small intestine3.6
spleen1.6
stomach11.2
testis1.9
thyroid gland34.1
urinary bladder8.2
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603290, gene) Sh3 and multiple ankyrin repeat domains 2; SHANK2OMIM
2(#613436, phenotype) Autism, susceptibility to, 17; AUTS17OMIM


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