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> Protein (NX_Q9UPY8)
Protein (NX_Q9UPY8)
Protein
Gene SymbolMAPRE3 to neXtProt (NX_Q9UPY8)
DescriptionMicrotubule-associated protein RP/EB family member 3
Chromosome2
Location2p23.3 (27193480 ~ 27250064) to Ensembl
Sequene Features : Isoforms 2, Variants 27, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of microtubule plus-end binding
.cell division
.positive regulation of transcription, DNA-templated
  + 2 more...
.microtubule binding .perinuclear region of cytoplasm
.microtubule plus-end
.midbody
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 27 4
2014-09-19protein level
2 24 4
2014-05-27protein level
2 24 5
2014-02-25protein level
2 24 5
2013-12-09protein level
2 21 5
2013-11-01protein level
2 21 3
2013-09-12protein level
2 21 4
2013-08-17protein level
2 21 4
2013-07-15protein level
2 7 4
2013-06-11protein level
2 7 4
2013-02-12protein level
2 4 2
2012-12-20protein level
2 6 2
2012-10-30protein level
2 6 2
2012-10-07protein level
2 6 1
2012-08-24protein level
2 5 1
2012-07-28protein level
2 5 1
2012-06-08protein level
2 10 1
2012-05-07protein level
2 7 1
2012-04-10protein level
2 7 1
2012-01-13protein level
2 7 1
2011-12-20protein level
2 7 1
2011-11-11protein level
2 7 1
2011-08-23protein level
2 7 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9UPY8-1
2 9 2 31961.8739
NX_Q9UPY8-2
1 9 2 30360.985
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-726739,EBI-727004 SDCBP  
  .positive regulation of extracellular exosome assembly
.positive regulation of exosomal secretion
.ephrin receptor signaling pathway
  + 9 more...
.protein N-terminus binding
.protein heterodimerization activity
.syndecan binding
  + 4 more...
.blood microparticle
.extracellular exosome
.melanosome
  + 12 more...
2 EBI-726739,EBI-398610 EIF4E2  
  .cytokine-mediated signaling pathway
.negative regulation of translation
.in utero embryonic development
.poly(A) RNA binding
.ubiquitin protein ligase binding
.translation factor activity, RNA binding
  + 2 more...
.mRNA cap binding complex
.cytosol
3 EBI-726739,EBI-1053045 APC2  
  .negative regulation of canonical Wnt signaling pathway
.negative regulation of catenin import into nucleus
.Wnt signaling pathway
.beta-catenin binding .perinuclear region of cytoplasm
.lamellipodium membrane
.catenin complex
  + 6 more...
4 EBI-726739,EBI-852823 JUN  
  .positive regulation of DNA-templated transcription, initiation
.negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.cellular response to calcium ion
  + 60 more...
.R-SMAD binding
.poly(A) RNA binding
.transcription regulatory region DNA binding
  + 15 more...
.transcriptional repressor complex
.cytosol
.nuclear euchromatin
  + 4 more...
5 EBI-726739,EBI-372273 PSMB1  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 23 more...
.threonine-type endopeptidase activity
.endopeptidase activity
.extracellular exosome
.proteasome core complex
.cytosol
  + 4 more...
6 EBI-726739,EBI-359352 PSMA1  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 23 more...
.threonine-type endopeptidase activity
.endopeptidase activity
.RNA binding
.extracellular exosome
.proteasome core complex, alpha-subunit complex
.polysome
  + 7 more...
7 EBI-726739,EBI-739696 LMO2  
  .cellular response to thyroid hormone stimulus
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of erythrocyte differentiation
  + 3 more...
.E-box binding
.cofactor binding
.bHLH transcription factor binding
  + 7 more...
.transcription factor complex
.nucleus
8 EBI-726739,EBI-2349743 TROAP  
  .cell adhesion .N/A .cytoplasm
9 EBI-726739,EBI-1004115 MAPRE1  
  .positive regulation of microtubule plus-end binding
.cell division
.protein localization to microtubule
  + 7 more...
.microtubule plus-end binding
.poly(A) RNA binding
.protein C-terminus binding
.microtubule plus-end
.cell projection membrane
.cortical microtubule cytoskeleton
  + 6 more...
10 EBI-726739,EBI-741261 APPL2  
  .cell proliferation
.signal transduction
.cell cycle
.N/A .extracellular exosome
.early endosome membrane
.endosome membrane
  + 2 more...
11 EBI-726739,EBI-2932492 TXN2  
  .oxidation-reduction process
.response to axon injury
.cell redox homeostasis
  + 12 more...
.peptide-methionine (R)-S-oxide reductase activity
.oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
.protein disulfide oxidoreductase activity
.peptide-methionine (S)-S-oxide reductase activity
.neuronal cell body
.dendrite
.mitochondrial matrix
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites50
bone41
brain103
connective tissue13
embryonic tissue14
eye114
heart11
intestine73
kidney61
larynx42
liver4
lung53
mammary gland19
muscle18
ovary59
pancreas234
parathyroid145
placenta77
prostate31
skin4
stomach10
testis50
thymus12
trachea77
uterus25
Health State
TissuesTPM*
normal71
breast (mammary gland) tumor10
chondrosarcoma48
colorectal tumor8
gastrointestinal tumor25
germ cell tumor18
glioma205
head and neck tumor7
kidney tumor14
liver tumor10
lung tumor38
non-neoplasia41
ovarian tumor78
pancreatic tumor28
primitive neuroectodermal tumor of the CNS15
prostate cancer19
retinoblastoma21
uterine tumor11
Developmental Stage
TissuesTPM*
adult54
embryoid body14
blastocyst32
fetus23
infant85
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue21.1
adrenal gland24.8
appendix8.8
bone marrow1.1
cerebral cortex98.7
colon15
duodenum8.1
esophagus12
gallbladder17.9
heart muscle28
kidney15.6
liver12.8
lung16.9
lymph node7.3
ovary37
pancreas7.8
placenta17.8
prostate21.3
salivary gland10.7
skin27
small intestine6.3
spleen10.2
stomach17.4
testis49.1
thyroid gland17.9
urinary bladder11.4
Tissues
TissuesExpression level
adrenal glandLow
appendixLow
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineLow
colonHigh
endometrium 1Low
endometrium 2Medium
epididymisLow
fallopian tubeHigh
gallbladderLow
heart muscleLow
hippocampusHigh
lateral ventricleHigh
liverLow
lungLow
nasopharynxHigh
ovaryLow
pancreasMedium
parathyroid glandMedium
placentaLow
prostateLow
rectumLow
seminal vesicleLow
skeletal muscleLow
soft tissue 1Low
soft tissue 2Medium
stomach 1Low
stomach 2Low
testisMedium
thyroid glandLow
tonsilMedium
urinary bladderLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*605788, gene) Microtubule-associated protein, rp/eb family, member 3; MAPRE3OMIM


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